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Bakgrunn.I Norge blir det hvert år analysert hundretusener av urinprøver for å påvise inntak av rusmidler og legemidler med ruspotensial. Ved Avdeling for klinisk farmakologi ved St. Olavs hospital analyseres årlig rundt 60 000 urinprøver for rusmidler og legemidler med ruspotensial. Vi ønsket å finne ut om vårt standard analysepanel avdekker de fleste.Materiale og metode.Alle urinprøver mottatt i
We present a systematic study on the interaction potential of lamotrigine, with focus on psychoactive drugs. A review of routine serum concentration measurements of lamotrigine performed in our laboratory yielded a total of 1733 serum samples from 829 patients (530 women, 299 men) suitable for statistical analysis. Main results for the whole study population were (median; interquartile range in pa
Purpose: To study the interaction between lamotrigine (LTG) and hormonal contraception. Methods: LTG serum concentrations of female patients using either no hormonal contraception (n = 18), an ethinyl estradiol (EE)-containing (n = 11), or a progestogen (PG)-only-containing compound (n = 16) were analyzed. Patients were recruited prospectively, and blood samples were drawn during drug fasting and
Objective: To investigate the impact of age and co-treatment with other drugs on the serum concentrations of lamotrigine in children and adolescents. Methods: A review of routine serum concentration measurements of lamotrigine performed in our laboratory yielded a total of 744 serum samples from 296 subjects (110 males, 186 females, age: 2-19 years) suitable for statistical analysis. The primary o
Efficient prevention of adverse drug reactions (ADRs) requires knowledge about their severity and pharmacological mechanisms and is dependent on reliable data on their frequencies and possible risk factors. The study was conducted to investigate the prescribers' experience and understanding of the ADRs of psychotropic drugs, and their attitude towards reporting these. In a questionnaire, physician
OBJECTIVES: To measure the serum concentrations of lamotrigine throughout a complete menstrual cycle. METHODS: Serum concentrations of lamotrigine, estradiol, and progestogen throughout a menstrual cycle were measured in 2 young women not using hormonal contraception. RESULTS AND CONCLUSIONS: The physiological hormonal fluctuations during an ovulatory cycle were not associated with clinically rele
Purpose: To investigate changes in levetiracetam (LEV) serum concentration/dose ratio (C/D-ratio) in relation to pregnancy. Methods: Altogether 21 consecutive pregnancies in 20 women with epilepsy receiving LEV during gestation were studied retrospectively. The main target variable was the C/D-ratio before and during pregnancy, and in the post partum period. Secondary target variables were changes
Background. In some situations, and particularly when intoxications are suspected, it would be advantageous if medicines and drugs of abuse could be swiftly detected in serum or urine. Material and methods. The Department of Clinical Pharmacology at St. Olav University Hospital has since 2004 been developing a comprehensive toxicology service (at all hours 7-days/week) for immediate quantitative a
The main concerns associated with epilepsy during pregnancy consist of maternal and fetal risks from uncontrolled seizures, and harmful effects of the treatment on the development of the offspring. Although seizure control is maintained in the majority, worsening occurs in a fraction of childbearing women with epilepsy. As multiple factors associated with pregnancy may have a negative impact on ep
Purpose: To study the impact of pregnancy on the serum concentration/dose ratio (C/D-ratio) of topiramate (TPM). Methods: Twelve women with epilepsy using TPM during pregnancy, and 15 pregnancies were studied. The main target variable was the C/D-ratio at baseline and during pregnancy. Additional variables were changes in TPM dose, concomitant use of other antiepileptic drugs, seizure frequency, a
After common belief the impairment of nerve conduction seen with multiple sclerosis has to do with uncovering of internodal potassium channels. Therefore, suitable potassium channel blockers like 5-methoxypsoralen can alleviate functional deficits due to multiple sclerosis. This has been demonstrated by single tests under well-defined laboratory conditions and by further clinical single trials. Wi
The effects of the medicinal plant rue (Ruta graveolens L.) on MS-related visual-field defects was tested. In five of nine patients the scotomata were reduced by a single dose of an aqueous extract of 3 g of the drug; the effect was reversible, appearing after only about two hours and lasting for one to two days. There was no detectable action in four patients. In no case were undesirable side eff
The effects of myoglobin on renal microcirculation were studied in anesthetized rats subjected to hemorrhagic hypotension. Capillary flow distribution was determined by allowing two dyes to circulate for 3 and 1 min, respectively, freezing the left kidney and quantifying the dye distribution in histological sections by analyzing the distances of regularly spaced test points to the next dye-labeled
Background. The debate about increased welfare and health service costs is well-known in relation to the growing ageing population. Over the past thirty years, ageing in place has been the guiding principle for policies concerning older people and housing in Sweden and other Western countries. Sweden is among the countries in the European Union and internationally whose populations have the longes
