Methylation of the cytosine bases in CpG dinucleotides of DNA is important in many cellular functions including gene regulation, chromosome inactivation, as well as in cancer and other diseases. In this report we investigate the structural effects of methylation of cytosines in CpG sites. Hereditary diseases are frequently caused by mutations in CpG dinucleotides. Aqueous solution molecular dynami

Abstract is not available.

Syftet med denna avhandling var att undersöka omsorg som begrepp och handling och att se hur omsorg kan yttra sig under olika villkor. Avhandling innehåller en översikt över icke-feministiska och feministiska teorier och filosofier om omsorg samt en empirisk undersökning av uppfattningar om omsorg och omsorgshandlingar i fyra yrkesgrupper: fastighetsansvariga, kvarterspoliser, distriktssjukskötersThe aim of this study was to investigate care as concept and action and to see how care can be expressed in different conditions. The dissertation contains a survey of non-feminist and feminist theories of care and an empirical study of views of care and caring acts in four professional groups: janitors, neighbourhood police, district nurses, and home-helpers. The study, which is based on intervie

We have identified a novel protein, Leprecan-like 1 (LEPREL1), with profound similarity to the Leprecan family of proteoglycans. The genomic organization of the Leprecan gene family was found to be highly conserved. Expression analysis shows that LEPREL1 is expressed in most tissues as a 3.4 kb transcript encoding an 80 kDa protein. A LEPREL1 specific antibody stains many cell types including adip

Background. Echocardiographically determined left atrioventricular plane displacement (AVPD) is strongly related to prognosis in patients with chronic heart failure and in postmyocardial infarction patients. We aimed at exploring whether AVPD, unlike ejection fraction, is related to mortality in patients with stable coronary artery disease (CAD). Methods and results. Atrioventricular plane displac

A study of attitudes toward the physical environment in Malmö, towards particular environmental issues and on the willingness and ability of the citizens to perform environmental actions.

Abstract In the given report, scientific results gathered at the Alfred- Wegener- Institut für Polar- und Meeresforschung (AWI) within an ScD contract are summarized. The AWI is the German large scale research facility for polar- and marine research. In January 1992 +he new research de- partment at Potsdam has been established with the section Physics und Chemistry of the Atmosphere. 1t coordinate

The high-resolution Fourier transform infrared spectrum of trans-glyoxal in the gas phase has been recorded in the spectral regions 700-900 cm(-1), 1200-1400 cm(-1), and 1600-1800 cm(-1) with a resolution ranging from 0.0020 to 0.0025 cm(-1). The spectrum displays extensive rotational structures which are assigned to the three fundamental bands upsilon(6) (A(u), 801.5 cm(-1)), upsilon(10) (B-u, 17

A new criterion is applied for characterization of the kinetic design of enzymes that should be favoured by a selective pressure in the direction of increased metabolic reaction flux. According to this criterion, the selectively favoured state of a metabolic sequence of enzyme reactions conforming to Michaelis-Menten kinetics is identical with the uniform one which is known to optimize reaction fl

We study Hamming versions of two classical clustering problems. The Hamming radius p-clustering problem (HRC) for a set S of k binary strings, each of length n, is to find p binary strings of length n that minimize the maximum Hamming distance between a string in S and the closest of the p strings; this minimum value is termed the p-radius of S and is denoted by varrho. The related Hamming diamete

In our previous paper [M.A. Borowiak, M.H. Jamroz, R. Larsson, J. Mol. Catal. A: Chem., 139 (1999) 97], an impulse-oscillation model (IOM) was used for a time description of catalytic acts in the reactions of catalytic decomposition of formic acid on oxide catalysts for unimolecular mechanism. In this paper: the bimolecular mechanism were modelled for the same reactions. The results of IOM calcula

The purpose of this study was to investigate the prognostic implications of BCL6 rearrangement in a uniformly treated population of patients with diffuse large B-cell lymphoma (DLBCL) and to characterise the relationship between BCL6 rearrangement and prognostic factors. A total of 269 patients with DLBCL entered a randomised trial comparing the chemotherapy regimen CHOP (cyclophosphamide, doxorub

A method for direct measurement of hexahydrophthalic anhydride (HHPA) in workplace air by use of a Fourier transform infrared (FTIR) spectrometer was developed. Two visits were made to a plant manufacturing capacitors where HHPA was used. On the first visit a calibration method was developed according to what was expected to give the best calibration. This was performed by collection of 82 FTIR sp

The role of the B800 in energy and electron transfer in LH2 complexes has been studied using femtosecond time-resolved transient absorption spectroscopy. The B800 site was perturbed by application of lithium dodecyl sulfate (LDS), and comparison of treated and untreated LH2 complexes from Rhodobacter sphaeroides incorporating carotenoids neurosporene, spheroidene, and spheroidenone was used to exp