Replication of reported associations is crucial to the investigation of complex disease. More than 100 SNPs have previously been reported as associated with allergic rhinitis (AR), but few of these have been replicated successfully. To investigate the general reproducibility of reported AR-associations in candidate gene studies, one Swedish (352 AR-cases, 709 controls) and one Singapore Chinese po

Monoamino and diamino analogues of Troger's base have been synthesized by palladium-catalyzed aminations of the corresponding dihalo analogues using low catalyst loadings. Depending on the nature of the dihalo analogue (Br or 1). catalyst loading and the scale of the reaction, monoamino-monohalo and/or diamino analogues of Troger's base were obtained.

A common usage for electroactive polymers (EAPs) is in different types of actuators, where advantage is taken of the deformation of the polymer due to an electric field. It turns out that time-dependent effects are present in these applications. One of these effects is the viscoelastic behavior of the polymer material. In view of the modeling and simulation of applications for EAP within a continu

The aim of this study was to assess whether a school-based program with expanded physical education lessons was effective in increasing children's physical capacity and in preventing excessive weight gain in children. The study performed in 2000-2003 comprised 132 children, 73 boys and 59 girls at baseline 6-9 years and in follow-up 9-12 years, attending two different schools with a similar size,

Thermal neutron detector based on films of (B4C)-B-10 have been developed as an alternative to He-3 detectors. In particular, The Multi-Grid detector concept is considered for future large area detectors for ESS and ILL instruments. An excellent signal-to-background ratio is essential to attain expected scientific results. Aluminium is the most natural material for the mechanical structure of of t

A detailed diatom record from Lake Kälksjön, west-central Sweden, reveals two periods of abrupt ecological change correlative with the 8.2 ka cooling event. Using a combination of abrupt step changes and piece-wise linear regressions, the diatom data were analysed for change points over time, and two sudden and large events that are described as regime shifts were detected. During the first event

Investigation into predictors for treatment outcome is essential to improve the clinical efficacy of therapeutic multipotent mesenchymal stromal cells (MSCs). We therefore studied the possible harmful impact of immunogenic ABO blood groups antigens - genetically governed antigenic determinants - at all given steps of MSC-therapy, from cell isolation and preparation for clinical use, to final recip

A period of two and a half millennia separates us from the Classical period of ancient Greece. Nevertheless, looking at ancient Greek medicine from the perspective of modern health economics is an interesting endeavour in that it increases our understanding of the ancient world and provides insights into contemporary society. Ancient Greece is rightly famous for pioneering secular and scientific m

Popular Abstract in Swedish Syftet med sjukgymnastik är att främja hälsa och välbefinnande och hjälpa människor till aktivitet och delaktighet vid sjukdom och skada. Professionen är påverkad av olika hälsoparadigm som hör samman med olika kunskapstraditioner. Det biomedicinska hälsoparadigmet har en dualistisk syn på människan, där normalitet ses som standard, och där syftet är att kurera och korrThe aim of physiotherapy is to promote health and well-being, and to facilitate increased activity and participation of individuals with diseases and injuries. The profession is influenced by different health paradigms which have emerged from different knowledge traditions. The biomedical paradigm of health adopts a dualistic view of mankind in which the normal is regarded as the standard, and the

Asthma and allergic rhinitis are diseases that cause major disability and illness in all ethnic groups and ages. It is well established that allergic rhinitis and asthma are closely linked entities and more than 75 % of the patients with asthma reports concomitant rhinitis. Asthma is also closely associated to bronchial hyperresponsiveness, and a large part of patients with rhinitis alone show a r

The concept of “style of thought” or Denkstil is today probably primarily associated with the Polish microbiologist and philosopher of science Ludwik Fleck and his writings from the 1930s. It was however used quite extensively already by Karl Mannheim in his writings on the sociology of knowledge from the 1920s. Quite interestingly, the concept of style of thought was also used twice by Rudolf Car

Desiccation of the Sahara since the middle Holocene has eradicated all but a few natural archives recording its transition from a "green Sahara" to the present hyperarid desert. Our continuous 6000- year paleoenvironmental reconstruction from northern Chad shows progressive drying of the regional terrestrial ecosystem in response to weakening insolation forcing of the African monsoon and abrupt hy

Background: The yeast Saccharomyces cerevisiae provides unique opportunities to study roles and regulation of aqua/glyceroporins using frontline tools of genetics and genomics as well as molecular cell and systems biology. Scope of review: S. cerevisiae has two similar orthodox aquaporins. Based on phenotypes mediated by gene deletion or overexpression as well as on their expression pattern, the y

Recordings of the acoustic activity of free-swimming groups of echolocating dolphins increase the likelihood of collecting overlapping click trains, originating from multiple individuals, in the same set of data. In order to evaluate the click properties of each individual based on such recordings it is necessary to identify which clicks originate from which animal. This paper suggests a computati