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Synthesis of Spiro-bicyclo[2.2.2]Octane Derivatives Towards the Development of Paclitaxel Mimetics

Popular Abstract in Swedish Många av de föreningar som utvecklas i den farmaceutiska industrin idag har sina rötter i naturprodukter. Paclitaxel, den aktiva substansen i läkemedlet Taxol, återfinns bland annat i idegranens bark. Detta upptäcktes i början av 1960-talet då ett nationellt sökprogram för att finna nya naturprodukter för användning mot cancer organiserades i Amerika. Den låga halten avMany of the drugs that are developed in the pharmaceutical industry have their origin in natural products. Paclitaxel, the active substance of the medicine Taxol, was found in the bark of the Pacific yew tree (Taxus brevifolia). This was discovered in the early 1960's when a screening program was initiated by the National Cancer Institute (NCI) in the US, with the aim to find new natural products

Global Climate Governance beyond 2012: an Introduction

Future historians might remember the period 2009-2012 as a turning point in the political response to global warming and climate change. The 1980s were a time of agenda-setting in which climate change became accepted as a political problem; the 1990s saw the first institutionalization through adoption of the United Nations Framework Convention on Climate Change in 1992 and its Kyoto Protocol in 19

SI vid LTH: Rapport om SI-verksamheten vid LTH 2011/12-2013/14

Supplemental Instruction (SI) är som framgår av namnet ett komplement till den ordinarie undervisningen i en kurs. Tanken med SI är att inlärningen av ett ämne förstärks genom utbyte av tankar och idéer mellan studenterna. Vid LTH är SI-verksamheten knuten till en initiell ”svår” kurs för nybörjarstudenter. SI sker i möten om ca 5-15 studenter där diskussionen leds av en äldre student. Den äldre s

Protein aggregation: Computational modeling and Monte Carlo algorithm development

Popular Abstract in Icelandic Við könnumst flest öll við prótín (eggjahvítuefni) af innihaldslýsingu hvers kyns matvæla. En prótín eru annað og meira en bara orkugjafi. Prótín gegna fjölmörgum veigamiklum hlutverkum í nær öllum líffræðilegum ferlum. Þau hraða ýmsum efnahvörfum, flytja efni í gegnum frumuhimnur, aðstoða við boðskipti bæði innan og á milli fruma, og gegna mikilvægu hlutverki í starfAlthough organisms have evolved sophisticated cellular mechanisms for regulating their various protein networks, proteins sometimes start to clump together in an uncontrolled way. The aggregation of proteins has been associated with a range of serious diseases. In this thesis we develop and apply theoretical computer models to investigate different aspects of the aggregation process, and its under

The Effect of Jus Cogens Norms: : Whoever Opened the Pandora’s Box, Did You Think About the Consequences?

This article forms a contribution to the ongoing scholarly debate on the possible effect of jus cogens norms. For the purpose of the article, it is assumed that peremptory norms certainly exist in positive international law. According to the argument, even if we limit the effects of jus cogens norms to those described in the 1969 Vienna Convention, the jus cogens concept takes us farther than most

Sohlberg och surdegen : sociala relationer på Kosta glasbruk 1820-1880

Popular Abstract in Swedish I avhandlingens fokus står förhållandena på Kosta glasbruk under perioden 1820-1880. Glasbruket som grundades år 1742 är en av de många mindre svenska bruksbildningarna. Under hela undersökningsperioden måste glasbruket ses som förhållandevis litet med som mest ett 80-tal hushåll direkt knutna till glasbrukets industriproduktion. Glasbruket hade liksom flertalet svenskaThis thesis focuses on the circumstances at the glassworks of Kosta during the years 1820-1880. The glassworks founded there in 1742 was but one of many small Swedish rural works. Throughout the period in question, the glassworks can be seen as a small-scale factory with about 80 households directly engaged in industrial production. Like the rest of the glass industry, the glassworks at Kosta deve