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The tumor suppressor protein p53 is an intrinsically disordered protein. Binding to DNA as a tetramer, the protein searches for mutations and prevents the replication of damaged DNA through apoptosis and growth arrest. Inactivation of p53 by mutation is recognized as a key step in the development of over 50 % of human cancers. The p53 protein family contains two additional proteins, p63 and p73. W
