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Objectives: Phosphodiesterase 5 (PDE5) inhibitors improve smooth muscle relaxation and therefore are considered for pharmacotherapy of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Cyclic guanosine monophosphate (cGMP) -dependent protein kinase-1 (cGKI) has been identified as one of the downstream targets for cGMP. The aim of the present study was to evaluate, by mean

Popular Abstract in Swedish Kliniska och experimentella studier har visat att proteaser och deras inhibitorer deltar i mycket hög grad i luftvägarnas fysiologi och sjukdomsutveckling. Inflammatoriska celler, såsom neutrofiler, monocyter/makrofager, epitel- och mastceller, friger olika proteaser. Det är allmänt känt att ökad produktion eller aktivitet av proteaser eller inaktivering och minskad proProteases and their inhibitors are implicated in the physiology and pathology of the airways. Protease inhibitors include those produced locally, such as secretory leukocyte protease inhibitor (SLPI), and those produced mainly by the liver that can reach the airways via passive diffusion, such as alpha1-antitrypsin (AAT). SLPI is a significant component of the anti-neutrophil elastase shield in th

The formation of complexes in solutions containing positively charged polyions (polycations) and a variable amount of negatively charged polyions (polyanions) has been investigated by Monte Carlo simulations. The polyions were described as flexible chains of charged hard spheres interacting through a screened Coulomb potential. The systems were analyzed in terms of cluster compositions, structure

Popular Abstract in Swedish Under senare år har datorn kommit att bli ett vanligt inslag i förskolans dagliga verksamhet. Visioner och planer har formulerats, inte minst politiskt. Det har sedan varit upp till pedagogerna att organisera och genomföra datoranvändandet i den lokala förskolevardagen. Avhandlingens övergripande syfte är att studera datoranvändandets praktik i förskolan. Avsikten är däThe purpose of this thesis is to study the computer using practice within pre-school activity, or more specifically, to study aspects of meaning-making as afforded when the computer is in use in pre-school. In the study a socio-cultural perspective is used as the point of departure combined with an Ecological approach to visual perception and Positioning theory. Data was collected in three pre-sch

The social right of a secured income enough for subsistence in old age is an important aspect of social policy. Our objective has been to discuss public pension reform in New Zealand and Sweden. Through comparison we have revealed inherent forces fuelling as well as restricting pension reform. To better understand the political differences and counter forces an approach of “path dependency” derive

High-spin states of nuclei near doubly magic Ni-56 were studied with the reaction Si-28(Ar-36, xpynz alpha) at 136 MeV beam energy. The GAMMASPHERE array in conjunction with the 4 pi charged-particle detector array MICROBALL and neutron detectors were used to detect gamma rays in coincidence with evaporated light particles. The resulting extensive decay schemes of Fe-54, Co-54,Co-55, Ni-56,Ni-57,

This study reports the changes in number of breeding Starlings Sturnus vulgaris as recorded in seventeen areas distributed over all Sweden in 1981-2002. The number of breeding attempts declined by about fifty percent, consistent with the general decline observed in the Swedish Breeding Bird Survey. In no area was a long-term increase observed. There was no consistent geographical pattern; areas wi

I will describe the current status of the PYTHIA7 project to completely rewrite the 'Lund family' of event generators in C++. The PYTHIA7 program is a general platform for implementing event generator models and is not limited to the standard Lund programs (PYTHIA, JETSET, ARIADNE,...). Also the future C++ version of the HERWIG program will be implemented in the PYTHIA7 framework. The underlying f

Energy transfer in flow cytometry can occur when two fluorochromes are bound in close proximity (generally within 100 A) and the emission spectrum of one fluorochrome overlaps significantly with the excitation spectrum of the other. The latter criterium is fulfilled for the fluorochromes fluorescein isothiocyanate and propidium iodide and also the former when they, e.g., are used in bromodeoxyurid

We have previously described the evaluation of a cDNA microarray platform to identify and clone mutated barley (Hordeum vulgare L.) genes, using their transcriptionally defective mutant alleles (S. Zakhrabekova, C.G. Karmangara, D. von Wettstein, M. Hansson, A microarray approach for identification of mutated genes, Plant Physiol. Biochem. 40 (2002) 189-197). It was concluded that competitive hybr

Today most patients with CF reach adulthood and consequently marry and have children. Health care systems are lacking in knowledge of how these adults cope with the strain of having children. Eight patients were interviewed about their experiences of having children. The study was a qualitative descriptive study and the patients were interviewed with open questions regarding their experiences of p