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Serum thymidine kinase activity compared with CA 15-3 in locally advanced and metastatic breast cancer within a randomized trial

The primary objective was to estimate serum thymidine kinase 1 (TK1) activity, reflecting total body cell proliferation rate including cancer cell proliferation, in women with loco regional inoperable or metastatic breast cancer participating in a prospective and randomized study. Secondary objectives were to analyze TK1 in relation to progression-free survival (PFS), overall survival (OS), therap

Localization of embedded inclusions using detection of fluorescence: Feasibility study based on simulation data, LS-SVM modeling and EPO pre-processing

Fluorescence spectroscopy is a useful technique for tissue diagnostics and is also a promising tool in the characterization of embedded structures in tissue. The emitted fluorescence from an embedded inclusion, marked with a fluorescent compound, is affected by several factors as the light propagates through the medium to the tissue boundary, where the fluorescence light is detected. Tissue absorp

Upplevelsens poetik : slöjdseminariet på Nääs 1880–1940

This dissertation examines aspects of the experience of being a student at Nääs’ sloydseminar between 1880 and 1940 and what consequences it had for the participants. The experience was more or less consciously constructed by the charismatic leader Otto Salomon and after his death in 1907 the responsability of ”composing” the experience was put on Rurik Holm, pedagogical manager between 1913 and 1

Highly efficient enzymatic biodiesel production promoted by particle-induced emulsification.

At present, the conversion of oils to biodiesel is predominantly carried out using chemical catalysts. However, the corresponding lipase-catalysed process has important advantages, which include mild reaction conditions and the possibility of using cheap, low quality feedstocks with a high free fatty acid content. Further increases in the efficiency of the enzymatic process are desired to make it

Perception of occupational balance by people with mental illness: A new methodology.

Aims The aims were to (i) investigate initial construct validity of a tool for assessment of time allocation in occupational balance, and (ii) describe perceived occupational balance and its relationship with socio-demographics, well-being, and personal recovery among people with mental illness. Methods Satisfaction with Daily Occupations and Occupational Balance (SDO-OB) was administered to 226 p

Varför läsa litteratur – i Ryssland? Legitimeringar i ryska styrdokument

Artikeln utgår från Magnus Perssons studie av legitimeringar i svenska läroplaner i "Varför läsa litteratur" (2007) och gör motsvarande undersökning av de ryska läroplaner som publicerats sedan 1991. Legitimeringar har extraherats ur läroplaner från 1997 och 2004. Dessa delas sedan in i kategorierna individcentrerade, samhällscentrerade och litteraturcentrerade. Legitimeringarna fördelade sig förh

Toward Highlighting the Ultrafast Electron Transfer Dynamics at the Optically Dark Sites of Photocatalysts

Building a detailed understanding of the structure function relationship is a crucial step in the optimization of molecular photocatalysts employed in water splitting schemes. The optically dark nature of their active sites usually prevents a complete mapping of the photoinduced dynamics. In this work, transient X-ray absorption spectroscopy highlights the electronic and geometric changes that aff

Optimal Transmit Filters for ISI Channels under Channel Shortening Detection

We consider channels affected by intersymbol interference with reduced-complexity, mutual information optimized, channel-shortening detection. For such settings, we optimize the transmit filter, taking into consideration the reduced receiver complexity constraint. As figure of merit, we consider the achievable information rate of the entire system and with functional analysis, we establish a gener

Metabolic Factors Associated with Risk of Renal Cell Carcinoma

Previous studies have shown that obesity and hypertension are associated with increased risk of renal cell carcinoma (RCC), but less is known about the association to other metabolic factors. In the Metabolic Syndrome and Cancer project (Me-Can) data on body mass index (BMI, kg/m2), blood pressure, and circulating levels of glucose, cholesterol, and triglycerides were collected from 560,388 men an

Cancer of unknown primary (CUP): does cause of death and family history implicate hidden phenotypically changed primaries?

Cancer of unknown primary (CUP) is diagnosed at the metastatic stage. We aimed to identify hidden primary cancers in CUP patients by comparison with cancers in family members. We take use of the fact that the cause of death in CUP patients is often coded as the cancer in the organ of fatal metastasis. Forty-one thousand five hundred and twenty-three CUP patients were identified in the Swedish Fami

Laminar burning velocity of gasolines with addition of ethanol

The adiabatic laminar burning velocities of a commercial gasoline and of a model fuel (n-heptane, iso-octane, and toluene mixture) of close research octane number have been measured at 358 K. Non-stretched flames were stabilized on a perforated plate burner at 1 atm. The heat flux method was used to determine burning velocities under conditions for which the net heat loss of the flame is zero. Ver

Trötta mammors försvarare : familjevärderingar i Kerstin Thorvalls bilderböcker från 1970-talet

Kerstin Thorvall (1925–2010) is a Swedish author of books for children and young adults, as well as books for adults. In 1965, she wrote the article “Do all authors of children's books live in Tomtebolandet?” (“Bor alla barnboksförfattare i Tomtebolandet”, Expressen 1965) in which she claims that gender roles in Swedish children's literature, are depicted in an old and stereotypical fashion. She a

HLA Class I and Genetic Susceptibility to Type 1 Diabetes Results From the Type 1 Diabetes Genetics Consortium

OBJECTIVE-We report here genotyping data and type 1 diabetes association analyses for HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study. RESEARCH DESIGN AND METHODS-Complete eight-locus HLA genotyping data were generated. Expected patient class I (HLA-A, -B, and -C) allele frequencies were cal

Monocytes and macrophages, with a focus of Crohn's disease

Monocytes and macrophages are part of the body’s first line of defense, eliminating pathogens by phagocytosis or by releasing a broad array of inflammatory mediators, such as cytokines, chemokines and proteases. In humans, three subsets of monocytes are described with seemingly different functions. The classical (CD14++CD16-) monocytes, the intermediate (CD14++CD16+) monocytes and the non-classica