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Dynamics of single enzymes confined inside a nanopore

Enzymes are powerful catalysts that perform chemical reactions with remarkable speed and specificity. Their intrinsic dynamics often play a crucial role in determining their catalytic properties. To achieve a comprehensive understanding of enzymes, a diverse and sophisticated experimental toolbox capable of studying enzyme dynamics at the single-molecule level is necessary. In this review, we disc

Health care benefits package design to improve outcomes in resource-constrained settings : suggestions for Tajikistan

The Tajik health system is characterized by improving health outcomes over the last 20 years, but also major inefficiencies in health care delivery and large difficulties for people to access affordable essential health care. The benefits package (BP) is a key tool for prioritizing state budget allocations toward health interventions that most effectively enhance health system performance. This ar

Between speed and safeguards : evaluating equity in the EU's carbon capture and storage policy landscape

As part of the Net-Zero Industry Act and Industrial Carbon Management Strategy, the European Union (EU) has positioned carbon capture and storage (CCS) as a critical decarbonization technology. These developments build on the European Green Deal's (EGD) integrated approach to climate policy, which seeks to balance decarbonization with broader societal goals. Previous research confirms CCS's techni

Challenges in population monitoring : Bar-tailed Godwits (Limosa lapponica) on the East Atlantic Flyway defy assumed population structure

Estimating and monitoring migratory bird populations involves significant challenges, even in the most well-studied and easily-counted species, and can be further complicated by long-held but unverified assumptions and by shifting distributions in changing flyway conditions. We illustrate these challenges using Bar-tailed Godwits Limosa lapponica on the East Atlantic Flyway. The subspecies L. l. l

Structure of highly concentrated aqueous electrolyte solutions of transition metal chlorides and bromides

The structures of the complexes dominating in highly concentrated and 1.0 mol dm−3 aqueous solutions of first-row transition metal chlorides and bromides have been studied using large angle X-ray scattering (LAXS) and/or EXAFS. Of these systems, only zinc(ii) chloride and bromide form inner-sphere complexes in dilute aqueous solutions. No inner-sphere complexes corresponding to dilute aqueous perc

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The purpose of this study is to examine the effect of care workers employment characteristics and perception of facility directors’ transformational leadership on quality of service through a hierarchical linear model. For this aim, survey data were collected amongst 240 lder adults and 200 care workers who are affiliated within 45 long-term care facilities in Seoul, and analyzed using SPSS 26.0 a

Effects of levodopa–entacapone–carbidopa intrajejunal infusion on non-motor symptoms of advanced Parkinson’s disease—interim analysis of the ELEGANCE study

The ELEGANCE study (NCT05043103) is an ongoing, non-interventional registry study collecting real-world data on long-term efficacy, safety and patient-reported outcomes following treatment with levodopa–entacapone–carbidopa intestinal gel (LECIG) infusion. To explore the effect of LECIG on non-motor symptoms (NMS) in advanced Parkinson’s disease patients participating in the ELEGANCE study and usi

Diverse nitrogen acquisition strategies of conifer-associated ectomycorrhizal fungi shape unique responses to changing nitrogen regimes

Ectomycorrhizal fungi are critical mediators of nitrogen acquisition in forest ecosystems, exhibiting variation in both host association and metabolic traits that mediate differential responses to forest nitrogen availability. However, how nitrogen acquisition strategies vary among closely related fungal species, how these patterns manifest in conifer-associated ECM fungi, and whether they persist

Elevated levels of TRAb IgG autoantibodies are not recognized in endometriosis by the current clinical methods

Background: Endometriosis can cause gastrointestinal symptoms that sometimes lead to incorrect diagnosis of irritable bowel syndrome (IBS). Receptors of thyroid-stimulating hormone (TSH) are found in the endometrium and are overexpressed in ectopic endometrium. The role of TSH receptors and thyroid hormones in the pathophysiology of endometriosis has therefore been discussed. No biomarker is avail

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The purpose of this study is to compare and analyze cash-for-care regulatory policies for the elderly long-term care in three countries, Germany, Sweden, and the UK, and to seek policy implications in preparation for regulatory policies that are suitable for the direction of South Korea’s welfare state and the socio-cultural environment. For this purpose, each country’s cash-for-care regulatory po

Spin Matters : A Multidisciplinary Roadmap to Understanding Spin Effects in Oxygen Evolution Reaction During Water Electrolysis

A central challenge in water electrolysis lies with the oxygen evolution reaction (OER) where the formation of molecular oxygen (O2) is hindered by the constraint of angular momentum conservation. While the reactants OH− or H2O are diamagnetic (DM), the O2 product has a paramagnetic (PM) triplet ground state, requiring a change in spin configuration when being formed. This constraint has prompted

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The article aims to shed light on the role of informality in the survival strategies of Ukrainian refugees who arrived in France since 2022. Informal solutions are common in everyday interactions within Ukrainian society and are also often used by migrant populations. However, they are not always embraced by Ukrainian refugees in France. The fieldwork conducted across three French regions connects

Differences Between Sweden and Greece in Joint Outcomes Assessed by Ultrasound in Adolescents With Severe Haemophilia on Prophylaxis : Data From the PedNet Registry

Introduction: Different strategies in prophylaxis for haemophilia among countries may affect long-term outcome. Aim: The aim of this study is to compare joint health in persons with severe haemophilia (PwSH) between Sweden and Greece, based on different approaches on prophylaxis initiation and management. Methods: Data were extracted from the PedNet Registry, which collects patient data prospectiv

Threats, emotional reactions and affective polarization

In this chapter, we discuss threats and emotions as drivers of affective polarization. We base our discussion on Social Identity Theory and Intergroup Threat Theory, with the basic idea that threats posed by other social groups strengthen intergroup differentiation. Drawing on intergroup threat theory, we argue that when individuals perceive an outgroup threatens the ingroup, they will react with