The role of mechanosensitive ion channels in the release of pancreatic hormones and type 2- diabetes
Pancreatic beta cells play a critical role in type 2 diabetes (T2D) development and progression. Therefore, deciphering the full mechanism behind glucose-stimulated insulin secretion is of great interest. Glucose elicits insulin secretion by being metabolized to ATP, which closes the ATP-dependent K+ channel, leading to accumulation of positive charges inside the beta-cell, beta-cell depolarizatio
