Aromatic side chains are prevalent in protein binding sites, perform functional roles in enzymatic catalysis, and form an integral part of the hydrophobic core of proteins. Thus, it is of great interest to probe the conformational dynamics of aromatic side chains and its response to biologically relevant events. Indeed, measurements of (13)C relaxation rates in aromatic moieties have a long histor

Background and purpose - Prosthetic joint infection (PJI) is a leading cause of early revision after total knee arthroplasty (TKA). Open debridement with exchange of tibial insert allows treatment of infection with retention of fixed components. We investigated the success rate of this procedure in the treatment of knee PJIs in a nationwide material, and determined whether the results were affecte

There are two main modes of replacement therapy for haemophilia patients: either to stop bleeding (on-demand) or regular infusions of clotting factor to prevent bleeds (prophylaxis). Fiftyyr of clinical experience have provided evidence of the superiority of prophylaxis by showing a reduction in bleeds and development of arthropathy. Prophylaxis has been described extensively in terms of efficacy

Motor complications in Parkinson's disease (PD) are associated with long-term oral levodopa treatment and linked to pulsatile dopaminergic stimulation. l-dopa-carbidopa intestinal gel (LCIG) is delivered continuously by percutaneous endoscopic gastrojejunostomy tube (PEG-J), which reduces l-dopa-plasma-level fluctuations and can translate to reduced motor complications. We present final results of

For the safety assessment of PHWR, it is required to study the flaw tolerance capacity of the pressure tubes as a function of the loading rate. In this work, the effect of loading rate and hydrogen content on the fracture behaviour of a Zr-2.5Nb alloy pressure tube was investigated between 25 and 300 degrees C. For the as received material, the pulling rate only had an effect on fracture toughness

X-ray spectroscopy studies of potassium intercalated metal-free phthalocyanine multilayers adsorbed on Al(110) have been undertaken. Photoelectron spectroscopy measurements show the presence of several charge states of the molecules upon K intercalation, due to a charge transfer from the alkali. In addition, the comparison of valence band photoemission spectra with the density functional theory ca

To investigate long-term suicide risk in individuals with no, one or more mental disorders.

An experimental investigation was performed for convective condensation ofR410A inside five micro-fin tubes with the same outer diameter of 5 mm and helix angle of 18°. Data are for mass fluxes ranging from about 180 to 650 kg/m2 s. The nominal saturation temperature is 320 K, with inlet and outlet qualities of 0.8 and 0.1, respectively. The results suggest that tube 4 has the best thermal perform

Objectives: Enteral exposure to the lectin phytohemagglutinin (PHA) provokes precocious gut maturation in suckling rats coinciding with an early expansion of intestinal mucosal T and B lymphocytes. Here, the role of the immune system in neonatal gut growth and maturation was further studied. Materials and Methods: The effects of immunosuppression by cyclosporine A (CyA), 7.5 mu g/g of body weight,

We performed a candidate gene association study in 540 patients with primary Sjogren's Syndrome (SS) from Sweden (n = 344) and Norway (n = 196) and 532 controls (n = 319 Swedish, n = 213 Norwegian). A total of 1139 single-nucleotide polymorphisms (SNPs) in 84 genes were analyzed. In the meta-analysis of the Swedish and Norwegian cohorts, we found high signals for association between primary SS and

A reactive hydride composite (RHC) with initial composition 3CaH(2) + 4MgB(2) + CaF2 was studied by in situ synchrotron radiation powder X-ray diffraction (SR-PXD) and X-ray absorption near edge structure (XANES) at the B K-edge and at the Ca K-edge. The hydrogenation reaction proceeds by an unknown intermediate. No evidence of intermediates was observed during the dehydrogenation reaction. B and

Animal vehicle collisions (AVC's) have large economic, medical and ecological consequences but have rarely been studied with respect to driver behaviour. The aim of this study was to investigate different AVC-relevant landscape settings (vegetation cover), with and without game fencing and in combination with encountering moose. Twenty-five participants took part in an advanced driving simulator e

A thermoelastic–plastic body consisting of two phases, a solid and a fluid, each comprising two constituents is considered where one constituent in one phase is allowed to exchange mass with another constituent (of the same substance) in the other phase. A large strain setting is adopted and the formulation applies to general anisotropy and the existence of residual stresses. Generalized forms of

. The aim of this article is to provide an up-to-date overview on paediatric haemophilia care in the world, with emphasis on medical treatment, rehabilitation, and orthopaedic surgery. The reason these specific professions caregivers are included is that over 90% of bleeding episodes in people with haemophilia (PWH) occur within the musculoskeletal system; and of these 80% of bleedings occur in jo

Deep brain stimulation (DBS) is a developing technology. New generations of DBS technology are already in the pipeline, yet this particular fact has been largely ignored among ethicists interested in DBS. Focusing only on ethical concerns raised by the current DBS technology is, albeit necessary, not sufficient. Since current bioethical concerns raised by a specific technology could be quite diffe

A palynological study of uppermost Maastrichtian to lower Paleocene marine strata from two stratigraphic sections in the Clarence Valley, Marlborough, New Zealand, revealed diverse organic-walled dinoflagellate cyst (dinocyst) assemblages. One hundred and twelve samples were investigated and 86 dinocyst species were identified, from the two sections studied: Branch and Mead streams. Nine new speci

Design inputs (wastewater characteristics, operational settings, effluent requirements or safety factors, ...) need to be supplied when using activated sludge process design guidelines (ASPDG) to determine the design outputs (biological reactor volume, the dissolved oxygen demand or the different internal/external recycle flow-rates). The values of the design inputs might have strong effects on th

The atmospheric concentration of elemental carbon (EC) in Europe during the six-year period 2005-2010 has been simulated with the EMEP MSC-W model. The model bias compared to EC measurements was less than 20% for most of the examined sites. The model results suggest that fossil fuel combustion is the dominant source of EC in most of Europe but that there are important contributions also from resid

To study the prevalence of chronic widespread pain (ChWP), chronic regional pain (ChRP), and fibromyalgia in patients with early rheumatoid arthritis (RA) followed for 5 years after inclusion, and to study the effect of pain on measures of disease activity and function.