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Coherent diffraction of single Rice Dwarf virus particles using hard X-rays at the Linac Coherent Light Source

Single particle diffractive imaging data from Rice Dwarf Virus (RDV) were recorded using the Coherent X-ray Imaging (CXI) instrument at the Linac Coherent Light Source (LCLS). RDV was chosen as it is a well-characterized model system, useful for proof-of-principle experiments, system optimization and algorithm development. RDV, an icosahedral virus of about 70 nm in diameter, was aerosolized and i

CFEL TapeDrive 2.0: a conveyor belt-based sample-delivery system for multi-dimensional serial crystallography

Serial crystallography (SX) at both X-ray free-electron lasers (XFELs) and synchrotrons offers the possibility to collect data at non-cryogenic temperature almost radiation damage free and enables time-resolved crystallography of irreversible reactions. The necessary steady delivery of new micron-sized crystals of biological macromolecules sets it apart from traditional single crystal macromolecul

Valuing drought impact mitigation on ecosystem services in a Mediterranean country

Drought is a complex natural hazard increasing in frequency, duration, and severity worldwide. Although droughts cause both market and non-market impacts, the latter suffers from a dearth of economic studies quantifying their magnitude. In this paper, we investigated how droughts affect selected ecosystem services expected to result in welfare losses in Spain. This study is aimed at quantifying an

Shock treatment in a cohort of Scandinavian intensive care units in 2014

BACKGROUND: Shock is common in intensive care units, and treatment includes fluids, vasopressor and/or inotropic drugs, guided by hemodynamic monitoring. The aim of this study was to identify current practice for treatment of shock in Scandinavian intensive care units.METHODS: Seven-day inception cohort study in 43 intensive care units in Scandinavia. Patients ≥ 15 years old receiving more than 4

Healthcare Professionals' Perceptions of Pre-, Peri-, and Postoperative Virtual Reality Immersion in Elderly Patients

Background/Objectives: There is a lack of research examining healthcare professionals' perspectives regarding the potential of non-pharmacological solutions such as immersive virtual reality (VR). The aim of this study was to investigate opportunities and challenges related to the application of immersive virtual reality (VR) technology in patients aged 65 and older undergoing surgery with regiona

The effects of virtual reality (VR) on clinical skills training in undergraduate radiography education : A systematic review

INTRODUCTION: The primary objective was to map the impact on confidence and performance on radiographic examinations among undergraduate radiography students utilizing virtual reality (VR). The secondary objective was to identify potential pitfalls to avoid in future VR implementation.METHODS: A systematic review was conducted, which included comprehensive search in nine databases. The software Co

Fragmented Power : The Reception of China's Foreign Policy Strategies in Sri Lanka

This dissertation proposes a theory concerning China’s “Fragmented Power” in its foreign policy pursuits by analyzing the reception of the “Belt and Road” Initiative in Sri Lanka. The initiative has sparked intense debates and counteractions on the global stage and has become synonymous with Xi Jinping’s assertive approach to foreign policy. However, many aspects of the initiative’s goals, impleme

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In this article I first follow Aristotle's and Plato's critique of materialism in an ancient context, then, in order to bring the topic into a more modern discussion, I follow Marx' dissertation on Democritos and Epicurus in its attempts to counter this critique from a materialist standpoint. Finally I conclude in reaffirming and nuancing Aristotle's critique, showing the limits of using matter as

Field-hybridization acoustic tweezers

Precise control of individual particles is crucial for biomedical diagnostics, i.e., single-cell analysis and drug delivery. Acoustic tweezers have shown promise as a precise method for capturing microscale objects, but the spatial selectivity remains challenging to achieve with traditional electroacoustic transducers. An alternative to traditional ultrasound generation is to use photoacoustic con

In Situ Detection of Programmed Cell Death Protein 1 and Programmed Death Ligand 1 Interactions as a Functional Predictor for Response to Immune Checkpoint Inhibition in NSCLC

Introduction: Immune checkpoint inhibitors (ICIs) have transformed lung cancer treatment, yet their effectiveness seem restricted to certain patient subsets. Current clinical stratification on the basis of programmed death ligand 1 (PD-L1) expression offers limited predictive value. Given the mechanism of action, directly detecting spatial programmed cell death protein 1 (PD1)–PD-L1 interactions m

Limits to collaboration in public transport : A typology

Collaboration between public and private partners is often seen as an important tool and is used by public authorities to handle many different problems in society, including public transport. In both research and practice, it is common to find exhortations to increase collaboration and suggestions on how to improve it and make it successful. However, in this chapter, we adopt a critical approach

Efficient Authentication Protocols from the Restricted Syndrome Decoding Problem

In this paper, we introduce an oracle version of the Restricted Syndrome Decoding Problem (RSDP) and propose novel authentication protocols based on the hardness of this problem. They follow the basic structure of the HB-family of authentication protocols and later improvements but demonstrate several advantages.An appropriate choice of multiplicative subgroup and ring structure gives rise to a ve

Gone With the Wind : The Structure and Function of the Dung Beetle Wind Compass

Prevailing winds carry seafarers across oceans and guide insects on their journeys. The South African, ball-rolling dung beetle Kheper lamarcki depends on a range of compass cues, including the azimuthal position of the sun and the directed airflow of wind to steer its plotted course. In this thesis, I set out to further our understanding for how these insects benefit from the directional componen

Entangled disasters : Relations and vulnerabilities in the transformation and dissolution of Kiruna and Malmberget

This chapter discusses the role of placed-based relational entanglements in disasters and argues that relations play an important part in shaping how disasters unfold. Exploring the case of mining induced displacement in Sweden’s Malmfälten region – where two cities, Kiruna and Malmberget, and several villages are being moved or razed to make way for expanding mines – the chapter demonstrates how This chapter explores the role of placed-based relational entanglements in disasters and argues that relations play an important part in shaping how disasters unfold. Exploring the case of mining-induced displacement in Sweden’s Malmfälten region—where two cities, Kiruna and Malmberget, and several villages are being moved or razed to make way for expanding mines—the chapter demonstrates how a str

Constraints and Costs : Essays in Corporate Finance

This thesis investigates how firms respond to internal and external financial pressures through four self-contained empirical studies in corporate finance. The first study explores how asset tangibility influences investment behaviour, finding that firms with more physical assets exhibit stronger sensitivity of investment to cash flow, indicating a deeper role for tangibility beyond traditional fi