An aminoglycoside in combination with a beta-lactam antibiotic is often recommended for the treatment of severe infections. The aim of the present study was to study whether cefuroxime-induced endotoxin release could be reduced by addition of tobramycin in different Gram-negative bacteria and how endotoxin release was affected by bacterial killing rate and number of killed bacteria. Three Escheric

Popular Abstract in Swedish I kopplingsanalys, eller i en något mera generell mening vid genletning, så söker man efter sjukdomsgener längs ett genom. Här kan man tolka ett genom som en mängd av hela, eller bitar av, olika kromosomer. Med avseende på en mängd sammanhängande flergenerationella släkter så observerar man då, längs genomets kromosombitar, markördata, dvs genotyper bestående av nedärvdIn linkage analysis or, in a wider sense, gene mapping one searches for disease loci along a genome. This is done by observing so called marker genotypes (alleles) and phenotypes (affecteds/unaffecteds) of a pedigree set, i.e. a set of multigenerational families, in order to locate the loci corresponding to the underlying disease genes or, at least, to narrow down the interesting genome regions. I

During the early 1990s, a novel style of programming often referred to as component-oriented programming quickly grew popular as the state-of-the-art in graphical user interface and client/server development on Windows-based personal computers, largely in competition with object-oriented programming, a partly similar, partly different programming paradigm, with which component-orientation is often

Ecosystems along the 0degreesC mean annual isotherm are arguably among the most sensitive to changing climate and mires in these regions emit significant amounts of the important greenhouse gas methane (CH4) to the atmosphere. These CH4 emissions are intimately related to temperature and hydrology, and alterations in permafrost coverage, which affect both of those, could have dramatic impacts on t

In October 1992, severe dilatation of the right atrium was detected in a 35 week foetus. The septal leaflet of the tricuspid valve seemed to be displaced distally causing massive tricuspid regurgitation. The diagnosis of Ebstein's anomaly was made and confirmed after birth. Refractory right heart failure occurred at the age of 10 months and the little girl was operated. At surgery, the right atriu

Several receptors activated by extracellular nucleotides (ATP, ADP, UTP and UDP) have recently been cloned. These P2 receptors mediate a multitude of cardiovascular effects such as positive inotropic effects in the heart, platelet aggregation, release of endothelial factors, growth stimulation of vascular smooth muscle cells, vasomotor effects and blood pressure regulation. The physiological and p

Objectives: With the introduction of sildenafil citrate (VIAGRA (TM)), the concept of phosphodiesterase (PDE) inhibition has gained tremendous interest in the field of urology. Cyclic nucleotide second messengers cGMP and cAMP have been assumed to be involved in the control of the normal function of the prostate. The aim of the present study was to evaluate by means of immunohistochemistry the exp

Several studies have used artificial neural networks (NNs) to estimate local or regional recipitation/rainfall on the basis of relationships with coarse-resolution atmospheric variables. None of these experiments satisfactorily reproduced temporal intermittency and variability in rainfall. We attempt to improve performance by using two approaches: (1) couple two NNs in series, the first to determi

Transplantation of embryonic human neural tissue can restore dopamine neurotransmission and improve neurological function in patients with Parkinson's disease. Logistical and ethical factors limit the availability of human embryonic allogeneic tissue. Embryonic xenogeneic neural tissue from porcine donors is an alternative form of donor tissue, but effective immunomodulatory techniques are warrant

Popular Abstract in Swedish Modelleringsarbetet utvecklat i denna avhandling, kan delas in i två huvudområden: självantändning i ottomotorer, samt förbränning och emissioner i dieselmotorer. En första version av ett motorsimuleringsprogram med detaljerad kemisk kinetik, utökad för att innefatta full-cykel beräkningar, användes för att visa den starka påverkan som kväveoxider i restgaser har på sjThe modeling work developed in this thesis can be divided in two main areas of investigations: autoignition related to spark ignition engine and combustion and emissions formation in relation to diesel engines. A first version of a detailed kinetics engine simulation program, extended to handle full cycle calculations, was employed in order to demonstrate the strong effect that nitric oxide from

Background and aims: In the elderly, balance and walking impairments are assumed to play an important role in causing falls. We have assessed prospectively the predictive ability of health, function and balance variables regarding falls and their location. Methods: Falls which occurred during one year in a random sample of 307 women aged 75 years and over (mean 80.8 years, response rate 74.5%) liv

The isotope Ag-105 has been studied using 169.5 MeV Cl-37 ions impinging on Ge-76. The Nordball Ge array detected the gamma rays and a 4 pi charged particle detector system detected emitted light charged particles. A very deformed band has been established using Doppler shift attenuation methods. The analysis is based on the gamma gamma coincidences and the angular dependence of the four rings of

Rheumatoid arthritis is a chronic inflammatory disease associated with certain HLA-DR4 subtypes. The target autoantigen(s) is unknown, but type II collagen (CII) is a candidate, with a single immunodominant DR4-restricted 261-273 T cell epitope (CII(261273)). In the present study, we have prepared HLA-DR4:CII(261-273) tetramers and analyzed peripheral blood, lymph node, and synovial fluid cells fr

The paper describes the spectrometric system "SPES4-pi" used at the National Laboratory Saturne (CE Saclay, France) for the exclusive study of the baryon resonance excitation in inelastic alpha and d scattering on the proton, as well as coherent pion production in charge exchange reactions. The system consists of the magnetic spectrometer SPES4 and two wide-aperture position-sensitive detector arr

The paper suggests an explicit form of a general integral of motion for some classes of dynamical systems including n-degree-of-freedom mechanical systems subject to (n-1) virtual holonomic constraints. The computation of this integral opens several possibilities for generating and further exponential orbital stabilization of solutions in nonlinear feedback systems. An illustrative example is give

Various types of silicon material and silicon p(+)n diodes have been treated to increase the concentration of the oxygen dimer (02) defect. This was done by exposing the bulk material and the diodes to 6 MeV electrons at a temperature of about 350 degrees C. FTIR spectroscopy has been performed on the processed material confirming the formation of oxygen dimer defects in Czochralski silicon pieces

We describe the detectors for identification of charged particles and fragments in CHICSi, a large solid angle multitelescope system mounted inside an ultra-high vacuum (UHV), cluster-jet target chamber. CHICSi performs nuclear reaction experiments at storage rings. The telescopes consist of a first very thin, 10-14 mum Si detector, a second 300 mum (or possibly 500 pm) ion implanted Si detector s