Discovery of Selective Ligands for the Modulation of NMDA Receptors
NMDA receptors are part of the family iGluRs that regulate the flow of positive ions, such as Na+, K+ and Ca2+, by ligand gating. Upon activation with Glutamate, the channel opens, and a flowthrough of ions occurs. NMDA receptors are unique in that they require the co-agonist glycine for activation and that they exhibit voltage-dependent ion flow due to Mg2+ blockade. The NMDA receptors have three