Filetype
Heart failure (HF) is a major contributor to global morbidity and mortality. While distinct clinical subtypes, defined by etiology and left ventricular ejection fraction, are well recognized, their genetic determinants remain inadequately understood. In this study, we report a genome-wide association study of HF and its subtypes in a sample of 1.9 million individuals. A total of 153,174 individual
Charged Higgs bosons produced either in top-quark decays or in association with a top quark, subsequently decaying via (Formula presented), are searched for in (Formula presented) of proton-proton collision data at (Formula presented) recorded with the ATLAS detector. Depending on whether the top quark is produced together with the (Formula presented) decays hadronically or semileptonically, the s
Inflammatory responses to acute stimuli are proposed to regulate sleep, but the relationship between chronic inflammation and habitual sleep duration is elusive. Here, we study this relation using genetically predicted level of chronic inflammation, indexed by CRP and IL6 signaling, and self-reported sleep duration. By Mendelian randomization analysis, we show that elevated CRP level within <10 mg
Top-quark pair production is observed in lead-lead ((Formula presented)) collisions at (Formula presented) at the Large Hadron Collider with the ATLAS detector. The data sample was recorded in 2015 and 2018, amounting to an integrated luminosity of (Formula presented). Events with exactly one electron and one muon and at least two jets are selected. Top-quark pair production is measured with an ob
Darknet framställs ofta som en digital värld präglad av avvikelse och kriminalitet – en plats där ”allt är tillåtet” och som därför anses kräva övervakning och kontroll. Trots detta är kryptoforum fortfarande relativt understuderade. Med utgångspunkt i tre års etnografiskt fältarbete ger denna avhandling nya insikter i de interna dynamikerna i en till stor del dold onlinegemenskap. Genom att kombiThe Darknet is often portrayed as an online realm marked by deviance and criminality – a space where “anything goes” and therefore requires policing. Yet its cryptoforums remain comparatively understudied. Drawing on three years of ethnographic fieldwork, this dissertation provides new insights into the internal dynamics of a largely hidden online community. Combining digital observations with 19
Infective endocarditis (IE) is most often caused by alpha-hemolytic streptococci or Staphylococcus aureus and is characterized by the presence of vegetations on the heart valves. Here we present a case of IE caused by Streptococcus pyogenes, a distinctly uncommon IE-pathogen, where no vegetations could be visualized on repeated echocardiography. Diagnosis was instead evident from septic embolizati
OBJECTIVES: Nociception monitoring during general anesthesia is evolving to improve intraoperative management and postoperative outcomes. While opioid-based anesthesia (OBA) remains widely used for its strong antinociceptive effects, concerns about opioid-induced adverse effects have fueled interest in opioid-free anesthesia (OFA) approaches. This study aimed to compare perioperative and postopera
In 2022 and 2023, the Large Hadron Collider produced approximately two billion hadronic interactions each second from bunches of protons that collide at a rate of 40 MHz. The ATLAS trigger system is used to reduce this rate to a few kHz for recording. Selections based on hadronic jets, their energy, and event topology reduce the rate to Ô(10) kHz while maintaining high efficiencies for important s
ALICE is a large experiment at the CERN Large Hadron Collider. Located 52 meters underground, its detectors are suitable to measure muons produced by cosmic-ray interactions in the atmosphere. In this paper, the studies of the cosmic muons registered by ALICE during Run 2 (2015–2018) are described. The analysis is limited to multimuon events defined as events with more than four detected muons (Nµ
INTRODUCTION: Health promotion in everyday settings is of great importance for both individual health and organizational sustainability. A settings-based approach emphasizes how social, physical, and organizational contexts shape the conditions for health. Central principles in health promotion are participation, empowerment, and person-centeredness, which emphasize the active role of the person o
This paper explores the rapid digitalization of the economy, focusing on the rise of platform and influencer economies, and examines their impact on place branding and clusters within rural regional development. Our study demonstrates how influencers in a rural industrial cluster become key figures in regional place branding by merging their digital identities with the natural resources they promo
The European spallation source (ESS) will be the world’s brightest neutron source and will open a new intensity frontier in particle physics. The HIBEAM collaboration aims to exploit the unique potential of the ESS with a dedicated ESS instrument for particle physics which offers world-leading capability in a number of areas. The HIBEAM program includes the first search in thirty years for free ne
Objectives: Sjögren's disease (SjD) and systemic lupus erythematosus (SLE) share genetic risk at the DDX6-CXCR5 locus (11q23.3). Identifying and functionally characterising shared SNPs spanning this locus can provide new insights into common genetic mechanisms of autoimmunity. Methods: Transdisease meta-analyses, fine-mapping, and bioinformatic analyses prioritised shared likely functional single
The years 2023 and 2024 were characterized by unprecedented warming across the globe, underscoring the urgency of climate action. Robust science advice for decision makers on subjects as complex as climate change requires deep cross- and interdisciplinary understanding. However, navigating the ever-expanding and diverse peer-reviewed literature on climate change is enormously challenging for indiv
This paper presents a measurement of jet-track correlations in photon-jet events, using 1.72 (Formula presented) of (Formula presented) data at (Formula presented) recorded with the ATLAS detector at the LHC. Events with energetic photon-jet pairs are selected, where the photon and jet are approximately back-to-back in azimuth. The angular correlation between jets and charged-particle tracks with
Importance: While clinical disease stages remained largely unchanged in the 2024 update of the Alzheimer disease (AD) criteria, tau-positron emission tomography (PET) was introduced as a core biomarker and its spatial extent was incorporated into the revised biological stages of the disease. It is important to consider both the clinical and the biological stages and understand their discrepancies.
During the 2015–2018 data-taking period, the Large Hadron Collider delivered proton-proton bunch crossings at a centre-of-mass energy of 13 TeV to the ATLAS experiment at a rate of roughly 30 MHz, where each bunch crossing contained an average of 34 independent inelastic proton-proton collisions. The ATLAS trigger system selected roughly 1 kHz of these bunch crossings to be recorded to disk. Offli
