Protein self-assembly is extensively used in nature to build functional biomolecules and provides a general approach to design molecular complexes with many intriguing applications. Although computational design of protein-protein interfaces remains difficult, much progress has recently been made in de novo design of protein assemblies with cyclic, helical, cubic, internal and lattice symmetries.

Background:The association between smoking and breast cancer prognosis remains unclear. The purpose of this study was to investigate whether preoperative smoking was associated with prognosis in different treatment groups.Methods:This population-based cohort consisted of 1065 breast cancer patients without preoperative treatment included between 2002 and 2012 in Lund, Sweden. Smoking status was ex

Molecular dynamics is used to simulate nanometer-sized copper strips. The strips are highly constrained and chosen to mimic thin films between two stiff layers. Further, the strips hold centrally placed straight through crack shaped voids, and are subjected to tensile displacement controlled mode I loading. The tensile stresses and displacements are studied. It is found that if a copper strip is 2

This paper reports on a case study in which an at- size application is ported onto a commercially available processor array. Its purpose is threefold: (1) Determine the suitability of processor arrays for this kind of application. (2) Develop a runtime software infrastructure that supports streaming applications on processor arrays. (3) Gather data and insights into the resulting system performanc

In this paper, an experimental investigation on the influence of glue on the low frequency vibroacoustic performance (up to 200 Hz) of wooden T-junctions is presented along with a discussion of modelling issues related to the junctions. The mock-ups studied represent cut-outs of full size timber floor assemblies typically used in Sweden. Their dynamic performance was first studied experimentally b

The public sphere and public reason have recently become key ideas in global governance, with most scholars expressing related transparency and accountability concerns. This article contends that if transnational public sphere(s) and the use of reason in global policy-making aim to reinforce the common good and justice, they must go beyond the procedural concerns of transparency and accountability

Based on an ethnography at the Swedish Public Employment Service, this paper offers a typology of how employees managed to obey tasks they would rather not perform. It is argued that earlier studies of workplace obedience have tended to focus on a single mood in which the actor obeys: despair, cynicism, or seduction. Here, the movement between these moods is analysed. To pass from despair to cynic

Regioselective O-alkylation of an amide to form the corresponding imidate is a common synthetic problem, often resulting in varying amounts of N-alkylation. Screening existing methods for converting amides to imidates gave inconsistent or irreproducible results, sometimes affording N-alkylamide as the major product. A simple and reliable protocol for amide O-alkylation with complete regioselectivi

Numerous applications of membrane processes are feasible in pulp mills. The challenges inherent in these applications vary. High pH and high temperature call for ceramic membranes when treating spent pulping liquors, whereas low-cost membranes are needed when treating dilute process streams in mechanical pulp mills. Ultrafiltration has been used to recover lignosulphonate in sulphite pulp mills fo

Carroll's paper (Carroll) is most welcomed and shows that the weaker language is still to be explored from various points of views. Over twenty years after the publication of Schlyter's paper, “The weaker language in bilingual Swedish-French children”, not only is the topic of the weaker language of simultaneous bilinguals still a clearly under-researched area, but it is also, as Carroll shows, a

Photoisomerization of 1,1′-diethyl-2,2′-carbocyanine iodide (pinacyanol) in alcohols was investigated by means of femtosecond time-resolved absorption spectroscopy. Only one out of two possible types of photoisomer was found. Viscosity-dependent kinetics indicate that the excited state dynamics consist of two parts, associated with a barrier-crossing observed in the blue side of stimulated emissio

The electrical properties of ZrO2 and HfO2 gate dielectrics on n-InAs were evaluated. Particularly, an in situ surface treatment method including cyclic nitrogen plasma and trimethylaluminum pulses was used to improve the quality of the high-κ oxides. The quality of the InAs-oxide interface was evaluated with a full equivalent circuit model developed for narrow band gap metal-oxide-semiconductor (

The aim of the document is to identify and discuss a number of growth paths that might be explored to promote innovationdriven development in Sub-Saharan Africa. The document adopts a broad perspective of innovation, examining framework conditions, fundamental prerequisites, drivers and focal areas for innovation. The document addresses a spectrum of issues andtopics ranging from regional and glob

We demonstrate improved performance due to enhanced electrostatic control achieved by diameter scaling and gate placement in vertical InAs-GaSb tunneling field-effect transistors integrated on Si substrates. The best subthreshold swing, 68 mV/decade at VDS=0.3 V, was achieved for a device with 20-nm InAs diamter. The on-current for the same device was 35 µA/µm at VGS=0.5 V and VDS=0.5 V. The fabri

We examine strategic self-ignorance—the use of ignorance as an excuse toover-indulge in pleasurable activities that may be harmful to one’s future self. Our model shows that guilt aversion provides a behavioral rationale for present-biased agents to avoid information about negative future impacts of such activities. We then confront our model with data from an experiment using prepared, restaurantWe examine strategic self-ignorance—the use of ignorance as an excuse to over-indulge in pleasurable activities that may be harmful to one’s future self. Our model shows that guilt aversion provides a behavioral rationale for present-biased agents to avoid information about negative future impacts of such activities. We then confront our model with data from an experiment using prepared, restauran

Background: The development of social assistive robots is an approach with the intention of preventing and detecting falls among seniors. There is a need for a relatively low-cost mobile robot with an arm and a gripper which is small enough to navigate through private homes. Material and methods: User requirements of a social assistive robot were collected using workshops, a questionnaire and inte

This paper investigates a pairwise kidney exchange program that includes patient-donor pairs in which the patients can receive a kidney across the blood group barrier from their own donors. Patients in such pairs gain strictly by an exchange if they are matched to a fully compatible donor. We study the set of priority matchings where the number of patients matched to fully compatible donors is max

Increasing trends of natural organic matter (NOM) in surface water in Nordic countries may cause future problems for drinking water producers. Emerging membrane technology, such as ultrafiltration (UF) and nanofiltration (NF), has the potential to produce safe drinking water of good quality from sources with high organic concentrations. In the present pilot study, surface water from three sources

This paper presents a combinatorial auction which is of particular interest when short completion times are of importance. It is based on a method for approximating the bidders' preferences over two types of items when complementarity between the two may exist. The resulting approximated preference relation is shown to be complete and transitive at any given price vector. It is shown that an appro