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Refractive and diffractive neutron optics with reduced chromatic aberration
Thermal neutron beams are an indispensable tool in physics research. The spatial and the temporal resolution attainable in experiments are dependent on the flux and collimation of the neutron beam which remain relatively poor, even for modern neutron sources. These difficulties may be mitigated by the use of optics for focusing and imaging. Refractive and diffractive optical elements, e.g. compoun
a multicentre, phase ii study of cp-4055 in combination with sorafenib in patients with metastatic malignant melanoma
Rheochaos and flow instability phenomena in a nonionic lamellar phase
In this study we report on instability phenomena in a solution where shear induces multilamellar vesicles (MLVs) from a lamellar phase. A shear-thickening regime has been observed for hexadecyl tetraethylene glycol ether (C16E4) dissolved in D2O at 40 degrees C. In this regime, unstable temporal viscosity behavior, i.e. periodic oscillations, has been observed at 2, 5 and 10 s(-1). Moreover at a s
The Gold Standard Programme: smoking cessation interventions for disadvantaged smokers are effective in a real-life setting
Objectives To evaluate the real-life effect of an evidence-based Gold Standard Programme (GSP) for smoking cessation interventions in disadvantaged patients and to identify modifiable factors that consistently produce the highest abstinence rates. Design Observational prospective cohort study. Setting GSPs in pharmacies, hospitals and communities in Denmark, reporting to the national Smoking Cessa
Study of b-quark mass effects in multijet topologies with the DELPHI detector at LEP
The effect of the heavy b-quarkmass on the two, three and four-jet rates is studied using LEP data collected by the DELPHI experiment at the Z peak in 1994 and 1995. The rates of b-quark jets and light quark jets (l = uds) in events with n = 2, 3, and 4 jets, together with the ratio of two and four-jet rates of b-quarks with respect to light-quarks, R-n(bl), have been measured with a double-tag te
Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer
Background: Although omic-based discovery approaches can provide powerful tools for biomarker identification, several reservations have been raised regarding the clinical applicability of gene expression studies, such as their prohibitive cost. However, the limited availability of antibodies is a key barrier to the development of a lower cost alternative, namely a discrete collection of immunohist
Phosphine addition to the sigma,pi-thienyl complex [Fe-2(CO)(6)(mu-Th)(mu-PTh2)] (Th = C4H3S): Carbonyl substitution and migratory carbonyl insertion to give the thienyl-acyl complexes [Fe-2(CO)(4)(diphosphine)(mu-O=C-Th)(mu-PTh2)]
The reactivity of the sigma,pi-thienyl complex [Fe-2(CO)(6)(mu-Th)(mu-PTh2)] (1) towards a range of phosphines has been studied. With PR3 (R = Ph, Th) carbonyl substitution affords [Fe-2(CO)(5)(PR3)(mu-Th)(mu-PTh2)] (2ab) as the major product, with smaller amounts of the thienylacyl complexes [Fe-2(CO)(5)(PR3)(mu-O=C-Th)(mu-PTh2)] (3ab) resulting from a migratory carbonyl insertion into the thieny
HLA-DRB1*04/*13 alleles are associated with vascular disease and antiphospholipid antibodies in systemic lupus erythematosus
Background and objectives Vascular disease is common in systemic lupus erythematosus (SLE) and patients with antiphospholipid antibodies (aPL) are at high risk to develop arterial and venous thrombosis. Since HLA class II genotypes have been linked to the presence of pro-thrombotic aPL, we investigated the relationship between HLA-DRB1 alleles, aPL and vascular events in SLE patients. Methods 665
Situations of water reuse in China
Water reuse is a cost-effective solution that is carried out in many water-shortage countries on different levels. China, which is the most populous country in the world, is facing a serious water crisis, with great demand and feasibility to use reclaimed water to deal with freshwater shortage and pollution. Although much progress has been made, challenges and problems still exist, which hinder th
Preservation effects on stable isotope ratios and consequences for the reconstruction of energetic pathways
Stable isotope analysis provides a powerful tool for describing the energetic pathways in a variety of ecosystems. However, isotope ratios of animal tissues can be altered by preservation methods, potentially leading to biased estimates of energy pathways when they are not taken into account. Here, we investigated the direct preservation effects of formalin, ethanol, NaCl, and drying on the delta
A Model To Predict Cardiovascular Events In Patients With Newly Diagnosed Wegener'S Granulmoatosis And Microscopic Polyangiitis
Furniture Design beyond Usability. Changes for People in the Third Age when Moving to a New Home.
User-centred design approaches within the field of furniture design for old people involves an act of embracing and balancing various end-user needs and assessing their relative importance for the product experience. It is often assumed that older people’s physiological needs dominate their other needs. In the present study, three focus group interviews were carried out with the exploratory purpos
The Observation Scale for Autism (OSA): A New Screeening Method to Detect Autism Spectrum Disorder before Age Three Years
Final report: A participatory method for need based capacity development projects and programmes
The three-year research project funded by MSB applies design science, in combination with traditional scientific investigation, to develop a method to guide the planning phase of capacity development projects for disaster risk reduction and climate change adaptation. The method facilitates local participation and ownership as it builds on the strengths of the Logical Framework Approach (LFA), whil
Nanotubes and bilayers in a model peptide system
The trifluoroacetate (tfa) salt of the peptide (ala)(6)lys self-assembles in water into very long, hollow nanotubes with a radius R = 26 nm, above a critical aggregation concentration (volume fraction), phi(cac) = 0.10. The peptides carry a net positive charge that ensures colloidal stability of the self-assembly structures through a long-range electrostatic repulsion. There is only a weak tempera
Red fox and tick-borne encephalitis (TBE) in humans: Can predators influence public health?
Analysing datasets from hunting statistics and human cases of tick-borne encephalitis (TBE), we found a positive correlation between the number of human TBE cases and the number of red fox (Vulpes vulpes). Time lags were also present, indicating that high numbers of red fox in 1 y translated into high numbers of human TBE cases the following y. Results for smaller predators were mixed and inconsis
A NEW APPROACH TO CRACK CONTROL FOR REINFORCED CONCRETE - An investigation of crack widhts close to the reinforcement and the correlation to service life
One of the most important factors governing durability of concrete structures is reinforcement corrosion, and to prevent degradation associated with it, it is desirable to use large concrete covers. However, if the concrete cover is increased, the majority of design methods will predict that the crack widths at the concrete surface increase significantly. This can be contradictory, since the same
Introduction to the BIOMED 2014 feature issue
The guest editors introduce a feature issue containing papers based on research presented at the BIOMED 2014 conference, held in Miami, FL, April 26-30, 2014. (C) 2014 Optical Society of America
A new murine IgG1 anti-Tn monoclonal antibody with in vivo anti tumour activity.
The Tn antigen (GalNAc alpha-O-Ser/Thr) is heterogeneously synthesised by a variety of tumours and contains an epitope defined by lectins and antibodies as a cluster of alpha GalNAc carbohydrates synthesised within a peptide sequence, which is rich in serine and/or threonine. The Tn antigen has been utilized as a target in vaccine experiments and also used as a biomarker for prognosis of different