Filetype
Facing the limitations of current wildfire management practices, increasing attention has been paid to indigenous wildfire practices that use fire for ground fuel reduction. This study investigated the cooperation and association between indigenous and non-indigenous peoples for current wildfire management, with a focus on prescribed burning, to provide a comprehensive review of activities. Throug
To read, to grasp, to copy, to erase, to revive, to modulate, to distort, to re-create , to saturate, to reproduce, to grow, to devour, to eat, to multiply, to protect, the essence , the fragments, a story, materiality, to unbuild , to enhance, to (im)materialise, to shape, to expand, to explore. We encounter today a lack of identity in architecture, no style, no language, pure impulsive and sen
This master’s thesis examines the challenges and changes faced by voluntary local sections of the German Federal Agency for Technical Relief (THW). The study aims to identify key factors influencing volunteer recruitment, training, and retention within these sections, particularly focusing on the impact of societal changes, workload, training limitations, and administrative burdens on the voluntee
This thesis analyzes lived experiences from former juku students as well as promotional material produced by three shingakujuku (Nichinōken, Yotsuya Ōtsuka, Sapix) aimed at the private junior high school entrance examinations in Japan. The research questions aims to investigate the framing of the future and outcome of attending juku as well as how former students reflect on their own experience an
Cancer is a disease condition where the cells proliferate uncontrollably leading to organ failure, metabolic collapse (cachexia), chronic inflammation combined with immune dysregulation, and many more. Out of the most prevailing cancers, breast cancer ranks second in the world of which 75% are diagnosed with hormone-dependent breast cancers. Bile Salt Stimulated Lipase(BSSL), a lipolytic enzyme se
This thesis seeks to answer the question of whether obligations to primary pandemic prevention and bio-risk management can be derived from the human right to health. The definition of the right to health in Article 12 of the International Covenant on Economic, Social, and Cultural Rights (ICESCR) was selected, as it is the broadest definition of the right to health in international human rights la
Major depressive disorder (MDD) is a prevalent psychiatric condition and poses a significant burden on public health. The underlying causes and mechanisms of depression remain poorly understood. There is a growing body of evidence linking microRNAs (miRNAs) to major depressive disorder (MDD). However, the causal relationship between miRNAs and MDD remains unclear. This study aimed to investigate t
Ovarian cancer remains a significant challenge in oncology, with current treatments having a high recurrence rate making further investigations into treatment targets and the heterogeneity of cancers necessary. As findings from cell lines models are hard to transfer to in vivo cancers, we wanted to explore possibilities to better integrate cell line and tissue omics data. To do so, this study leve
The composition of the tumour microenvironment has been reported as a meaningful predictor in triple-negative breast cancer’s (TNBC) prognosis and response to treatment and has allowed for implementation of new therapeutic approaches such as immunotherapy. Therefore, new spatially resolved approaches have arisen recently to unravel the properties of the microenvironment, ranging from spatial trans
Over recent years, mass spectrometry has become essential for advancing proteomics. A typical approach in proteomics involves digesting proteins into peptides, analyzing these peptides using liquid chromatography and mass spectrometry (LC-MS), and identifying them via tandem mass spectrometry (MS/MS). In Data-Dependent Acquisition (DDA), quantification is often achieved by counting MS/MS spectra o
High-grade serous carcinoma (HGSC) accounts for most ovarian cancer deaths, due to it often being diagnosed at late stages (III and IV). However, there is currently no early screening method sufficient for improving survival rates. HGSC primarily harbors structural variants, typically copy number (CN) aberrations caused by homologous recombination deficiency (HRD). CN can be calculated based on re
Antibodies are crucial components of the humoral immune responses, and their therapeutic potential is gaining attention. For antibodies to be effective, it is essential that they exhibit specificity towards antigens, mediate biological functions and are administered at the correct dosage. Given the numerous parameters influencing specificity, function, and optimal concentration, assessing what con
Recent studies have documented large declines in the abundance and diversity of a few well-studied groups of organisms. However, it is unclear how representative the results are for other, less studied groups such as spiders and other ground-dwelling arthropods. A few recent studies have reported large declines in spider abundance, but these have been performed in highly disturbed settings, and ma
