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Systematic evaluation of non-animal test methods for skin sensitisation safety assessment.

The need for non-animal data to assess skin sensitisation properties of substances, especially cosmetics ingredients, has spawned the development of many in vitro methods. As it is widely believed that no single method can provide a solution, the Cosmetics Europe Skin Tolerance Task Force has defined a three-phase framework for the development of a non-animal testing strategy for skin sensitisatio

G Protein-coupled Receptor 30 (GPR30) Forms a Plasma Membrane Complex With Membrane-associated Guanylate Kinases (MAGUKs) and AKAP5 That Constitutively Inhibits cAMP Production.

GPR30, or G protein-coupled estrogen receptor (GPER), is a GPCR reported to bind 17β-estradiol (E2), couple to the G proteins Gs and Gi/o, and mediate non-genomic estrogenic responses. However, controversies exist regarding the receptor pharmacological profile, effector coupling, and subcellular localization. We addressed the role of the type I PSD-95/Discs-large/ZO-1 homology (PDZ) motif at the r

Holocene environmental changes in southern Kamchatka, Far Eastern Russia, inferred from a pollen and testate amoebae peat succession record

High resolution palaeoenvironmental records in Far-Eastern Russia are rare, and the Kamchatka Peninsula is among the least studied areas of the region. This paper describes a record spanning the last ca. 11,000 yr, obtained from a bog in the southern part of Kamchatka. The radiocarbon dated core was analysed for pollen, testate amoebae, charcoal and loss-on-ignition (LOI). The vegetation during th

Experimental testing of load-bearing timber–glass composite shear walls and beams

The paper presents results from the experimental testing of load-bearing timber–glass composite shear walls and beams. Shear wall specimens measuring 1200 × 2400 mm2 manufactured with three adhesives of varying stiffness were tested. Twelve specimens with a single 10 mm thick glass pane and one specimen with an additional insulating glass unit were produced. The testing procedures involved various

European Stroke Organisation (ESO) guidelines for the management of spontaneous intracerebral hemorrhage

BackgroundIntracerebral hemorrhage (ICH) accounted for 9% to 27% of all strokes worldwide in the last decade, with high early case fatality and poor functional outcome. In view of recent randomized controlled trials (RCTs) of the management of ICH, the European Stroke Organisation (ESO) has updated its evidence-based guidelines for the management of ICH. MethodA multidisciplinary writing committee

Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2

Background & Aims: The Glu167Lys (E167K) variant in the transmembrane 6 superfamily member 2 protein (TM6SF2) was recently shown to influence liver fat (LFAT) content. We aimed at studying how this variant influences circulating triacylglycerol (TAG) signatures and whether it influences hepatic or adipose tissue insulin sensitivity. Methods: We genotyped 300 Finnish subjects for the E167K (rs5

A QPTAS for the Base of the Number of Crossing-Free Structures on a Planar Point Set

The number of triangulations of a planar n point set S is known to be c^n, where the base c lies between 2.43 and 30. Similarly, the number of spanning trees on S is known to be d^n, where the base d lies between 6.75 and 141.07. The fastest known algorithm for counting triangulations of S runs in O^∗(2^n) time while that for counting spanning trees runs in O^∗(7.125^n) time. The fastest known arb

Search for the lepton flavor violating decay Z -> e mu in pp collisions at root s=8 TeV with the ATLAS detector

The ATLAS detector at the Large Hadron Collider is used to search for the lepton flavor violating process Z -> e mu in pp collisions using 20.3 fb(-1) of data collected at root s = 8 TeV. An enhancement in the e mu invariant mass spectrum is searched for at the Z-boson mass. The number of Z bosons produced in the data sample is estimated using events of similar topology, Z -> ee and mu mu, signifi

Clinical aspects of using exhaled NO in asthma diagnosis and management

Background Current guidelines recommend tailoring of asthma management according to disease control, which is largely defined by increased symptoms and deterioration in lung function. These features do not reflect the severity nor the type of the asthmatic airway inflammation. Fractional exhaled nitric oxide (FENO) is a simple, non-invasive and cost-effective online test applicable in both adults

Evolution of anodic stress corrosion cracking in a coated material

In the present paper, we investigate the influence of corrosion driving forces and interfacial toughness for a coated material subjected to mechanical loading. If the protective coating is cracked, the substrate material may become exposed to a corrosive media. For a stress corrosion sensitive substrate material, this may lead to detrimental crack growth. A crack is assumed to grow by anodic disso

Numerical methods in vehicle system dynamics: state of the art and current developments

Robust and efficient numerical methods are an essential prerequisite for the computer based dynamical analysis of engineering systems. In vehicle system dynamics, the methods and software tools from multibody system dynamics provide the integration platform for the analysis, simulation and optimization of the complex dynamical behaviour of vehicles and vehicle components and their interaction with h

Bidirectional plasticity of purkinje cells matches temporal features of learning

Many forms of learning require temporally ordered stimuli. In Pavlovian eyeblink conditioning, a conditioned stimulus (CS) must precede the unconditioned stimulus (US) by at least about 100 ms for learning to occur. Conditioned responses are learned and generated by the cerebellum. Recordings from the cerebellar cortex during conditioning have revealed CS-triggered pauses in the firing of Purkinje

Antennas and Propagation for In-Mouth Tongue Controlled Devices in Wireless Body Area Networks

Tetraplegic patients have to depend upon someone else for moving the wheelchair or typing on a computer. One of the ways to make them independent is by using tongue-controlled in-mouth wireless devices. This letter presents antennas and propagation for such devices in 2.45 GHz ISM band. A monopole and a loop antenna suitable in size and performance is presented for such devices. The propagation li

Rating curve uncertainty and change detection in discharge time series : Case study with 44-year historic data from the Nyangores River, Kenya

The intersection of the developing topic of rating curve and discharge series uncertainty with the topic of hydrological change detection (e.g., in response to land cover or climatic change) has not yet been well studied. The work herein explores this intersection, with consideration of a long-term discharge response (1964-2007) for a ~650-km2 headwater basin of the Mara River in west Kenya, start

Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk.

In experimental studies, enkephalins (ENKs) and related opioids have been implicated as negative regulators of breast cancer development by enhancing immune-mediated tumoral defense as well as directly inhibiting cancer cells. We hypothesized that plasma levels of ENKs are predictive of the long-term breast cancer risk. Therefore, our objective was to measure pro-ENK A, a surrogate for mature ENK,

Influence of Pulsed Electric Field Protocols on the Reversible Permeabilization of Rucola Leaves

Reversible electropermeabilization of plant tissues with heterogeneous structure represents a technological challenge as the response of the different structures within the same specimen to the application of electric field may differ due to different cell sizes, extracellular space configurations, and electrical properties. The influence of five different pulsed electric field protocols with diff

Activity-independent release of the amyloid β-peptide from rat brain nerve terminals.

Synaptic degeneration is one of the earliest hallmarks of Alzheimer disease. The molecular mechanism underlying this degeneration is not fully elucidated but one key player appears to be the synaptotoxic amyloid β-peptide (Aβ). The exact localization of the production of Aβ and the mechanisms whereby Aβ is released remain elusive. We have earlier shown that Aβ can be produced in crude synaptic ves

Managing the sacred? Perspectives on teaching excellence and learning outcomes from an international postgraduate university

The assessment of student learning driven by learning outcomes is often viewed as a tool to promote excellence in higher education. At the same time, many professors do not see a value in such approach, while nonetheless sincerely seeking to promote teaching and learning excellence. Is this a result of misunderstanding or is there an inherent conflict between a formalized assess- ment of learning

Navigating the dilemmas of climate policy in Europe: evidence from policy evaluation studies

Climate change is widely recognised as a 'wicked' policy problem. Agreeing and implementing governance responses is proving extremely difficult. Policy makers in many jurisdictions now emphasise their ambition to govern using the best available evidence. One obvious source of such evidence is the evaluations of the performance of existing policies. But to what extent do these evaluations provide i