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Unconditional two-locus nonparametric linkage analysis

We discuss different aspects of unconditional two-locus nonparametric linkage (NPL) analysis with special emphasis on gene-gene interaction. We interpret this as identical-by-descent (IBD) sharing correlation between two disease loci both having marginal effect. We relate this to the concept of two-locus NPL score functions, the possible importance of using a composite rather than a simple null hy

Risk of Birth Abnormalities in the Offspring of Men With a History of Cancer: A Cohort Study Using Danish and Swedish National Registries.

Background The potential mutagenic effects of cancer therapies and the growing number of young male cancer survivors have given rise to concern about the health of their offspring. Methods We identified all singleton children born alive in Denmark between 1994 and 2004 and in Sweden between 1994 and 2005 (n = 1 777 765). Of the 8670 children with a paternal history of cancer, 8162 were conceived n

Metabolic factors and the risk of pancreatic cancer: a prospective analysis of almost 580,000 men and women in the Metabolic Syndrome and Cancer Project.

BACKGROUND: The aim of this study was to investigate the association between factors in metabolic syndrome (MetS; single and combined) and the risk of pancreatic cancer. METHODS: The Metabolic Syndrome and Cancer Project is a pooled cohort containing data on body mass index, blood pressure, and blood levels of glucose, cholesterol, and triglycerides. During follow-up, 862 individuals were diagnose

Do Responsible Beverage Service Programs Reduce Breath Alcohol Concentration Among Patrons: A Five-Month Follow-up of a Randomized Controlled Trial.

Aims: To examine whether the decrease in the mean breath alcohol concentration (BrAC) and the rowdy social atmosphere reported after one month remained stable in the five-month assessment. Design: Randomized controlled trial. Setting: University bars. Participants: The five-month assessment was based on 596 students visiting student bars during ordinary pub evenings. Intervention: Bartenders (n =

Primary brain tumours and specific serum immunoglobulin E: a case-control study nested in the European Prospective Investigation into Cancer and Nutrition cohort.

To cite this article: Schlehofer B, Siegmund B, Linseisen J, Schüz J, Rohrmann S, Becker S, Michaud D, Melin B, Bas Bueno-de-Mesquita H, Peeters PHM, Vineis P, Tjonneland A, Olsen A, Overvad K, Romieu I, Boeing H, Aleksandrova K, Trichopoulou A, Bamia C, Lagiou P, Sacerdote C, Palli D, Panico S, Sieri S, Tumino R, Sanchez M-J, Rodriguez L, Dorronsoro M, Duell EJ, Chirlaque M-D, Barricarte A, Borgq

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Abstract in German Alles in allem eine Anthologie, die in Detailfragen durchaus aktuellste Forschungsergebnisse vorweisen kann, aber von einer annähernd vollständigen Forschungsübersicht zur Thematik „Musik und Nationalsozialismus“ weit entfernt ist, und auch nicht mit den in Monographien vorgelegten Forschungsergebnissen der Autorinnen und Autoren mithalten kann.