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Toxin-antitoxins (TAs) are prokaryotic two-gene systems composed of a toxin neutralized by an antitoxin. Toxin-antitoxin-chaperone (TAC) systems additionally include a SecB-like chaperone that stabilizes the antitoxin by recognizing its chaperone addiction (ChAD) element. TACs mediate antiphage defense, but the mechanisms of viral sensing and restriction are unexplored. We identify two Escherichia
Toxic small alarmone synthetase (toxSAS) enzymes constitute a family of bacterial effectors present in toxin-antitoxin and secretion systems. toxSASs act through either translation inhibition mediated by pyrophosphorylation of transfer RNA (tRNA) CCA ends or synthesis of the toxic alarmone adenosine pentaphosphate ((pp)pApp) and adenosine triphosphate (ATP) depletion, exemplified by FaRel2 and FaR
BACKGROUND: Platelet transfusions are frequently used in the intensive care unit (ICU), but current practices including used product types, volumes, doses and effects are unknown.STUDY DESIGN AND METHODS: Sub-study of the inception cohort study 'Thrombocytopenia and Platelet Transfusions in the ICU (PLOT-ICU)', including acutely admitted, adult ICU patients with thrombocytopenia (platelet count <1
BACKGROUND: Finding ways to prolong independence in daily life among older people would be beneficial for both individuals and society. Urban green spaces have been found to improve health, but only a few studies have evaluated the association between urban green spaces and independence in daily life. The aim of this study was to assess the long-term effect of urban green spaces on independence in
Behavioural science methods have significant potential to help policy makers, practitioners and energy programme managers design, implement and evaluate behavioural campaigns addressing hard-to-reach (HTR) energy users. But when facing budget and logistic constraints, how many real-life programmes actually follow through? How are behavioural science methods actually applied in a real-world setting
In this chapter, we argue that policy-making aiming to achieve environmentally sustainable transitions of the economy is in need of a solid empirical evidence base. Conventional measurement concepts used for example by the EU based on sector-classifications deliver highly biased pictures. We propose measurement concepts based on the use of green skills and human capital, validate key assumptions o
This study investigates the first films made by a female director, Kangdrun (T: Gangs sgron, གངས་ྒྲསྒྲོན་, Gangzhen, 岗珍, b. 1995) belonging to the Post-2000s Inland Tibet Class (ITC) generation. Following the experience of the Sinophone-Tibetan filmmaker Kangdrun in a Chinese language education environment, her films, and Tibetan cultural communities, this study discusses Kangdrun’s visual strateg
In the us, test score gaps by socioeconomic status and race increase with city size. This paper examines to what extent residential sorting on school quality can explain this fact. We combine 15 years of data on public elementary school studentsin North Carolina with geocoded school locations and proxy city size with a measure of school density in a local labor market. Assortative matching between
OBJECTIVES: To investigate how the co-occurrence of diabetes, hypertension and overweight/obesity is associated with pain following an exercise intervention for knee and hip osteoarthritis (OA).METHODS: Register-based cohort study. We included people from the Swedish Osteoarthritis Register who underwent education and exercise for knee or hip OA. Diabetes and hypertension were defined using medica
This chapter builds on a quality assessment of my teaching during the preparation seminars for the ‘degree project’ at the Malmö Academy of Music (hereafter: MAM). The evaluation is extended to review the way the course functioned on the basis of John Biggs’ (2003) theories on ‘constructive alignment’. As a result, this chapter also problematises the design of such coursework at a broader structur
Introduction: FLASH proton therapy (FLASH-PT) requires ultra-high dose rate (≥ 40 Gy/s) protons to be delivered in a short timescale whilst conforming to a patient-specific target. This study investigates the feasibility and constraints of Bragg peak FLASH-PT treatment planning, and compares the in silico results produced to plans for intensity modulated proton therapy (IMPT). Materials and method
This paper argues that accepting incommensurability can be a useful step for developing attractive hybrid theories to how to distribute scarce health-related resources. If one provides opportunity for distributive options to be incommensurable with respect to substantive criteria, one can hold on to substantive criteria while also providing room for decision processes to play a significant role. T
