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Pancreatic cancer is one of our most lethal malignancies. Despite substantial improvements in the survival rates for other major cancer forms, pancreatic cancer survival rates have remained relatively unchanged since the 1960s. Pancreatic cancer is usually detected at an advanced stage and most treatment regimens are ineffective, contributing to the poor overall prognosis. Herein, we review the cu

This work treats multi-pitch estimation, and in particular the common misclassification issue wherein the pitch at half of the true fundamental frequency, here referred to as a sub-octave, is chosen instead of the true pitch. Extending on current methods which use an extension of the Group LASSO for pitch estimation, this work introduces an adaptive total variation penalty, which both enforce grou

Disrupted high school experiences, including dropout, are educational consequences for many youth with histories of homelessness. Using an ecological resilience prediction model (ERPM) based on the literature on resilience in at-risk youth, the study followed 82 youth who were initially homeless for a 2-year period, to identify predictors of participating in school. Female sex and increased durati

In order to understand where and how the Swedish public access their medicines, especially prescribed medicines, an online survey was conducted as a pilot study during April and May 2016. Among a collection of 155 answers, the data shows that, although a majority of the respondents feel hesitated and negative towards shopping prescribed medicines online, a tendency is demonstrated that people woul

National incidence and prevalence estimates of homelessness in Canadian youth are unknown. However, a recent annual profile of shelter users in a large urban centre estimated that one in five consumers of emergency shelter services are youth. Adolescence is a period of vulnerability from developmental perspective. In their progression from childhood to adulthood, youth have multiple role transitio

The aim of this article is to analyze reported changes in outdoor mobility, increased/unchanged/decreased, for a sample of older people (>62 years) in two regions in Sweden, who have transitioned from a two-person to a single-person household during the two years since the study was conducted. The target group (N=162) consists of all people who had transitioned to a single-person household in a ra

Successful optimization of a given lead scaffold requires thorough binding-site mapping of the target protein particular in regions remote from the catalytic center where high conservation across protein families is given. We screened a 361-entry fragment library for binding to the aspartic protease endothiapepsin by crystallography. This enzyme is frequently used as surrogate for the design of re

Crystallographic screening of the binding of small organic compounds (termed fragments) to proteins is increasingly important for medicinal chemistry-oriented drug discovery. To enable such experiments in a widespread manner, an affordable 96-compound library has been assembled for fragment screening in both academia and industry. The library is selected from already existing protein-ligand struct

Today the identification of lead structures for drug development often starts from small fragment-like molecules raising the chances to find compounds that successfully pass clinical trials. At the heart of the screening for fragments binding to a specific target, crystallography delivers structural information essential for subsequent drug design. While it is common to search for bound ligands in

Fragment-based lead discovery (FBLD) has become a pillar in drug development. Typical applications of this method comprise at least two biophysical screens as prefilter and a follow-up crystallographic experiment on a subset of fragments. Clearly, structural information is pivotal in FBLD, but a key question is whether such a screening cascade strategy will retrieve the majority of fragment-bound

Denna artikel diskuterar en ny form av snabbt expanderande praktiker från tidigt 2000-tal och som erbjuds av privata företag eller entreprenörer (lekmannaterapeuter). I fokus står självförverkligande och helande. Jag har med hjälp av verktyg från Ritual Studies valt att analysera dessa praktiker som en form av individ-centrerade riter som designas för att lindra smärta och lågt självförtroende förThis article discusses a new form of practices which are offered by private companies or entrepreneurs (layman therapists) whose practices focusing on self-development and healing rapidly expanded in the early 2000s in Sweden. I have chosen to analyze these practices from a Ritual Studies perspective as individual-centered rites designed to remedy ill health and low self-esteem and to build new, p

Protein-lipid complexes have broad and specific effects against cancers of different origins. HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a complex of partially unfolded α-lactalbumin and oleic acid that kills a wide range of tumor cells but leaves healthy differentiated cells unaffected. Therapeutic efficacy of HAMLET has been demonstrated in several animal models, without appa

This paper explores the context, problems, quality, and challenges of local governance in four Central Asian countries: Kazakhstan, Kyrgyzstan, Tajikistan, and Uzbekistan. The prime focus is on the question of whether local governments in this region perform their functions in an effective and efficient way. It looks at the four conditions – contextual, structural, institutional and human resource

This thesis analyses how the capital structures of financial and non-financial firms affect each other and how shocks in the financial sector affect investments in non-financial firms. The thesis consists of three self-contained essays.The first essay provides new evidence on the capital structure determinants of non-financial firms and contributes to the discussion concerning the effect of a regu