Protein dynamics on the microsecond-millisecond time scales often play a critical role in biological function. NMR relaxation dispersion experiments are powerful approaches for investigating biologically relevant dynamics with site-specific resolution, as shown by a growing number of publications on enzyme catalysis, protein folding, ligand binding, and allostery. To date, the majority of studies

Achieving control of the crystal structure is essential in III-V nanowires, since twin defects, stacking faults and uncontrolled zincblende-wurtzite polytypism could have detrimental effects on the physical properties. In addition, precise control of the crystal phases also opens up the possibility of homomaterial bandgap engineering. Here, we show by ex situ chemical analysis of the alloy seed pa

The release of lactose (hydrophilic) from polymer tablets made with hydrophobically modified poly(acrylic acid) (HMPAA) have been studied and compared it to the release of ibuprofen, a hydrophobic active substance. Lactose is one of the most used excipients for tablets, but lactose release has not been widely studied. One reason could be a lack of good analytical tools. A novel biosensor with cell

Sexual conflicts and their evolutionary outcomes may be influenced by population-specific features such as mating system and ecological context; however, very few studies have investigated the link between sexual conflict and mating system. The self-compatible, mixed-mating hermaphrodite Collinsia heterophylla (Plantaginaceae) is thought to exhibit a sexual conflict over timing of stigma receptivi

Laser-induced incandescence (LII) as a diagnostic technique is based on rapid heating of soot particles to temperatures of several thousand Kelvin and subsequent detection of the thermal radiation from the laser-heated particles. At such high temperatures, soot sublimation effects must be considered when estimating uncertainties in LII measurements. In this work we have investigated the use of var

Objective: to explore midwives' awareness of and clinical experience regarding domestic violence among pregnant women in southern Sweden. Design: an inductive qualitative design, using focus groups interviews. Setting: midwives with experience of working in antenatal care (ANC) units connected to two university hospitals in southern Sweden. Participants 16 midwives recruited by network sampling an

Abstract Objective. This study examined whether age, gender, and comorbidity were of importance for an individual's choice of listing with either a public or a private primary health care (PHC) practice. Design and setting. The study was a register-based closed cohort study in one private and one public PHC practice in Blekinge County in southern Sweden. Subjects. A cohort (12 696 individuals) was

We propose a new dynamic hybrid logic to reason about social networks and their dynamics building on the work of “Logic in the Community” by Seligman, Liu and Girard. Our framework distinguishes between the purely private sphere of agents, namely their mental states, and the public sphere of their observable behavior, i.e., what they seem to believe. We then show how such a distinction allows our

CONTEXT: High-quality fatigue rating scales are needed to advance the understanding of fatigue and determine the efficacy of interventions. Several fatigue scales are used in Parkinson's disease, but few have been tested using modern psychometric methodology (Rasch analysis). OBJECTIVES: To examine the measurement properties of the generic Functional Assessment of Chronic Illness Therapy-Fatigue (

The autonomic nervous system plays an important role in the regulation of the urinary bladder function. Under physiological circumstances, noradrenaline, acting mainly on beta 3-adrenoceptors in the detrusor and on a1A-adrenoceptors in the bladder outflow tract, promotes urine storage, whereas neuronally released acetylcholine acting mainly on M3 receptors promotes bladder emptying. Under pathophy

Glaciomarine clay found west of Mt Billingen, central Sweden, contains two distinct varve units separated by a sand layer that we interpret to be sediment deposited in the North Sea during the catastrophic drainage of the Baltic Ice Lake (BIL). The lower varve series was deposited proximal to the retreating ice margin and consists of varves that grade upward from gray to red. The upper varve serie

We investigated whether BMI predicts type 2 diabetes in twins and to what extent that is explained by common genetic factors. This was a population-based twin cohort study. Monozygotic (n = 4,076) and dizygotic (n = 9,109) non-diabetic twin pairs born before 1958 answered a questionnaire in 1975, from which BMI was obtained. Information on incident cases of diabetes was obtained by linkage to nati

In this study we examined ecosystem respiration (R-ECO) data from 104 sites belonging to FLUXNET, the global network of eddy covariance flux measurements. The goal was to identify the main factors involved in the variability of R-ECO: temporally and between sites as affected by climate, vegetation structure and plant functional type (PFT) (evergreen needleleaf, grasslands, etc.). We demonstrated t

Measurements of a well-characterized 'standard' sample can verify the performance of an instrument. Typically, small-angle neutron scattering instruments are used to investigate a wide range of samples and may often be used in a number of configurations. Appropriate 'standard' samples are useful to test different aspects of the performance of hardware as well as that of the data reduction and anal

Abdominal sepsis is associated with significant changes in systemic inflammation and coagulation. The purpose of this study was to examine the role of peripheral blood monocytes for systemic coagulation, including thrombin generation and consumption of coagulation factors. Abdominal sepsis was induced by cecal ligation and puncture (CLP) in C57BL/6 mice. Plasma and lung levels of interleukin-6 (IL

Background In ROCKET AF, rivaroxaban was non-inferior to adjusted-dose warfarin in preventing stroke or systemic embolism among patients with atrial fibrillation (AF). We aimed to investigate whether the efficacy and safety of rivaroxaban compared with warfarin is consistent among the subgroups of patients with and without previous stroke or transient ischaemic attack (TIA). Methods In ROCKET AF,

Predators exert strong regulating forces on lower trophic levels through predation. As most fish are visual foragers, visual conditions in the water may alter the strength of this regulation. We evaluated effects of turbidity and humic water on foraging efficiency and prey-size selectivity in Northern pike (Esox lucius) feeding on roach (Rutilus rutilus). Encounter rates decreased in both turbid a