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Human single-strand-selective monofunctional uracil DNA glycosylase 1 (hSMUG1) removes uracil, 5-hydroxymethyluracil (5hmU) and 5-fluorouracil (5FU) from DNA, thereby initiating the base excision repair (BER) process. hSMUG1 is important for maintaining genomic integrity and plays a significant role in cancer biology. Here, we present the structures of hSMUG1, including complexes with products (ur
Background: Frailty represents a state of compromised ability to cope with environmental stressors and is associated with negative health-related outcomes in older adults. The study objective is to investigate the prevalence and whether frailty associates with negative health-related outcomes in middle-aged adults. Methods: Data were sourced from three 2-year cycles of NHANES surveys and combined
Background Increased airflow is reported as helpful in reducing the sensation of breathlessness. This systematic review aimed to assess the effectiveness of airflow on breathlessness (primary outcome, measured using a validated tool at rest or during exercise) and health-related quality of life (secondary outcome) in people with serious respiratory illness. Methods We searched Ovid MEDLINE, Embase
Accurate mapping of earthquake-damaged buildings is essential for rapid post-disaster assessment and urban recovery planning. Very high-resolution (VHR) satellite imagery enables large-scale geospatial damage detection; however, conventional convolutional neural networks (CNNs) often struggle to model complex spatial dependencies and nonlinear damage patterns efficiently. To address these limitati
BackgroundRight ventricular (RV) failure is a key determinant of outcome in precapillary pulmonary hypertension (PHprecap). Contemporary four-strata risk assessment incorporates functional capacity and NT-proBNP, yet the relationship between these and RV function remains unclear. We therefore examined these associations in PHprecap.Methods and resultsPatients with PHprecap (n=49; 69% women, median
Aims: This study describes the Norwegian Sports Membership Database (NSMD), assesses its coverage, and develops definitions of active sports memberships. Methods: We validated the coverage of the NSMD, a database capturing individual-level sports memberships among people aged 10–70 years between 2015 and 2024. We compared yearly membership counts in the NSMD with figures from official reports from
BackgroundPost-transplant diabetes mellitus (PTDM) is common after orthotopic heart transplantation (OHT), but its long-term impact on myocardial function is unclear. We aimed to evaluate the effects of PTDM on left ventricular (LV) systolic function.MethodsWe prospectively studied 102 OHT recipients with echocardiographic follow-up at 1-, 3-, and 5-year post-transplant. Patients were classified a
Background: Poor self-reported sleep quality is associated with cognitive impairment. Alzheimer’s disease (AD) patients present sleep disruptions decades before they start to decline clinically. Similarly, amyloid-β (Aβ) starts accumulating during the preclinical phase of the disease. This study investigated associations between self-reported sleep quality and Aβ burden longitudinally in clinicall
NaOH and NaCl vapor are key alkali compounds released during the thermal conversion of high-alkali coal and municipal solid waste, and their accurate measurement is crucial for understanding the mechanisms of ash deposition, slagging, and other related issues. However, in-situ and species-specific measurement techniques with high sensitivity for NaOH and NaCl molecules in hash combustion environme
Background and Purpose Post-mastectomy radiotherapy (PMRT) improves both the locoregional control and survival in advanced breast cancer. While the use of bolus can enhance skin dose, many oncologists prefer not to use it because of the dramatic increase in skin toxicity. The optimal technique to ensure adequate skin dose is unknown, and this study compares the superficial dose for three technique
Road traffic injuries remain a major public health concern in Tanzania. The World Health Organisation (WHO) estimated that in 2021, more than 10,000 people were killed in road traffic accidents in Tanzania, with pedestrians accounting for approximately 26% of all fatalities. This underscores the urgent need for thorough, context-specific analyses of the risk factors contributing to fatal pedestria
Image compression is crucial for storing remote sensing data in space-constrained on-orbit systems. Current methods primarily follow two directions. The first combines wavelet transforms with post-processing, leveraging wavelets' sparse representation for multi-resolution analysis and efficient hardware implementation. The second employs compressed sensing (CS), which shifts complexity to the deco
In this paper, a new framework – RoadRAT - for analyzing the probability of inundation, wave runup, and erosion is applied within the context of risk management for coastal roads. The analysis focus on a case study in south Sweden and consists of risk identification, calculation of probability, and discussion of consequences and mitigation methods. The results show that future risks are highly dep
PURPOSE: To demonstrate a self-derived, dynamic field map (∆B0) estimation and correction method for improved CEST measurements without additional scans, especially in the presence of subject motion. METHODS: Dynamic ∆B0 maps were derived directly from the CEST images acquired with rosette readout trajectories by segmenting the rosette k-space data. The rosette ∆B0 mapping accuracy was validated a
Background: Developing new diagnostic imaging methods that provide detailed visualization of the histoanatomy of tissues and organs requires precise histomorphometric evaluation. With a particular focus on bowel, this study aimed to develop and validate a computer program for reliable and efficient assessment of bowel wall histomorphometry. Methods: A MATLAB-based computer program was developed in
Objective: The primary aim of this study was to develop and internally validate ultrasound-based radiomics models to discriminate between all types of benign and malignant adnexal masses. The secondary aim was to compare the performance of the radiomics models with that of the Assessment of Different NEoplasias in the adneXa (ADNEX) model. Methods: This was a retrospective, observational, single-c
AbstractIntroductionWork environments are rapidly changing in Europe, with climate change, the transition to the circular economy, and expansion of work in green jobs among key factors. Research and interventions are urgently needed to promote worker health and well-being. The European Union (EU) INTERCAMBIO project is the first large-scale initiative to systematically assess mental and physical h
Background: Hypertension and smoking are well-known risk factors for aortic dissection (AD), but it is unclear whether other lifestyle factors influence the risk. The aim of this study was to investigate the association between diet quality, physical activity, and risk of AD. Methods: The study included 28,094 participants from the Malmö Diet and Cancer Study, recruited between 1991 and 1996 and f
Background: Local networks have been recognized for their potential to govern collaborative action toward a low-carbon future in urban areas, yet there is a need to learn more about the strengths and weaknesses of such governance structures. In this paper we assess the Local Roadmap for a Climate Neutral Building & Construction Industry in Malmö 2030 (LFM30) network which was initiated in 2018
This article examines Karl Ove Knausgård’s novel Morgenstjernen (2020, The Morning Star) as a series of interconnected pre-apocalyptic narratives. Using the framework of econarratology alongside the concept of ‘hyperobjects’ and terminology that points to the interconnectedness of all systems, I explore how the narratives we are able to tell in a changing world affect both ourselves and our relati
