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We have calculated the reorganization energy for the intramolecular electron transfer between the reduced type 1 copper site and the peroxy intermediate of the trinuclear cluster in the multicopper oxidase CueO. The calculations are performed at the combined quantum mechanics and molecular mechanics (QM/MM) level, based on molecular dynamics simulations with tailored potentials for the two copper
This paper explores a global trend where universities are collaborating with local government, industry and civic organisations to advance the sustainable transformation of a specific town, city or region. With empirical evidence, we argue that this function of ‘cocreation for sustainability’ could be interpreted as the seeds of an emerging, new mission for the university. We demonstrate that this
The forms of water and their thermal stability in bedded salt are crucial in determining the material's suitability for heat-generating nuclear waste storage. Here we show first-of-its-kind incoherent inelastic neutron scattering (IINS) results of bedded salts to distinguish three water environments: intergranular water molecules confined to grain boundaries, water trapped as brine in fluid inclus
Segmentation is an important task in all kinds of image analysis. In medical image analysis segmentation has a great clinical value since the aim could be to localize organs or pathologies in order to raise the quality of diagnoses. This thesis consists of three papers where different segmentation techniques have been applied to different imaging modalities. In the first paper a full computer assi
We present a set of spectrally and temporally resolved clinical fluorescence data-with two separate excitation wavelengths-that was recorded in vivo. We demonstrate that data in the spectral and temporal domains are in certain ways coupled and provide a method for integrated and effective parameterization of spectrally and temporally resolved fluorescence (i.e., time-resolved emission spectra). Th
A survey on household waste sorting and disposal habits was conducted in Sweden to investigate behavioral patterns of recycling in a context in which wide measures are taken to promote and encourage pro-environmental behavior by making it easy and convenient. 207 residents of three cities in southern Sweden, Lund, Malmö and Helsingborg, responded to an online questionnaire survey. Relations betwee
Abstract in Undetermined OBJECTIVES: To calculate comparative incremental cost-effectiveness ratios (cost per quality-adjusted life year, QALY) and net marginal benefits for retigabine as add-on treatment for patients with uncontrolled focal seizures as compared to add-on lacosamide treatment and no add-on treatment, respectively. MATERIALS & METHODS: Calculations were performed using a valida
Most climate change scenarios predict that the variability of weather conditions will increase in coming decades. Hence, the frequency and intensity of freeze-thaw cycles in high-latitude regions are likely to increase, with concomitant effect on soil carbon biogeochemistry and associated microbial processes. To address this issue we sampled riparian soil from a Swedish boreal forest and applied t
BACKGROUND: Isokinetic dynamometry is a useful tool to objectively assess muscle strength of children and adults in athletic and rehabilitative settings. This study examined test-retest reliability of isokinetic knee strength measurements in children aged 8 to 10 years and defined limits for the minimum difference (MD) in strength that indicates a clinically important change. HYPOTHESIS: Isokine
Prospective isolation is critical for understanding the cellular and molecular aspects of stem cell heterogeneity. Here, we identify the cell surface antigen CD9 as a positive marker that provides a simple alternative for hematopoietic stem cell isolation at high purity. Crucially, CD9 affords the capture of all hematopoietic stem cells in murine bone marrow in the absence of contaminating populat
It can be said that literary texts do not have any obligation to reality, and that literature destabilises our relation to normal use of words and to established perspectives. Literature is in relation with something that cannot be explained or conceptualised. In this respect literature is close to religion. Literature invites us to believe in something that is unreal and beyond ordinary life. In
Vertebral compression fractures (VCFs) are the most prevalent fractures in osteoporotic patients. The classical conservative management of these fractures is through rest, pain medication, bracing and muscle relaxants. The aim of this paper is to review prospective controlled studies comparing the efficacy and safety of minimally invasive techniques for vertebral augmentation, vertebroplasty (VP)
Angular correlations between charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV for transverse momentum ranges within 0.5 < P-T,P-assoc < P-T,P-trig < 4 GeV/c. The correlations are measured over two units of pseudorapidity and full azimuthal angle in different intervals of event multiplicity, and exp
Attosecond pulses are used to study electron dynamics in atoms and molecules. In this thesis, schemes to control the generation of attosecond pulses and pulse-shaping techniques to compress the pulses are presented. Generation of attosecond pulses requires high intensity, which is reached by focusing a pulsed femtosecond laser. The emitted pulses come isolated or in an attosecond pulse train (APT
The move towards fire performance-based design in building and transport regulations has led to an increased use of fire models. This increased use of these models and the evolution of different regulations have put higher demands on the predictive capability of fire models. The purpose of this paper is to give an overview of different activities relating to the validation and verification of comp
Generalized frequency division multiplexing (GFDM) is a new concept that can be seen as a generalization of traditional OFDM. The scheme is based on the filtered multi-carrier approach and can offer an increased flexibility, which will play a significant role in future cellular applications. In this paper we present the benefits of the pulse shaped carriers in GFDM. We show that based on the FFT/I
Tasquinimod, an orally active quinoline-3-carboxamide, binds with high affinity to HDAC4 and S100A9 in cancer and infiltrating host cells within compromised tumor microenvironment inhibiting adaptive survival pathways needed for an angiogenic response. Clinical trials document that as low as 0.5-1mg tasquinimod/day is therapeutic against castrate resistant metastatic prostate cancer. Tasquinimod i
