The haematopoietic stem cell (HSC) resides within a specific environment enabling it to retain its self-renewal capacity or quiescent state. It is proposed that the HSC niche is hypoxic, a milieu within which the HSC is protected from intrinsic and extrinsic stimuli. We have investigated the haematopoietic phenotype of an HSC in a mouse model where hypoxia-regulated Vegfa expression is abrogated.

This study investigates the genetic structure of an eukaryotic microorganism, the toxic dinoflagellate Alexandrium ostenfeldii, from the Baltic Sea, a geologically young and ecologically marginal brackish water estuary which is predicted to support evolution of distinct, genetically impoverished lineages of marine macroorganisms. Analyses of the internal transcribed spacer (ITS) sequences and Ampl

We have studied the effect of different light gradient regimes on host-plant selection of the carrot psyllid, Trioza apicalis Forster. In both a strong and a weak light gradient, carrot psyllids preferred a carrot leaf placed in higher light intensity. When the choice was between the host (carrot Daucus carota L.) and a non-host (barley Hordeum vulgare L.) virgin adults settled significantly more

Background: Physical benefits are suggested for women and their babies when women adopt an upright position of their choice at birth. Available care options during labour influence women's impressions of what intrapartum care is. This indicates that choice of birth positions may be determined more by midwives than by women's preferences. Question: The aims of this study were to investigate factors

At low temperature, cell membrane functionality depends on adjustments of membrane phospholipid fatty acid (PLFA) composition. We here test the hypothesis that previous exposure to copper (Cu) may deteriorate tolerance to freezing temperatures because of Cu-induced changes of PLFA composition of cell membranes in the freeze-tolerant earthworm Dendrobaena octaedra. Cu levels and freezing temperatur

OBJECTIVE: The aim was to elucidate the role of genetic variants on symptoms of the eyes and airways, headache and nausea, as well as on immunologic markers, among vulcanization workers in the contemporary Swedish rubber industry. Polymorphisms in genes, which are involved in the defense against reactive oxygen species and metabolism of toxic substances present in the vulcanization fumes, were ana

This article builds on an action research process involving Ugandan smallholder farmers in collaborative experimentation on the use of human urine as a crop fertilizer. The aim is to explore farmers' perceptions and evaluation of the practice as a potential and partial solution to soil productivity problems. Findings show that urine fertilization is valued as a low-cost and low-risk practice contr

An efficient lighting control systems (LCS) should take advantage of the natural light available, but this presents some technical challenges as well as user related issues. So far, the assessment of lighting energy consumption of LCS has been based on technical features rather than the occupants’ acceptance. This article presents the results of a monitoring study providing some recommendations ba

A molecular level understanding of the structural reorganization accompanying interfacial electron transfer is important for rational design of solar cells. Here we have applied XTA (X-ray transient absorption) spectroscopy to study transient structures in a heterogeneous interfacial system mimicking the charge separation process in dye-sensitized solar cell (DSSC) with Ru(dcbpy)(2)(NCS)(2) (RuN3)

OBJECTIVE-The incretin hormone GIP (glucose-dependent insulinotropic polypeptide) promotes pancreatic beta-cell function by potentiating insulin secretion and beta-cell proliferation. Recently, a combined analysis of several genome-wide association studies (Meta-analysis of Glucose and Insulin-Related Traits Consortium [MAGIC]) showed association to postprandial insulin at the GIP receptor (GIPR)

In a previously published study, vildagliptin showed a reduced risk of hypoglycemia versus glimepiride as add-on therapy to metformin at similar efficacy. Glimepiride was titrated from a starting dose of 2 mg/day to a maximum dose of 6 mg/day. It is usually assumed that the increased hypoglycemia with glimepiride was driven by the 6 mg/day dose; it was therefore of interest to assess whether the r

The exact incidence and prevalence of Budd-Chiari syndrome (BCS) is unknown in the general population. Published reports differ in terms of the clinical characteristics, effects of therapy and survival. To investigate the epidemiology, clinical presentation and survival in patients with BCS. Retrospective multicentre study in Sweden reviewing the medical records of all patients with BCS 1986-2003,

Popular Abstract in Swedish Våra celler är täckta av kolhydrater (socker) som är kopplade till proteiner och lipider på cellens yta. Olika celler presenterar olika socker, och en och samma cell kan dessutom ändra sitt sockeruttryck beroende på hur den mår och vad den vill utföra, till exempel dela sig eller dö, en effekt man ofta ser i cancer. På så sätt fungerar sockerstrukturerna som en kod som There is an intensive interest in characterising the structure and function of galectins, which is not surprising given their many important cellular functions and strong implications in human disease. Understanding the mechanisms involved in galectin functions will help to find selective and novel strategies for disease treatment and diagnosis. A key to this lies in their carbohydrate binding spe

To evaluate the impact of low birth weight as a risk factor for retinopathy of prematurity (ROP) that will require treatment in correlation with gestational age at birth (GA).

In recent years, it has become increasingly important to get as much as possible information on clinical efficacy already in the early phases of drug development. For proof of concept (POC) studies testing novel anti-inflammatory drugs in asthma, there are several validated exacerbation models, inducing various aspects of the airway inflammation and airway responsiveness. The choice of the appropr

This paper addresses the need of continued education of process industry practitioners such as operators and instrumentation engineers. The process industry regulatory control tuning situation of today is reviewed. Areas of potential improvement are identified. A course, aimed at fulfilling these needs is presented. Especially, useful laboratory experiments are outlined. The suggested course was g