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Activation of macroautophagy/autophagy, a key mechanism involved in the degradation and removal of aggregated proteins, can successfully reverse Huntington disease phenotypes in various model systems. How neuronal autophagy impairments need to be considered in Huntington disease progression to achieve a therapeutic effect is currently not known. In this study, we used a mouse model of HTT (hunting

This deliverable maps the prevailing polycentric settings of six studied countries. The studied countries are the partner countries for the NEWCOMERS project, i.e. Germany, Italy, the Netherlands, Slovenia, Sweden and the United Kingdom. In this report, the countries' polycentric settings will be described in relation to the polycentric framework developed in WP 2, with specific focus on the techn

Precipitation is intrinsically associated with high uncertainty, which is exacerbated exponentially over time—especially concerning climate change. However, the current design practice in urban drainage infrastructure remains firmly bound to deterministic assumptions regarding the design load. This approach is too simplified—focusing only on the return period of the design event—and ignores the co

Morgan Johansson vägrar utreda narkotikapolitiken och anser den svenska modellen överlägsen. Men problemet är alldeles för allvarligt för att ministerns förutfattade meningar ska få styra, skriver flera debattörer.

Dokument formas av människan, men dokument formar också människan. Vad innebär detta, hur går det till och vilka är konsekvenserna? Typografi och mediers materialitet står i centrum för diskussionen och relateras till både historiska och samtida aspekter.

Data-driven software is becoming prevalent, especially with the advent of machine learning and artificial intelligence. With data-driven systems come both challenges - to keep collecting and maintaining high quality data - and opportunities - open innovation by sharing data with others. We propose Open Data Collaboration (ODC) to describe pecuniary and non-pecuniary sharing of open data, similar t

This paper reports the results of a choice experiment designed to estimate the private welfare costs of stay-at-home policies during the COVID-19 pandemic. The study is conducted on a large and representative sample of the Swedish population. The results suggest that the welfare cost of a one-month stay-at-home policy, restricting non-working hours away from home, amounts to 9.1 percent of Sweden'

There is a growing body of literature investigating if and how monetary policy impacts income inequality. Labor unions are generally found to mitigate income inequality and recent literature highlights that changing labor mar- ket structures, such as de-unionization, may be important for monetary pol- icy. This paper tests whether labor unions influence the impact of monetary shocks on income ineq

The Swedish policy response to covid-19 stands out as exceptional in international comparisons. The approach adopted is fundamentally determined by the Swedish constitution. Three articles of the constitution are central for this explanation. The first one guarantees the freedom of movement for Swedish citizens, thus ruling out the use of nation-wide lockdowns as an instrument in peacetime. The se

Three new for science genera, i.e.: Erichansenia S. Y. Kondr., Kärnefelt et A. Thell for the ‘Caloplaca’ epithallina group of the subfamily Xanthorioideae, as well as Lendemeriella S. Y. Kondr. for the Caloplaca reptans group, and Pisutiella S. Y. Kondr., L. Lőkös et E. Farkas for the Caloplaca conversa group of the subfamily Caloplacoideae of the Teloschistaceae, are described on the basis of res

Microplastics have recently become a growing environmental issue, whereas the smaller fractions, nanoplastics, have received less attention. Due to their small size, nanoplastics may affect organisms differently and potentially more severely than larger microplastics. In natural environments nanoplastics also interact with organic material and form larger aggregates, which may, potentially, reduce

We have used Fourier transform infrared spectroscopy (FTIR) to characterise the chemical and structural composition of the tendons of the rotator cuff and to identify structural differences among anatomically distinct tears. Such information may help to identify biomarkers of tears and to provide insight into the rates of healing of different sizes of tear. The infrared spectra of 81 partial, smal

It has been proved that time-resolved total reflectance FT-IR spectroscopy is a useful tool for investigating acetic acid diffusion in silk fibroin film and conformational transition of silk fibroin. Acetic acid could induce the construction of highly dominating content of β-sheet conformation in the silk fibroin film, in addition, the kinetic curve of organic solvent diffusion was similar to that

Rwanda has undertaken a land registration and titling program since 2008 with a registration of 10.3 million land parcels in 2013. The aim of this paper is to investigate the early effects of the program on tenure security and agricultural investments since few studies have been carried out in this research area. The study was undertaken in Musanze district in Northern Rwanda, with specific focus

A key feature of silk fibres is the carefully controlled assembly and directed growth that produce hierarchical structures at all length scales. The final result is a material of outstanding strength, functional flexibility and often with self-healing properties. Some salient results in silk research are reviewed to identify the fundamental ‘bio-principles’ that make silk a remarkable system to st

Background: Up to one third of adults have been estimated to have rotator cuff tendon (RCT) tears. Larger RCT tears are associated with poorer scores and function, and are more likely to re-rupture after surgical repairs, hence there is a need for earlier identification and treatment. The aim of this study was to identify biomarkers of RCT tear pathologies to aid accurate identification and monito

BackgroundRotator cuff tears pose a huge socioeconomic burden. Our study uses Fourier transform infrared spectroscopy (FTIR) as it is a quick, non-manipulative and non-destructive test, which can identify a wide range of chemical targets from small intraoperatively obtained specimens. The aim of this study was (i) to characterise the chemical and structural composition of rotator cuff tendons and