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Background: Regular monitoring of healthcare quality and equity is crucial for informing decision-makers and clinicians. This study explores the application of generative AI, more specifically large language models (LLMs), to facilitate standardized monitoring of healthcare quality using the established framework Analysis of Individual Heterogeneity and Discriminatory Accuracy (AIHDA). The study i

This article summarizes the current understanding of the heterogeneity of type 1 diabetes from a June 2024 international Expert Forum organized by the editors of Diabetes, Diabetes Care, and Diabetologia. The Forum reviewed key factors contributing to the development and progression of type 1 diabetes and outlined specific, high-priority research questions. Knowledge gaps were identified, and, not

This article summarizes the current understanding of the heterogeneity of type 1 diabetes from a June 2024 international Expert Forum organized by the editors of Diabetes, Diabetes Care, and Diabetologia. The Forum reviewed key factors contributing to the development and progression of type 1 diabetes and outlined specific, high-priority research questions. Knowledge gaps were identified, and, not

This article summarises the current understanding of the heterogeneity of type 1 diabetes from a June 2024 international Expert Forum organised by the editors of Diabetes, Diabetes Care, and Diabetologia. The Forum reviewed key factors contributing to the development and progression of type 1 diabetes and outlined specific, high-priority research questions. Knowledge gaps were identified and, nota

BACKGROUND: Patients presenting with an acutely painful swollen joint represent a diagnostic challenge. We aimed to develop a clinical prediction model for septic arthritis (SA) in the adult native knee.METHODS: We screened all synovial cultures in south Sweden in 2020 and 2021. We included cultures taken in the emergency department from adults' native knees where SA was considered a differential

Placing concrete using a truck-mounted pump is a common construction method, enabling pouring of large volumes of concrete in a highly efficient way. However, the method is associated with unfavorable working conditions due to the need for manual handling of the end-hose. The hose-man are exposed to hazardous and poor working conditions. This paper reports on efforts to develop a robotic system foPlacing concrete using a truck-mounted pump is a common construction method, enabling pouring of large volumes of concrete in a highly efficient way. However, the method is associated with unfavorable working conditions due to the need for manual handling of the end-hose. The hose-man are exposed to hazardous and poor working conditions. This paper reports on efforts to develop a robotic system fo

Hydrodynamic cavitation take place in high-pressure homogenizer (HPH) valves. Cavitation wear, free radical formation and ultrasonic emissions are linked to the cavitation intensity. Cavitation intensity is also a key factor to understand any effect cavitation might have on particle breakup. Based on an approach used in previous studies on other devices, this contribution applies and tests a model

This paper aims to identify and analyse the key drivers affecting the adoption of Industry 5.0 (I5.0) technologies in the dairy industry. The data collected from various dairy stakeholders was analysed using Exploratory Factor Analysis (EFA) to uncover the underlying factors, and Multiple Linear Regression (MLR) was employed to evaluate the impact of the factors on the adoption level of I5.0 techn

INTRODUCTION: Structural magnetic resonance imaging (MRI) often lacks diagnostic, prognostic, and monitoring value in Alzheimer's disease (AD), particularly in early disease stages. To improve its utility, we aimed to identify optimal atrophy markers for different intended uses.METHODS: We included 363 older adults; cognitively unimpaired individuals who were negative or positive for amyloid beta

INTRODUCTION: A granular understanding of the mechanisms linking tau pathology to cognitive decline in Alzheimer's disease is crucial. We investigate mediating effects of medial temporal lobe (MTL) and neocortical neurodegeneration on tau-induced domain-specific cognitive impairment in amyloid-beta (Aβ) positive cognitively normal and impaired adults.METHODS: We assessed magnetic resonance imaging

The anterior portion of the medial temporal lobe (MTL) is one of the first regions targeted by pathology in sporadic Alzheimer's disease (AD) and limbic-predominant age-related TDP-43 encephalopathy (LATE) indicating a potential for metrics from this region to serve as imaging biomarkers. Leveraging a unique post-mortem dataset of histology and magnetic resonance imaging (MRI) scans, we aimed to (