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Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic-Uremic Syndrome

Background Atypical hemolytic-uremic syndrome is a genetic, life-threatening, chronic disease of complement-mediated thrombotic microangiopathy. Plasma exchange or infusion may transiently maintain normal levels of hematologic measures but does not treat the underlying systemic disease. Methods We conducted two prospective phase 2 trials in which patients with atypical hemolytic-uremic syndrome wh

Infection dynamics of the tick-borne pathogen 'Candidatus Neoehrlichia mikurensis' and co-infections with Borrelia afzelii in bank voles in Southern Sweden.

The tick-borne bacterium 'Candidatus Neoehrlichia mikurensis' has recently been recognized as a human pathogen. Together with Borrelia afzelii, it is one of the most common pathogens found in the tick Ixodes ricinus. Here, we compared the epidemiology of 'Candidatus N. mikurensis' and B. afzelii by longitudinal sampling from May to September in one of their most abundant vertebrate hosts, the bank

Warm climate isotopic simulations: what do we learn about interglacial signals in Greenland ice cores?

Measurements of Last Interglacial stable water isotopes in ice cores show that central Greenland delta O-18 increased by at least 3 parts per thousand compared to present day. Attempting to quantify the Greenland interglacial temperature change from these ice core measurements rests on our ability to interpret the stable water isotope content of Greenland snow. Current orbitally driven interglacia

Methods for individualising factor VIII dosing in prophylaxis

Haemophilia A is a sex-linked disorder characterised chiefly by recurrent, spontaneous joint and muscle bleedings resulting from deficiency of factor VIII (FVIII). Recurrent joint bleeds result in haemophilic arthropathy. Unless treated with factor replacement therapy, many patients with severe haemophilia become disabled. The first clinical evidence favouring prophylaxis originated from the studi

Can One Distinguish Quantum Trees From The Boundary?

Schrodinger operators on metric trees are considered. It is proven that for certain matching conditions the Titchmarsh-Weyl matrix function does not determine the underlying metric tree; i.e. there exist quantum trees with equal Titchmarsh-Weyl functions. The constructed trees form one-parameter families of isospectral and isoscattering graphs.

Assessing spider diversity on the forest floor: expert knowledge beats systematic design

The design of sampling schemes affects the results of biodiversity inventories. As an approach for quantifying the implications of such effects, we compared data on spider communities sampled in a beech-dominated forest floor habitat by 1) a regular grid of pitfall traps (systematic design) and 2) an expert-based distribution of traps (stratified design). We tested whether the two designs would le

Upgrading to lead firm position via international acquisition: learning from the global biomass power plant industry.

This article examines the case of a Chinese firm that has upgraded to lead firm position in the global biomass power plant industry mainly through acquisitions of technological frontier firms in Denmark. Sustaining the lead firm position was, however, challenged by difficulties in developing innovative capability. Drawing on the literature on (i) firm-level technological capability and (ii) knowle

Systematics and conservation genetics of Dactylorhiza majalis ssp elatior (Orchidaceae) on Gotland

A tall allotetraploid member of the Dactylorhiza incarnata/maculata complex with unspotted leaves and large pinkish flowers from the island of Gotland in the Baltic was examined for molecular variation patterns at five nuclear microsatellite loci, nuclear ITS and in plastid haplotypes. The allotetraploid was well separated from allopatric allotetraploids of similar appearance, including the wester

Evaluating the Effect of Biofilm Thickness on Nitrification in Moving Bed Biofilm Reactors.

This study evaluates the effect of biofilm thickness on the nitrifying activity in moving bed biofilm reactors (MBBRs) in a controlled environment. In-depth understanding of biofilm properties in MBBRs and their effect on the overall treatment efficiency compose the key to optimizing process stability and efficiency. However, evaluating biofilm properties in continuously operated MBBRs can be extr

A method for rapid screening of ketone biotransformations: Detection of whole cell Baeyer-Villiger monooxygenase activity.

A method for screening of ketone biotransformations was developed and applied to the identification of Baeyer-Villiger monooxygenase (BVMO) activity. The method was based on the formation of a purple coloured product on reaction between an enolizable ketone and 3,5-dinitrobenzoic acid in an alkaline solution. Absorbance of the colour decreased with the size of the cycloketone ring. Stoichiometric

Functional integration of new hippocampal neurons following insults to the adult brain is determined by characteristics of pathological environment.

We have previously shown that following severe brain insults, chronic inflammation induced by lipopolysaccharide (LPS) injection, and status epilepticus, new dentate granule cells exhibit changes of excitatory and inhibitory synaptic drive indicating that they may mitigate the abnormal brain function. Major inflammatory changes in the environment encountering the new neurons were a common feature

Bystander behavior in bullying situations: Empathy, moral disengagement and defender self-efficacy

The aim of the present study was to investigate how basic moral sensitivity in bullying, moral disengagement in bullying and defender self-efficacy were related to different bystander behaviors in bullying. Therefore, we examined pathways that linked students’ basic moral sensitivity, moral disengagement, and defender self-efficacy to different bystander behaviors in bullying situations. Three hun