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Traveling Water Waves - The Ebb and Flow of Two Centuries

This survey covers the mathematical theory of steady water waves with an emphasis on topics that are at the forefront of current research. These areas include: variational characterizations of traveling water waves; analytical and numerical studies of periodic waves with critical layers that may overhang; existence, nonexistence, and qualitative theory of solitary waves and fronts; traveling waves

P Wave Parameters and Indices : A Critical Appraisal of Clinical Utility, Challenges, and Future Research—A Consensus Document Endorsed by the International Society of Electrocardiology and the International Society for Holter and Noninvasive Electrocardiology

Atrial cardiomyopathy, characterized by abnormalities in atrial structure and function, is associated with increased risk of adverse cardiovascular and neurocognitive outcomes, independent of atrial fibrillation. There exists a critical unmet need for a clinical tool that is cost-effective, easy to use, and that can diagnose atrial cardiomyopathy. P wave parameters (PWPs) reflect underlying atrial

Preliminary Research : Application of Non-Invasive Measure of Cytochrome c Oxidase Redox States and Mitochondrial Function in a Porcine Model of Carbon Monoxide Poisoning

Introduction: Carbon monoxide (CO) is a colorless and odorless gas that is a leading cause of environmental poisoning in the USA with substantial mortality and morbidity. The mechanism of CO poisoning is complex and includes hypoxia, inflammation, and leukocyte sequestration in brain microvessel segments leading to increased reactive oxygen species. Another important pathway is the effects of CO o

Polygenic scores, diet quality, and type 2 diabetes risk : An observational study among 35,759 adults from 3 US cohorts

Background Bothgenetic and lifestyle factors contribute to the risk of type 2 diabetes, but the extent to which there is a synergistic effect of the 2 factors is unclear. The aim of this study was to examine the joint associations of genetic risk and diet quality with incident type 2 diabetes. Methods and findings We analyzed data from 35,759 men and women in the United States participating in the

A somatic mutation in moesin drives progression into acute myeloid leukemia

Acute myeloid leukemia (AML) arises when leukemia-initiating cells, defined by a primary genetic lesion, acquire subsequent molecular changes whose cumulative effects bypass tumor suppression. The changes that underlie AML pathogenesis not only provide insights into the biology of transformation but also reveal novel therapeutic opportunities. However, backtracking these events in transformed huma

To facilitate a fair bioeconomy transition, stronger regional-level linkages are needed

The great hopes in Brussels that a circular bioeconomy will help bridge the growing divide between urban and rural areas and allow the hinterlands to prosper from ‘green growth’ are addressed in this article, which reflects on insights from three Nordic case studies of brown, green and blue biomass use at different levels of technology readiness. A closer examination of the forward, backward, fisc

Paleohydrological history of Lake Allos (2200 m a.s.l) since 13 500 cal a bp in the Mediterranean Alps inferred from an ostracod δ18O record

This paper presents the first Lateglacial/Holocene (the last 13 500 cal a bp) ostracod δ18O record to infer hydroclimate variability in the Southern French Alps. Cytherissa lacustris (δ18Osp) shells extracted from the sediments of Lake Allos allowed a reconstruction of δ18Olake water (δ18Olw) except for the interval 5800–2800 cal a bp. The shape of the Younger Dryas (YD) clearly differed from reco

Reproductive hormone levels, androgen receptor CAG repeat length and their longitudinal relationships with decline in cognitive subdomains in men : The European Male Ageing Study.

Objective: It has been proposed that endogenous sex hormone levels may present a modifiable risk factor for cognitive decline. However, the evidence for effects of sex steroids on cognitive ageing is conflicting. We therefore investigated associations between endogenous hormone levels, androgen receptor CAG repeat length, and cognitive domains including visuoconstructional abilities, visual memory

Vieussens’ ring coronary collateral circulation : a natural bypass history

“Vieussens’ ring” or “arterial circle of Vieussens” is a crucial hetero-coronaric pathway, bridging proximal right coronary artery (RCA) and left anterior descending artery (LAD) when a hemodynami-cally stenosis is established in the either of the vessel. In detail such coronary collateral circulation is usually supplied by branches of the conus artery. We present a case of a 62-year-old man who w

Observation of a linked-loop quantum state in a topological magnet

Quantum phases can be classified by topological invariants, which take on discrete values capturing global information about the quantum state1–13. Over the past decades, these invariants have come to play a central role in describing matter, providing the foundation for understanding superfluids5, magnets6,7, the quantum Hall effect3,8, topological insulators9,10, Weyl semimetals11–13 and other p

Influence of Age and Genetic Background on Ethanol Intake and Behavioral Response Following Ethanol Consumption and During Abstinence in a Model of Alcohol Abuse

Genetic background and age at first exposure have been identified as critical variables that contribute to individual vulnerability to drug addiction. Evidence shows that genetic factors may account for 40–70% of the variance in liability to addiction. Alcohol consumption by young people, especially in the form of binge-drinking, is becoming an alarming phenomenon predictive of future problems wit

Spin diffusion transfer difference (SDTD) NMR : An advanced method for the characterisation of water structuration within particle networks

Hypothesis: The classical STD NMR protocol to monitor solvent interactions in gels is strongly dependent on gelator and solvent concentrations and does not report on the degree of structuration of the solvent at the particle/solvent interface. We hypothesised that, for suspensions of large gelator particles, solvent structuration could be characterised by STD NMR when taking into account the parti

Structural evolution of iron forming iron oxide in a deep eutectic-solvothermal reaction

Deep eutectic solvents (DES) and their hydrated mixtures are used for solvothermal routes towards greener functional nanomaterials. Here we present the first static structural and in situ studies of the formation of iron oxide (hematite) nanoparticles in a DES of choline chloride : urea where xurea = 0.67 (aka. reline) as an exemplar solvothermal reaction, and observe the effects of water on the r

Microstructural, Thermal, Crystallization, and Water Absorption Properties of Films Prepared from Never-Dried and Freeze-Dried Cellulose Nanocrystals

In this paper, the microstructural, optical, thermal, crystallization, and water absorption properties of films prepared from never-dried (ND) and freeze-dried (FD) cellulose nanocrystals (CNCs) are reported. Morphology of the ND CNCs reveals a needle-like structure, while after freeze-drying, they show a flake-like morphology. Microstructural analysis of ND and FD CNCs are further studied via sma

Interactions of water and amphiphiles with deep eutectic solvent nanostructures

Deep eutectic solvents (DES) are extensively hydrogen-bonded eutectic mixtures with low melting points. The presence of H-bonding makes them highly susceptible to interactions with water and also allows them to support amphiphile self-assembly, both for surfactants and biological lipids. Water disrupts the DES nework through intermolecular H-bonding, leading to changes in physicochemical propertie

Composite Hydrogel Spheroids Based on Cellulose Nanofibrils and Nanofibrous Chiral Coordination Polymer by Green Synthesis

Cellulose-based hydrogels are promising sustainable materials for a variety of applications, including tissue engineering, water treatment, and drug delivery. However, the tailoring of diverse properties by efficient green chemistry methods is an ongoing challenge. Here, composite hydrogels of consistent spheroidal structure, incorporating TEMPO-oxidized cellulose nanofibrils and nanofibrous chira

Core-Shell Spheroidal Hydrogels Produced via Charge-Driven Interfacial Complexation

Through charge-driven interfacial complexation, we produced millimeter-sized spheroidal hydrogels (SH) with a core-shell structure allowing long-term stability in aqueous media. The SH were fabricated by extruding, dropwise, a cationic cellulose nanofibril (CCNF) dispersion into an oppositely charged poly(acrylic acid) (PAA) bath. The SH have a solid-like CCNF-PAA shell, acting as a semipermeable

Small angle X-ray scattering from MCM-41 and its synthesis gels : optimisation of the synthesis parameters

We have found optimised conditions for alkaline synthesis of the large pore molecular sieve, MCM-41, by determining small angle X-ray scattering and adsorption isotherms from materials at various stages of the preparation. The presence of highly curved surfaces, sealed structures, and quasicrystalline hexagonal products coexisting with true MCM-41 are all detected by transmission electron microsco