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Purpose: To characterise the baseline clinical features and genotypes of adults with pre-mRNA processing factor 31 (PRPF31)-associated retinal dystrophy (RD) enrolled in a prospective, multicentre 4-year natural history study, and to explore correlations between selected baseline parameters. Methods: Thirty-one patients with PRPF31-RD underwent comprehensive multimodal assessment, including slit-l

Vacuum membrane distillation is a promising technology for seawater desalination, as it enables high recovery ratios, with reasonable thermal and minimal electric consumption. Ceramic membranes can offer notable advantages over polymeric membranes, mainly due to their robust thermal and mechanical stability, yet they have limited representation in the literature. Accordingly, this work investigate

Overdischarge poses severe challenges to the structural integrity and electrochemical performance of layered LiNixCoyMn1-x-yO2 (NCM) cathodes in lithium-ion batteries, yet the underlying degradation mechanisms remain insufficiently understood. Through a combined experimental and theoretical approach, this study systematically investigates how overdischarge destabilizes NCM cathodes with varying tr

The Aerosol, Clouds and Trace Gases Research Infrastructure (ACTRIS) officially became the 33rd European Research Infrastructure Consortium (ERIC) on 25 April 2023 with the support of 17 founding member and observer countries. As a pan-European legal organization, ACTRIS ERIC will coordinate the provision of data and data products on short-lived atmospheric constituents and clouds relevant to clim

Chapter 3 examines the techniques and elements of paramilitarism through the intersections of both domestic and foreign policy. By focusing on extralegal activities as a derivative of state violence, the interactions between domestic and foreign policy and the continuities of unconventional warfare are analyzed. Specifically, it explores how Turkey has acquired and transformed modern forms of unco

Background: The combination of hematuria, proteinuria and a reduced glomerular filtration rate (GFR) in patients with no previous diagnosis of chronic kidney disease is widely considered a strong indication for kidney biopsy. This study aimed to compare the frequencies of diseases leading to this symptom constellation, and to explore differences related to age and sex using data from kidney biopsy

Context. Since the discovery of the first exoplanet almost three decades ago, the number of known exoplanets has increased dramatically. By beginning of the 2000s it was clear that dedicated facilities to advance our studies in this field were needed. The CHaracterising ExOPlanet Satellite (CHEOPS) is a space telescope specifically designed to monitor transiting exoplanets orbiting bright stars. I

Background: Stroke is a leading cause of death and disability worldwide. While personality traits have been associated with various health outcomes, their association with stroke remains underexplored. Methods: This is a cross-sectional study based on wave 9 data from the Survey of Health, Ageing and Retirement in Europe (SHARE). Individuals aged 50 years or older were included in the study. The B

Background: Generating parasite genomes is challenging when little of the DNA in infected host tissue is from the parasite. We used selective whole genome amplification (SWGA) to generate genomic data from wildlife samples of the avian haemosporidian Haemoproteus majoris (lineage PARUS1) and its host, the blue tit (Cyanistes caeruleus). Methods: We used SWGA to amplify the parasite DNA in nine avi

Background and aims: Animal studies have suggested that high salt intake might increase the risk of metabolic dysfunction-associated steatotic liver disease (MASLD), but results from populations are mixed, in part due to inadequate salt intake measurement. Salty taste preference is the primary factor leading to salt choice and can reflect habitual salt intake. However, no study has investigated t

I artikeln presenterar forskarna Tillsammans-projektet, som syftar till att förbättra socialt stöd genom samverkan mellan civilsamhället och vården. Projektet bygger på community connector-modellen, där en samhällskontakt agerar som mellanhand för att koppla patienter till stöttande resurser. Modellen, som utvecklats genom workshops, strävar efter att skapa ett mer omfattande stöd utanför vården, I artikeln presenterar forskarna Tillsammans-projektet, som syftar till att förbättra socialt stöd genom samverkan mellan civilsamhället och vården. Projektet bygger på community connector-modellen, där en samhällskontakt agerar som mellanhand för att koppla patienter till stöttande resurser. Modellen, som utvecklats genom samskapande workshops, strävar efter att skapa ett mer omfattande stöd utan

As phylogenetically basal metazoans, sponges (phylum Porifera) provide crucial insights into the origins of animal biomineralization and early body plan innovation. However, articulated sponge fossils remain exceptionally rare in Ediacaran–Cambrian transition strata, with most records limited to isolated spicules or ambiguous biomineralized structures. This study reports siliceous and phosphatical

Precision measurements of electron reconstruction, identification, and isolation efficiencies and photon identification efficiencies are presented. They use the full Run 2 data sample collected by the ATLAS experiment in pp collisions at a centre-of-mass energy of 13 TeV during the years 2015–2018, corresponding to an integrated luminosity of 139 fb−1. The measured electron identification efficien

Denna studie undersöker de interpretativa och tekniska krav som ställs på violinisten i Alfred Schnittkes Concerto Grosso nr. 1, med särskilt fokus på verkets dialog mellan det förflutna och nutiden. Genom en detaljerad analys av violindelarna utforskar forskningen avancerade stråk-, artikulations- och intonationsstrategier som krävs för framförandet, samt effektiva övningsmetoder. Den formella anThis study explores the interpretative and technical demands placed on the violinist in Alfred Schnittke’s Concerto Grosso No. 1, with particular attention to the work’s dialogue between past and present. Through a detailed examination of its violin parts, the research investigates advanced bowing, articulation, and intonation strategies required for performance, as well as efficient practice meth

Colour clines constitute an interesting topic of study for evolutionary ecologists as they allow for the testing of different hypotheses on the adaptive value of colour variation. One possible explanation for the selective advantage of colouration is crypsis. In Littorina saxatilis from the Rías Baixas (northwest Iberian Peninsula), a temporally stable and spatially recurrent colour cline has been

Background: Despite its prominent role in contemporary biology and science, the theory of evolution is still contested by many social groups, showing a deficient understanding of its central postulates and low acceptance rates in many countries. A region traditionally understudied in this respect is Latin America. Within this region, Ecuador stands out as a key territory in the history of evolutio

Since their inception, ecology and evolutionary biology have been filled with controversies. While controversies are generally beneficial, they can sometimes hinder meaningful communication and, ultimately, decelerate scientific advancement. A clear example is when scientific rivals enter a point-scoring mode in which proving the opponent wrong sidelines objective assessments. To counter this, we

Human-induced habitat loss, fragmentation and degradation are among the leading causes of species decline worldwide. This is particularly true in tropical forests, where unique, often highly specialized fauna is under threat. By altering resource availability, anthropogenic habitat change can impose resource constraints on animals and may influence their allocation of resources to competing life h