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As biological surfactants, bile salts (BSs), play important roles in biological processes, i.e., food digestion, but also in BS-related diseases, as well as in applications. In this thesis, the main focus was to gain a fundamental understanding of the intermolecular interactions between BSs and cationic block copolymers with the purpose of developing new BS sequestrants that are used in the treatm
Objective: The purpose of the study was to examine associations between self-esteem and symptoms of anxiety and depression among young adults who lost a parent to cancer. Methods: Older adolescents and young adults, aged 16 to 28 years, who had lost their parent to cancer and had accepted an invitation to join a support group, completed a questionnaire 5 to 8 months after the loss and a similar qu
In this article, we study microscopic properties of a two-dimensional Coulomb gas ensemble near a conical singularity arising from insertion of a point charge in the bulk of the droplet. In the determinantal case, we characterize all rotationally symmetric scaling limits (“Mittag-Leffler fields”) and obtain universality of them when the underlying potential is algebraic. Applications include a cen
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Peirce's best idea, and the one least implemented by himself and his followers, is that of an ethics of terminology. Using this ethics as a tool, we suggest that many Peircean terms are in fact misleading, or, as he said himself at the end of his life, "injurious."From the point of view of cognitive semiotics, there is no reason to abide by Peirce's definition of semiosis, but, taking up the two q
This thesis is ta study of the intersection between dark green spirituality and the green movement in relation to climate change and ecological crisis, and it explores how some ecologically concerned people try to orientate themselves in facing the challenges and especially the role of spirituality in this context. The study is set in the period 2009–2015, and it is based in fieldwork conducted i
Identification of a single molecular trait that is determinant of common malignancies may serve as a powerful diagnostic supplement to cancer type-specific markers. Here, we report a DNA methylation mark that is characteristic of seven studied malignancies, namely cancers of lung, breast, prostate, pancreas, colorectum, glioblastoma and B cell chronic lymphocytic leukaemia (CLL) (n = 137). This ma
Introduction: Dysfunction of immunoglobulins (Igs) has been detected in association with antiepileptic drugs (AEDs) and in newly diagnosed epilepsy patients. The aim of this study was to evaluate the effect of clinical features and the current or past use of AEDs on serum Ig concentrations in a well-examined group of patients with refractory epilepsy. Patients and methods: Using a nephelometric me
DNA methylation patterns have been recognised as cancer-specific markers with high potential for clinical applications. We aimed at identifying methylation variations that differentiate between breast cancers and other breast tissue entities to establish a signature for diagnosis. Candidate genomic loci were analysed in 117 fresh-frozen breast specimens, which included cancer, benign and normal br
Background: Lead-time is defined as the time by which screening advances the diagnosis compared with absence of screening. A sufficiently long lead-time needs to be achieved so that cancer can be detected while still curable. A very short lead-time may indicate poor sensitivity of the screening test, while a very long lead-time suggests overdiagnosis. Material and methods: In the first screening r
Reflective reconfigurable intelligent surface (RIS) technology is regarded as an innovative, cost- and power-effective solution that aims at influencing the wireless channel through controlled scattering. The technology can be realized by using metamaterials and/or resonant elements that scatter electromagnetic waves with a configurable phase shift. Most of the previous work on beamforming techniq
OBJECTIVE: To identify and characterize genetic loci associated with the risk of developing anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV).METHODS: Genetic association analyses were performed after Illumina sequencing of 1,853 genes and subsequent replication with genotyping of selected SNPs in a total cohort of 1110 Scandinavian cases with granulomatosis with polyangiit
OBJECTIVES: Fatigue is common and severe in primary Sjögren's syndrome (pSS). The aim of this study was to identify genetic determinants of fatigue in pSS through a genome-wide association study.METHODS: Patients with pSS from Norway, Sweden, UK and USA with fatigue and genotype data available were included. After genotype imputation and quality control, 682 patients and 4 966 157 genetic markers
Ett viktigt mål för samhället, särskilt för utbildningssystemen, är att vi människor blirbättre på att få syn på växter och på deras betydelse i ekosystemen. Vi behöver över-vinna vad som benämns ‘växtblindhet’. I denna artikel föreslår vi att variationsteoriär en bra utgångspunkt i utbildning och utvärdering av växtidentifiering inom högreutbildning. Vi redovisar exempel från svensk universitetsu
