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Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study

Beulens JWJ, van der Schouw YT, Bergmann MM, Rohrmann S, B Schulze M, Buijsse B, Grobbee DE, Arriola L, Cauchi S, Tormo M-J, Allen NE, van der A DL, Balkau B, Boeing H, Clavel-Chapelon F, de Lauzon-Guillan B, Franks P, Froguel P, Gonzales C, Halkjaer J, Huerta JM, Kaaks R, Key TJ, Khaw KT, Krogh V, Molina-Montes E, Nilsson P, Overvad K, Palli D, Panico S, Ramon Quiros J, Ronaldsson O, Romieu I, Ro

Osteoporosis and periodontitis in older subjects participating in the Swedish National Survey on Aging and Care (SNAC-Blekinge)

Objective. We assessed the relationships between (I) ultrasonography calcaneus T-scores (PIXI) and mandibular cortex characteristics on oral panoramic radiographs in older subjects; and (II) osteoporosis and periodontitis. Material and methods. We examined 778 subjects (53% women) aged 59-96 years. Periodontitis was defined by alveolar bone loss assessed from panoramic radiographs. Results. PIXI c

Class-D CMOS Oscillators

This paper presents class-D CMOS oscillators capable of an excellent phase noise performance from a very low power supply voltage. Starting from the recognition of the time-variant nature of the class-D LC tank, accurate expressions of the oscillation frequency, oscillation amplitude, current consumption, phase noise, and figure-of-merit (FoM) have been derived. Compared with the commonly used cla

Switchable Frequency Selective Surface for Reconfigurable Electromagnetic Architecture of Buildings

A frequency selective surface (FSS) that is electronically switchable between reflective and transparent states is tested. It can be used to provide a spatial filter solution to reconfigure the electromagnetic architecture of buildings. The FSS measurements show that the frequency response of the filter does not change significantly when the wave polarization changes or the angle of incidence chan

Drug therapy - a challenge in primary care.

Popular Abstract in Swedish Bakgrund: Förskrivning av läkemedel är en av de vanligaste medicinska åtgärderna men samtidigt den största orsaken till patientskador och patientsäkerhetsproblem i Sverige. Läkemedelsbehandling av multisjuka äldre och förskrivning av antibiotika mot okomplicerade luftvägsinfektioner är två områden där patientsäkerhetsproblem har uppmärksammats. Behandling med potentiellIntroduction: Drug therapy in primary care is a broad field, with two areas previously identified as particularly challenging: treatment of the elderly and prescription of antibiotics against uncomplicated upper respiratory tract infections (URTIs). General practitioners’ (GPs’) attitudes and adherence to evidence-based treatment guidelines might be influenced by different interventions and need t

Bioactive Lipids in Nociception

This thesis focuses on bioactive lipids as (1) metabolites of the widely used antipyretic and analgesic drug acetaminophen and (2) activators of the ion channel TRPV1, an important downstream target for inflammatory mediators, in the phospholipase C (PLC)/TRPV1 signaling pathway. Evidence is presented for a fatty acid amide hydrolase (FAAH)-dependent fatty acid conjugation of p-aminophenol, a know

Exploring the two-gene ratio in breast cancer-independent roles for HOXB13 and IL17BR in prediction of clinical outcome

BACKGROUND: The two-gene expression ratio HOXB13:IL17BR has been proposed to predict the outcome of tamoxifen-treated breast cancer patients. We intended to examine whether this ratio can predict the benefit of 5 years vs. 2 years of tamoxifen treatment of postmenopausal patients. A further objective was to investigate any prognostic effects of the ratio in systematically untreated premenopausal p

Calculation of Protein-Ligand Interaction Energies by a Fragmentation Approach Combining High-Level Quantum Chemistry with Classical Many-Body Effects

We have developed a method to estimate accurate interaction energies between a full protein and a bound ligand. It is based oil the recently proposed PMISP (polarizable multipole interaction with supermolecular pairs) method (Soderhjelm, P.; Ryde, U. J. Phys. Chem. A 2009, 113. 617), which treats electrostatic interaction by multipoles up to quadrupoles, induction by anisotropic polarizabilities,

A 1.6-2.6GHz 29dBm Injection-Locked Power Amplifier with 64% peak PAE in 65nm CMOS

This paper presents a wideband CMOS power amplifier intended for cellular handset applications. The circuit exploits injection locking to achieve a power gain of 20.5dB from a single stage amplifier. The maximum output power of 29dBm, with a peak drain- and power-added-efficiency (PAE) of 66% and 64%, respectively, occurs at a center frequency of 2GHz with a 3V supply. A cross-coupled cascode topo

Abdominal Aortic Aneurysm – Different Aspects on Screening

Popular Abstract in Swedish Populärvetenskaplig sammanfattning på svenska (Comprehensive summary in Swedish) Stora kroppspulsådern är det centrala kärl som från hjärtat leder blodet vidare till kroppens alla organ. När kroppspulsåderns kärlvägg försvagas resulterar detta i en utvidgning (bråck). Ett kroppspulsåderbråck sitter vanligtvis i nivå med naveln, strax nedom kärlen som försörjer njurarnaAbstract Abdominal aortic aneurysm (AAA) is a hideous life threatening disease that most often is asymptomatic until it ruptures. Ruptured abdominal aortic aneurysm (rAAA) is a painful and serious predicament with a mortality of 80-90%. Half of the patients die before arriving to hospital, leaving family members in sorrow and shock. In Sweden about 700-1000 patients die each year due to rAAA, cor

Search for contact interactions and large extra dimensions in the dilepton channel using proton-proton collisions at root s=8 TeV with the ATLAS detector

A search is conducted for non-resonant new phenomena in dielectron and dimuon final states, originating from either contact interactions or large extra spatial dimensions. The LHC 2012 proton-proton collision dataset recorded by the ATLAS detector is used, corresponding to 20 fb(-1) at root s = 8 TeV. The dilepton invariant mass spectrum is a discriminating variable in both searches, with the cont

Water management in cities of the future using emission control strategies for priority hazardous substances

Cities of the future face challenges with respect to the quantity and quality of water resources, and multiple managerial options need to be considered in order to safeguard urban surface water quality. In a recently completed project on 'Source control options for reducing emissions of Priority Pollutants' (ScorePP), seven emission control strategies (ECSs) were developed and tested within a semi

Deletion of integrin α7 subunit does not aggravate the phenotype of laminin α2 chain-deficient mice.

Laminin-211 is a major constituent of the skeletal muscle basement membrane, exerting its biological functions by binding to cell surface receptors integrin α7β1 and dystroglycan (the latter is part of the dystrophin-glycoprotein complex). The importance of these molecules for normal muscle function is underscored by the fact that their respective deficiency leads to different forms of muscular dy