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Transformative neuropathology is redefining human brain research by integrating foundational descriptive pathology with advanced methodologies. These approaches, spanning multi-omics studies and machine learning applications, will drive discovery for the identification of biomarkers, therapeutic targets, and complex disease patterns through comprehensive analyses of postmortem human brain tissue.
The work of stage actors has long been used as a simile for every day role playing, generating theoretical concepts to describe how people work to pre-sent themselves in general and how they manage their emotions in particular. Building on this tradition, this article analyses professional stage actors’ deliberate emotion management as an embodied professionalisation process, focusing the relationThe work of stage actors has long been used as a simile for every day role playing, generating theoretical concepts to describe how people work to pre-sent themselves in general and how they manage their emotions in particular. Building on this tradition, this article analyses professional stage actors’ deliberate emotion management as an embodied professionalisation process, focusing the relation
The dominant image of judicial authority is emotional detachment; however, judicial work involves emotion. This presents a challenge for researchers to investigate emotions where they are disavowed. Two projects, one in Australia and another in Sweden, use multiple sociological research methods to study judicial experience, expression, and management of emotion. In both projects, observational resThe dominant image of judicial authority is emotional detachment; however, judicial work involves emotion. This presents a challenge for researchers to investigate emotions where they are disavowed. Two projects, one in Australia and another in Sweden, use multiple sociological research methods to study judicial experience, expression, and management of emotion. In both projects, observational res
The role of emotions in qualitative research receives increasing attention. We argue for an active rather than a reactive approach towards emotions to improve the quality of research; emotions are a vital source of information and researchers use emotions strategically. Analysing the emotion work of researchers in the process of gaining, securing and maintaining access to the Swedish judiciary, weThe role of emotions in qualitative research receives increasing attention. We argue for an activerather than a reactive approach towards emotions to improve the quality of research; emotionsare a vital source of information and researchers use emotions strategically. Analysing the emotionwork of researchers in the process of gaining, securing and maintaining access to the Swedishjudiciary, we pro
Detailed analysis of two theatre productions shows that the conceptof bounded emotionality can be used to tease out aspects of emotionmanagement that would not otherwise have been detectable. Non-instrumentalways to manage emotions – to facilitate emotion work – are used in situationswhere the goal is to produce quality performances, not to promote well-beingas such. The rehearsal period consists Detailed analysis of two theatre productions shows that the conceptof bounded emotionality can be used to tease out aspects of emotionmanagement that would not otherwise have been detectable. Non-instrumentalways to manage emotions – to facilitate emotion work – are used in situationswhere the goal is to produce quality performances, not to promote well-beingas such. The rehearsal period consists
This study focuses on developing a consumer-centric Environmental, Social, Governance (ESG) evaluation scale for the aviation industry, highlighting the growing importance of corporate sustainability actions from a consumer perspective. With the aviation sector being significantly impacted by sustainability challenges, the need for a strategic approach to leverage ESG management for competitive ad
This thesis concerns localisation, shape reconstruction and pose estimation from monocular images. While multiple cameras allows for triangulation to capture depth in scenes, monocular settings require some of relative features, reasonable real-world assumptions, regularisation, Machine Learning (ML) or a combination of these. The accompanying articles to this compilation thesis treats several top
BACKGROUND: The global prevalence of dementia is rapidly expanding and is expected to triple by 2050. Approximately 45 % of dementia cases are estimated to be attributable to potentially modifiable risk factors. Identifying how these factors contribute to specific brain pathologies may improve strategies to reduce dementia incidence.OBJECTIVES, DESIGN, SETTING: The aim of this study was to identif
The study aims to quantitatively assess the availability of various infrastructures for doing business and identify the main barriers in the infrastructure industry that hinder the ease of doing business and investment development in regions of Kazakhstan. The authors assessed infrastructure accessibility in Kazakhstan’s regions based on an SME managers’ survey. They developed an index of infrastr
Spontaneous (non-traumatic) intracerebral haemorrhage (ICH) affects ~3.4 million people worldwide each year, causing ~2.8 million deaths. Many randomised controlled trials and high-quality observational studies have added to the evidence base for the management of people with ICH since the last European Stroke Organisation (ESO) guidelines for the management of spontaneous ICH were published in 20
This contribution aims to identify and clarify emotional aspects of conducting observation studies. The researcher, in most cases, does not want to interfere with or influence the phenomenon under observation, but uses her/himself as a tool to collect material. Even if the observer does not participate verbally, s/he can be emotionally participative using her/his emotions as a methodological tool,
Probabilistic numerical solvers for ordinary differential equations (ODEs) treat the numerical simulation of dynamical systems as problems of Bayesian state estimation. Aside from producing posterior distributions over ODE solutions and thereby quantifying the numerical approximation error of the method itself, one less-often noted advantage of this formalism is the algorithmic flexibility gained
This chapter explores performances of emotion regulation through a dramaturgical lens, focusing on occupations with high performative demands. While reviewing research and theorizing on performance, we point to key intersections between sociological studies on emotion management and psychological studies on emotion regulation. First, we focus on the scaffolding of performance, how the script and t
With the rapid development of blood biomarkers (BBMs) related to amyloid-β (Aβ) pathology in Alzheimer's disease (AD), the question arises whether these can replace the accepted reference standard, positron emission tomography (PET), for assessing Aβ burden. BBMs can differentiate Aβ status reliably in cognitively impaired patients, but two-threshold strategies to further improve their performance
