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Background: Bisphosphonates have previously been shown to increase the density of impacted graft bone. In the present study we hypothesise that bisphosphonates also reduce early stem subsidence. We examined the effect of locally applied bisphosphonate to allografts on prosthetic micromotion and bone density in femoral stem revision with impaction grafting. Methods: 37 patients were randomised to e
Objective: Atherosclerosis is characterized by accumulation of lipids, cells and extracellular matrix (ECM) proteins in the arterial wall. Collagen type I (COL1), a component of the arterial ECM, is cleaved by matrix metalloproteinases (MMPs) and known to be remodelled in atherosclerosis. We explored whether the MMP-mediated COL1 biomarker, C1M, was associated with cardiovascular events, cardiovas
The semi-quantitative estimate standardised uptake value ratios (SUVR) correlate well with specific binding of the tracer expressed as distribution volume ratios (DVR) for the tau positron emission tomography tracer [18F]AV-1451 uptake and are therefore widely used as proxy for tracer binding. With regard to tracer kinetic modelling, there exists a time point when SUVR deviates minimally from DVR,
U–Pb zircon dates of metagabbroic rocks, such as eclogite, mafic granulite, and garnet amphibolite, are used to constrain the timing of tectonometamorphic evolution in orogens worldwide. For such interpretation, however, it is imperative to define at which stage of the P–T evolution that zircon crystallization took place: the prograde, peak, or retrograde stage. In order to accurately interpret me
We consider Hilbert spaces of analytic functions in the disk with a normalized reproducing kernel and such that the backward shift f(z)↦[Formula presented] is a contraction on the space. We present a model for this operator and use it to prove the surprising result that functions which extend continuously to the closure of the disk are dense in the space. This has several applications, for example
This article explores the financial dilemma from a household level perspective of paying for primary education in Tanzania. In 2001, the primary education fee was abolished in a serious attempt to achieve free universal primary education. By eliminating what was perceived as the main obstacle for reaching education for all, the enrollment rates were expected to increase. However, the schools thems
A new proof of the equivalence of the Taut String Algorithm and the one-dimensional Rudin–Osher–Fatemi model is presented. Based on duality and the projection theorem in Hilbert space, the proof is strictly elementary. Existence and uniqueness of solutions (in the continuous case) to both denoising models follow as by-products. The standard convergence properties of the denoised signal, as the reg
Cancer cells sustain their metabolic needs through nutrients and oxygen supplied by the bloodstream. The requirement for tumor angiogenesis has been therapeutically exploited in the clinical setting mainly by means of inhibition of the vascular endothelial growth factor family of ligands and receptors. Despite promising results in preclinical models, the benefits for patients proved to be limited.
Lubna Hawwa och Andreas Mattsson om religiös extremism och förtryck på Maldiverna
This work represents a critical re-examination of the application of dynamic light scattering (DLS)–based tracer particle microrheology to measure the zero shear viscosity of aqueous solutions of different proteins up to very high concentrations. It is demonstrated that a combination of surface-functionalized tracer particles, the use of the so-called 3D-DLS technique, and carefully chosen paramet
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Changes to agricultural systems in Sub-Saharan Africa are subject to a wide range of drivers, often resulting in rapid and nonlinear dynamics. Such dynamics are however rarely recognized in studies of trends and drivers, which usually rely on assumptions of gradual progressions, and often using highly aggregated data. This paper addresses this lack of recognition and understanding of nonlinear pro
Quinolines, indolizines, and coumarins are well known structural elements in many biologically active molecules. In this report, we have developed straightforward methods to incorporate quinoline, indolizine, and coumarin structures into galactoside derivatives under robust reaction conditions for the discovery of glycomimetic inhibitors of the galectin family of proteins that are involved in immu
Introduction: The demographic changes with population ageing and a rapidly growing share of very old peoplewill put an increasing pressure on the health and social care system. In order to both restrict early retirement and force people to extend their working life reforms are changing pension systems in many European countries. Besides that older people have to extend their working life it is imp
The report summarises a small case study in which two research groups were interviewed and observed as they were planning, conducting and analysing experiments at MAX IV Laboratory.The aim of the study was to identify the current research data management practices of the scientists, and to connect this to how these practices are supported by MAX IV.The report summarises a small case study in which two research groups were interviewed and observed as they were planning, conducting and analysing experiments at MAX IV Laboratory.The aim of the study was to identify the current research data management practices of the scientists, and to connect this to how these practices are supported by MAX IV.
Institutions for prevention and resolution of industrial conflicts were introduced all over the world in the early twentieth century. We use a new dataset of geocoded strikes and lockouts to analyze the impact of mediation on conflict outcomes in Sweden for the period 1907–1927. Causality is identified by using the distance from the mediator’s place of residence to the conflict as an instrument. D
