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Don’t do it again! The Swedish experience with negative central bank rates in 2015-2019

Negative interest rates were once seen as impossible outside the realm of economic theory. However, recently several central banks have imposed such rates, with prominent economists supporting this move. This column investigates the actual effects of negative interest rates, taking evidence from the Swedish experience during 2015-2019. It is evident that the policy’s effect on the inflation rate w

Secondary Nucleation in Amyloid Formation

Research into Alzheimer's disease is still hampered by a lack of fundamental understanding of the underlying mechanisms. While the aggregation of the amyloid β peptide (Aβ) into amyloid fibrils is highly implicated as a key factor in the disease, the molecular nature of its involvement has proven complex and elusive. This thesis and the work herein is part of an ongoing effort to map out the aggre

Linking war, natural resources and public revenues: the case of the War of the Pacific (1879-1883)

We argue that wars over natural resources, even if they are limited in their military scope, can have long-term consequences on the level and composition of public revenues. Military success in a resource war may lead to the annexation of natural resource-rich areas from enemy combatants, which provides the winning coalition with valuable and easy-to-tax sources of income. This, however, might dis

Four-dimensional tomographic reconstruction by time domain decomposition

For classical tomography, it is essential that the sample does not change during the acquisition of one tomographic rotation. We derived and successfully implemented a tomographic reconstruction method, which relaxes this requirement of quasistatic samples. In the present paper, dynamic tomographic data sets are decomposed in the temporal domain by projecting to a lower dimensional subspace of bas

Anti-cruelty, violence and the law. Animal protection in early 19th-century England

In 1822 the Parliament of the United Kingdom passed The Cruel Treatment of Cattle Act, which today is considered to be an important forerunner to modern animal protection and anti-cruelty legislation. However, the new Enlightenment attitudes to animals stemmed from an overly anthropocentric perception of the natural world and the place of the human animal in it. At the heart of the movement agains

Optimising performance in clinical capsule endoscopy

Video capsule endoscopy (VCE), perfomed by ingesting a small vitamin-sized camera pill, was developed over a period of a couple of decades and –since its introduction in clinical practice at the dawn of the millennium– has become an essential tool in the diagnosis and management of small bowel (SB) diseases. At the same time, other fields such as minimally invasive diagnosis of other parts of the

Exercise and Peak Bone Mass

Purpose of review: The main goal of this narrative review is to assess whether physical activity (PA) influences peak bone mass and fracture risk. Recent findings: Several randomized controlled trials (RCT) show that short-term PA intervention programs in childhood improve the accrual of bone mineral. There are now also long-term controlled PA intervention studies demonstrating that both boys and

Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose

Acetaminophen is one of the most common over-the-counter pain medications used worldwide and is considered safe at therapeutic dose. However, intentional and unintentional overdose accounts for up to 70% of acute liver failure cases in the western world. Extensive research has demonstrated that the induction of oxidative stress and mitochondrial dysfunction are central to the development of acetam

TNFR1 is associated with short-term mortality in patients with diabetes and acute dyspnea seeking care at the emergency department

Background: Circulating levels of TNF alpha receptor 1 (TNFR1) and 2 (TNFR2) are associated with increased long-term mortality and impaired kidney function. Aim: To study association between circulating levels of TNFR1 and TNFR2 and short-term mortality in patients with diabetes and dyspnea. Population and methods: Patients aged ≥ 18 years seeking at emergency department (ED) during daytime on wee