Apelin, a ligand of the APJ receptor, is overexpressed in several human cancers and plays an important role in tumor angiogenesis and growth in various experimental systems. We investigated the role of apelin signaling in the malignant behavior of cutaneous melanoma. Murine B16 and human A375 melanoma cell lines were stably transfected with apelin encoding or control vectors. Apelin overexpression

Objectives: The main goal of the COVIDENZA trial is to evaluate if inhibition of testosterone signalling by enzalutamide can improve the outcome of patients hospitalised for COVID-19. The hypothesis is based on the observation that the majority of patients in need of intensive care are male, and the connection between androgen receptor signalling and expression of TMPRSS2, an enzyme important for

The surface electron density significantly affects the photocatalytic efficiency, especially the photocatalytic CO2 reduction reaction, which involves multi-electron participation in the conversion process. Herein, we propose a conceptually different mechanism for surface electron density modulation based on the model of Au anchored CdS. We firstly manipulate the direction of electron transfer by

Decreased glomerular filtration rate (GFR) is linked to poor survival. The predictive value of creatinine estimated GFR (eGFR) and cystatin C eGFR in critically ill patients may differ substantially, but has been less studied. This study compares long-term mortality risk prediction by eGFR using a creatinine equation (CKD-EPI), a cystatin C equation (CAPA) and a combined creatinine/cystatin C equa

Compared to petroleum diesel, renewable diesel fuels and exhaust aftertreatment systems can reduce primary exhaust emissions that are hazardous to human health and the environment. Secondary aerosol emissions which form upon atmospheric processing have, however, been less studied. This study aimed to quantify the impacts of replacing petroleum diesel with renewable fuels (hydrotreated vegetable oi

Thalassomedon haningtoni is one of the most completely preserved elasmosaurid plesiosaurians described to date. Unlike most other elasmosaurid fossils, both the holotype and a second referred specimen — which were recovered from the middle Cenomanian Graneros Shale in the mid-western USA — are represented by intact skulls with articulated postcranial skeletons. Thalassomedon haningtoni thus consti

In response to the stringent emission regulations, artificial neural network (ANN) coupled with genetic algorithm (GA) is employed to optimize a novel internal combustion engine strategy named direct dual fuel stratification (DDFS). An enhanced ANN model is introduced to improve the accuracy and stability of predictions. Compared to the conventional computational fluid dynamics (CFD)-GA optimizati

The state of corrosion of three pre-cracked concrete beams was investigated after 25 years of marine exposure (atmospheric, tidal and submerged). The influence of inadequate plastic spacers was found to overrule the possible impact of bending cracks on reinforcement corrosion. Increased chloride ingress was detected in cracked areas, but very little corrosion was observed where cracks reached the

Increased physical activity can have health benefits among inactive individuals. In Sweden, the healthcare system uses physical activity on prescription (PAP) to motivate patients to increase their physical activity level. Mindfulness may further heighten the internal motivation to engage in physical activity. However, previous research has not demonstrated clear evidence of such an association.AI

There is a significant lack of geomagnetic field strength (archaeointensity) measurements for many archaeological time periods in the United Kingdom (UK). This not only makes past geomagnetic secular variation difficult to model but also limits the development of archaeointensity dating. This paper presents the first archaeointensity study on UK Neolithic material. In this study, twenty-five sherd

Concerns over climate change are motivated in large part because of their impact on human society. Assessing the effect of that uncertainty on specific potential impacts is demanding, since it requires a systematic survey over both climate and impacts models. We provide a comprehensive evaluation of uncertainty in projected crop yields for maize, spring and winter wheat, rice, and soybean, using a

Electricité de France (EDF) operates a large fleet of nuclear reactors and is responsible for demonstrating the safety of facilities, including concrete containment buildings (CCB), which are non-replaceable components. The leak-tightness of CCBs is assessed every 10 years during integrated leak-rate tests (IRLT). For double-wall containments, which have no metallic liners, the leak-tightness is s

The way microbes behave in nature can vary widely depending on the spatial characteristics of the habitats they are located in. The spatial structure of the microbial environment can determine whether and to which extent processes such as organic matter degradation, and synergistic or antagonistic microbial processes occur. Investigating how the different spatial characteristics of microhabitats i

Kvalitetsdokument för bröstpatologi

In this paper, effects of four different hole configurations on film cooling performance and particle deposition are investigated numerically on a curved surface. The RNG k-ε turbulence model is used, and the discrete phase model is developed by user-defined functions. The particle deposition on the curved surface is analyzed by calculated results of capture and impact efficiencies. Results show t