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CF-related diabetes (CFRD) is a prevalent comorbidity in people with Cystic Fibrosis (CF), significantly impacting morbidity and mortality rates. This review article critically evaluates the current understanding of CFRD molecular mechanisms, including the role of CFTR protein, oxidative stress, unfolded protein response (UPR) and intracellular communication. CFRD manifests from a complex interpla

We conducted measurements of K-+He3→πYN+N′ reactions using a 1GeV/cK - beam, with the objective of understanding the broad decay width of K̄NN (approximately twice as broad as that of Λ(1405) considered to be the K̄N quasibound state). We successfully reproduced distributions of the πYN invariant mass and momentum transfer for πYN using model-fitting functions for K̄NN formation and quasifree K̄ a

Importance: There is uncertainty about whether prolonged infusions of β-lactam antibiotics improve clinically important outcomes in critically ill adults with sepsis or septic shock. Objective: To determine whether prolonged β-lactam antibiotic infusions are associated with a reduced risk of death in critically ill adults with sepsis or septic shock compared with intermittent infusions. Data Sourc

The paper recommends a values-driven regeneration of research ethics for ethnography. In contrast to the current regulatory version of research ethics we propose a more subtle, field-oriented and traditional version, grounded in ethnographic experience. The paper is in three parts. The first part highlights the tacit assumptions of current systems of ethical approval for social research and their

Background: Stroke is a leading cause of acquired disability in adults worldwide, and the burden of stroke is projected to increase. Current long-term stroke outcome data including functional status, activity, and participation limitations as well as information on health-related quality of life (HRQoL) are vital for future rehabilitation and resource planning of stroke survivors. Methods: First-e

In this paper, we describe the extraction of all the location entries from a prominent Swedish encyclopedia from the early 20th century, the Nordisk Familjebok 'Nordic Family Book.' We focused on the second edition called Uggleupplagan, which comprises 38 volumes and over 182,000 articles. This makes it one of the most extensive Swedish encyclopedias. Using a classifier, we first determined the ca

Background: The COVID-19 pandemic has necessitated changes in European healthcare systems, with a significant proportion of COVID-19 cases being managed on an outpatient basis in primary healthcare (PHC). To alleviate the burden on healthcare facilities, many European countries developed contact-tracing apps and symptom checkers to identify potential cases. As the pandemic evolved, the European Un

Little is known about risk factors for central nervous system (CNS) relapse in mature T-cell and natural killer cell neoplasms (MTNKNs). We aimed to describe the clinical epidemiology of CNS relapse in patients with MTNKN and developed the CNS relapse In T-cell lymphoma Index (CITI) to predict patients at the highest risk of CNS relapse. We reviewed data from 135 patients with MTNKN and CNS relaps

In health, the human heart is able to match ATP supply and demand perfectly. It requires 6 kg of ATP per day to satisfy demands of external work (mechanical force generation) and internal work (ion movements and basal metabolism). The heart is able to link supply with demand via direct responses to ADP and AMP concentrations but calcium concentrations within myocytes play a key role, signalling bo

Background: Acne vulgaris is a multifactorial disease of the pilosebaceous unit of human skin. Previous studies have identified an acne-associated dysbiosis of the skin microbiome. Objectives: This dysbiosis was mainly determined for Cutibacterium acnes. However, detailed analyses combining qualitative and quantitative aspects are scarce, also regarding the possible contribution of other skin bact

Both trio and population designs are popular study designs for identifying risk genetic variants in genome-wide association studies (GWASs). The trio design, as a family-based design, is robust to confounding due to population structure, whereas the population design is often more powerful due to larger sample sizes. Here, we propose KnockoffHybrid, a knockoff-based statistical method for hybrid a

We investigate sequential two-stage admission systems with public and private schools. A sequential notion of truthfulness, called straightforwardness, is introduced. Contrary to one-stage systems, sequentiality leads to a trade-off between the existence of a straightforward equilibrium and non-wastefulness. We identify the unique set of rules for two-stage systems that guarantees the existence of

Objective: A growing body of evidence suggests patients with late-onset seizures are at an increased risk of stroke, but the potential for reducing cardiovascular morbidity through risk factor screening and management is unknown. We aim to determine whether individuals with new-onset unprovoked seizures after middle age should undergo vascular risk assessment. The long follow-up needed to assess s

Many services have become digitized in society, including health services. Although there are many advantages to eHealth services, some segments of the population cannot reap those benefits. Objectives: This study aimed to: 1- describe how people with intellectual disability use the internet in Sweden; and 2- understand the nature of the contextual and personal barriers these users face when tryin

I det nazistiska Tyskland framställdes Adolf Hitler som en frälsargestalt. Trots den intensiva propagandan fanns det tyskar, varav flera var högt uppsatta militärer och diplomater, som betraktade Hitler och det nationalsocialistiska partiet som en fara för den tyska nationens fortlevnad. De hade avlagt en ed och svurit lojalitet mot Führern men de såg sig nödgade att begå högförräderi för att räd

Here we study the role of negative shifts in public opinion in the economic lives of under-represented racial groups by investigating sudden changes in views towards Asian people following the anti-Chinese rhetoric that emerged with the COVID-19 pandemic, and associated changes in employment status and earnings in the US labour market. Using data from the Current Population Survey, we find that, u

Background/introductionFlecainide is a commonly used efficient antiarrhythmic drug against atrial fibrillation (AF). P-wave indices reflect the atrial substrate and can predict incident AF, but their role as predictors of treatment outcomes for flecainide-treated AF patients are unknown.PurposeTo assess if P-wave indices can predict efficacy outcomes in long-term flecainide treated AF patients.Met

Purpose: Application of standardised and automated assessments of head computed tomography (CT) for neuroprognostication after out-of-hospital cardiac arrest. Methods: Prospective, international, multicentre, observational study within the Targeted Hypothermia versus Targeted Normothermia after out-of-hospital cardiac arrest (TTM2) trial. Routine CTs from adult unconscious patients obtained > 48 h