Background Signal transduction pathways convey information from the outside of the cell to transcription factors, which in turn regulate gene expression. Our objective is to analyze tumor gene expression data from microarrays in the context of such pathways. Results We use pathways compiled from the TRANSPATH/TRANSFAC databases and the literature, and three publicly available cancer microarray da

Formulating and implementing a new strategy may be a challenging task, especially if it alters the way in which a company has operated and positioned itself before. This may be particularly true for companies within the forest industry, like manufacturers of paper packaging products, pursuing differentiated customer value and innovative solutions where, traditionally, success has been measured in

A 38-year record of bottom water dissolved oxygen concentrations in coastal marine ecosystems around Denmark (1965-2003) and a longer partially reconstructed record of total nitrogen (TN) inputs (1900-2003) were assembled to describe long-term patterns in hypoxia and anoxia. Interannual variations in bottom water oxygen concentrations were analyzed in relation to various explanatory variables (bot

Apolipoprotein A-I (apoA-I) is the major protein component of high density lipoproteins (HDL) and plays a central role in cholesterol metabolism. The lipid-free/lipid-poor form of apoA-I is the preferred substrate for the ATP-binding cassette transporter A1 (ABCA1). The interaction of apoA-I with ABCA1 leads to the formation of cholesterol laden high density lipoprotein (HDL) particles, a key step

BACKGROUND: We have conducted a randomized controlled trial of totally extraperitoneal hernia repair (TEP) versus tension-free open repair (Lichtenstein repair); we have presented the results previously up to 1 year after the operation. The aim of this study was to compare patient outcome in both groups at a median follow-up of 7.3 years after operation. METHODS: Of 168 patients included in a pros

The increased incidence of multiple myeloma (MM) across China and East Asia stimulated us to examine the current rates in Great Britain, where rates increased dramatically in the second half of the 20th century. However, rates have been stable and high during this period in Malmö, Sweden, where there is a keen interest in MM. We thus assessed recent changes in MM incidence in Great Britain, Sweden

ABSTRACT: BACKGROUND: Today, no objective criteria exist to differentiate between individual primary tumors and intra- or intermammary dissemination respectively, in patients diagnosed with two or more synchronous breast cancers. To elucidate whether these tumors most likely arise through clonal expansion, or whether they represent individual primary tumors is of tumor biological interest and may

Denna artikel bygger på en dubbelföreläsning vid LMS språkdagar den 3 april 2011 på Högskolan i Halmstad. Målgruppen var 20 modersmålslärare i arabiska. Efter en historisk översikt av den moderna arabiska litteraturen under de senaste tvåhundra åren tog jag upp utvecklingen av den arabiska romanen från Zaynab: Lantliga scener och sedvänjor (1913) av den egyptiske författaren Muhammad Husayn Haykal

In this thesis we study several combinatorial problems in algorithmic graph theory and computational biology, and different algorithmical approaches for solving them. In particular, we focus on graph algorithms, seeking for the most part polynomial or sub-exponential exact solutions, but in some cases also approximate solutions. In the first part we study two problems on phylogenetic trees, the pr

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Interview with Saskia Sassen about globalization, liberalism and democracy.

Rational, autonomous agents that are able to achieve their goals in dynamic, partially observable environments are the ultimate dream of Artificial Intelligence research since its beginning. The goal of this PhD thesis is to propose, develop and evaluate a framework well suited for creating intelligent agents that would be able to learn from experience, thus becoming more efficient at solving thei

OBJECTIVES: Exposure to antineoplastic drugs should be avoided due to the risk of getting adverse health effects. Antineoplastic drugs such as cyclophosphamide (CP) and ifosfamide (IF) are commonly used in medical attendance. In this study the variability of surface contamination of CP and IF was investigated by repeated wipe sampling over time in four workplaces in a university hospital. The surf

Sleep restrictions and sleep deprivation have become common in modern society, as many people report daily sleep below the recommended 8 hours per night. This study aimed to examine the effects of sleep deprivation on oculomotor performance by recording smooth pursuit and saccadic eye movements after 24 and 36 hours of sleep deprivation. Another objective was to determine whether detected changes

Considerable effort has been dedicated over the years to model and simulate the ultrafiltration process. Most approaches are theoretical and therefore not applicable to industrial process streams. When treating such solutions, a combination of experiments and simulations is needed. In this thesis, a method has been developed for design and optimization of UF plants. The method uses experiments in