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Background: Phylogeny construction can help to reveal evolutionary relatedness among molecular sequences. The spike (S) gene of SARS-CoV-2 is the subject of an immune selective pressure which increases the variability in such region. This study aimed to identify mutations in the S gene among SARS-CoV-2 sequences collected in the Middle East and North Africa (MENA), focusing on the D614G mutation,
The occurrence of a series of thin but persistent early Cambrian (Cambrian Age 4) brachiopod shell concentrations extending along a transect of some 150 km in NE Greenland, indicates the ability of the group to form widespread, skeletal pavements very early in the history of the phylum, its gregarious behaviour and ability to harness available nutrients. These extensive shell pavements within the
Objective: The Attempted Suicide Short Intervention Program (ASSIP) was adapted for hospital delivery and to address substance use problems as well as evaluated for feasibility, acceptability, and therapist fidelity in a series of preparatory steps (n = 28) and in a pilot randomized controlled trial, RCT (n = 34). Method: In the RCT, patients with suicide attempts and substance use problem(s) with
Plastic extension of Ezkil by Ramon Lazkano. Brass sheets, wood sheet, mosquito net, speakers, amplifier + 3 microphones and a guitarist when “needed”.
To a large extent functional diversity in cells is achieved by the expansion of molecular complexity beyond that of the coding genome. Various processes create multiple distinct but related proteins per coding gene – so-called proteoforms – that expand the functional capacity of a cell. Evaluating proteoforms from classical bottom-up proteomics datasets, where peptides instead of intact proteoform
The Mediterranean basin is a hotspot of biodiversity, fuelled by climatic oscillation and geological change over the past 20 million years. Wall lizards of the genus Podarcis are among the most abundant, diverse, and conspicuous Mediterranean fauna. Here, we unravel the remarkably entangled evolutionary history of wall lizards by sequencing genomes of 34 major lineages covering 26 species. We demo
Plastic extension of Breviario de espejismos by Elena Mendoza. Glued paper, two speakers, amplifier, video, tablet, LED light, photographic montage, four metal supports, fishing line, metal strings, two wooden boxes, two mixed metal-wooden supports.
Bright and efficient blue emission is key to further development of metal halide perovskite light-emitting diodes. Although modifying bromide/chloride composition is straightforward to achieve blue emission, practical implementation of this strategy has been challenging due to poor colour stability and severe photoluminescence quenching. Both detrimental effects become increasingly prominent in pe
Iron deposition is present in main lesion areas in the brains of patients with Parkinson’s disease (PD) and an abnormal iron content may be associated with dopaminergic neuronal cytotoxicity and degeneration in the substantia nigra of the midbrain. However, the cause of iron deposition and its role in the pathological process of PD are unclear. In the present study, we investigated the effects of
To clarify the structure of genetic risks for 11 major psychiatric disorders, we calculated, from morbidity risks for disorders in 1st–5th degree relatives controlling for cohabitation effects, in the Swedish population born between 1932 and 1995 (n = 5,830,014), the family genetic risk scores (FGRS) for major depression (MD), anxiety disorders (AD), obsessive-compulsive disorder (OCD), bipolar di
Background: The aim of this study was to identify factors predicting outcome in patients with mitochondrial disease admitted to pediatric intensive care units (PICU). Methods: Retrospective study of 2434 patients (age <21 years) admitted to a PICU from 1 January 2006 through 31 March 2016 and captured in the Virtual Pediatric Systems database with ICD9 diagnosis 277.87, disorders of mitochondrial
Mantle cell lymphoma (MCL) is characterized by marked differences in outcome, emphasizing the need for strong prognostic biomarkers. Here, we explore expression patterns and prognostic relevance of circular RNAs (circRNAs), a group of endogenous non-coding RNA molecules, in MCL. We profiled the circRNA expression landscape using RNA-sequencing and explored the prognostic potential of 40 abundant c
PCR of TCR/Ig gene rearrangements is considered the method of choice for minimal residual disease (MRD) quantification in BCP-ALL, but flow cytometry analysis of leukemia-associated immunophenotypes (FCM-MRD) is faster and biologically more informative. FCM-MRD performed in 18 laboratories across seven countries was used for risk stratification of 1487 patients with BCP-ALL enrolled in the NOPHO A
Bitumen är den tyngsta produkten från raffinaderier. Den är användbar som bindemedel för olika ytbeläggningar som t.ex. asfalt på vägar, takpapp m.m. Företag Nordic Waterproofing tillverkar takpapp i Höganäs och använder bitumen som en av de viktigaste råvarorna i processen. Ett förnyelsebart samhälle är dagens fokusmål för alla, inte bara enskilda personer, utan hela landet och hela planet måste Nordic Waterproofing is one of the largest roofing felt producers in Europe. One of the production facility is located in Höganäs (Sweden), which is specialized in roofing felt that are suitable for the nordic climate. Bitumen is a central component of roofing felt manufacturing that contribute several properties to the product. Due to the importance of bitumen, Nordic Waterproofing finds an addit
Hur medicinen ser på och benämner intersexpersoner, d.v.s. personer som föds med kroppsliga variationer gällande könskaraktäristika, inklusive hormonella och/eller anatomiska och kromosomala variationer, vilka inte avläses som typiskt manliga eller kvinnliga får direkta konsekvenser för dessa människor i form av kirurgiska ingrepp och andra behandlingar. Ofta sker ingreppen på barn som inte har mö
Datoranalys av cellernas eget flagg-system kan bidra till forskningen kring patient-anpassade cancerbehandlingar Tänk dig att du zoomar in på cellytan utav dina celler. Något som du kommer lägga märke till är uppradade molekyler med små utstickande protein-stumpar (peptider). De står nästan som flaggstänger med viftande flaggor i olika former. Dessa ”flaggstänger” kallas för MHC molekyler och de The exceptionally polymorphic Human Leukocyte Antigen (HLA) genes play a crucial role in the immune system’s interplay with non-immune cells. Certain HLA alleles are known to have a strong disease correlation. There is a growing interest, within several research fields, in determining (typing) HLA alleles at higher resolution than what is possible today using standard laboratory methods. Within th
SLAP2: A potential new strategy in fighting cancer Among more than 20,000 genes in humans, about 2% of genes encode a class of proteins referred to as kinases. A kinase is a protein, which transfers phosphate groups to proteins called substrate proteins. This process is named phosphorylation and almost all cellular behaviors are controlled by protein phosphorylation. Kinases mainly phosphorylate
