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Early Holocene history of the Baltic Sea, as reflected in coastal sediments in Blekinge, southeastern Sweden

Integrated palaeoecological studies of two fiord sediment sequences in the province of Blekinge, SE Sweden, covering the time span 11,000-5000 cal BP, reveal the timing and the environment for the Ancylus Lake/Littorina Sea transition 9800-8500 cal BP. The first ingression of saline water into the Baltic Sea through the Danish Straits occurred earlier than formerly assumed. New evidence, particula

Formation of a liquid crystalline phase from phosphatidylcholine at the oil-aqueous interface

Adsorption of phospholipid (1,2-dioleoyl-sn-glycero-3-phosphatidylcholine) and formation of a surface phase at the oil-water interface has been followed by using ellipsometry. The properties of the interfacial phase were found to depend strongly on whether phospholipid was added to the oil phase or to the aqueous phase as liposomal structures. In the latter case a monolayer formed, while if the ph

Rational design and purification of human Bruton's tyrosine kinase SH3-SH2 protein for structure-function studies

Bruton's tyrosine kinase (Btk) is a cytoplasmic protein tyrosine kinase consisting of N-terminal pleck-strin homology (PH) domain followed by Tec homology (TH) domain, Src homology 3 and 2 (SH3 and SH2) domains, and a C-terminal kinase domain. Mutations in the human BTK gene cause the severe immunodeficiency disease X-linked agammaglobulinemia (XLA). The structural and functional basis of several

Effects of intrapleural mitoxantrone and mepacrine on malignant pleural effusion--a randomised study

30 patients with malignant pleuritis were randomised to be treated, either with intrapleural instillation of mepacrine chloride or with mitoxantrone. The patients were evaluated with chest X-ray and a symptom questionnaire during a follow-up period of 12 weeks. Mitoxantrone levels in the pleural space and plasma were measured at different time points in some of the patients. High concentrations of

Strata of intervenient concepts in normative systems

In a legal system, there are different strata of concepts exhibiting the pattern of a network. Our paper presents an algebraic representation of legal concepts as intermediate between factual events and circumstances on one hand, and deontic positions, on the other. In this representation, we use the notion of "intervenient" as a theoretical tool, defining intervenients in terms of weakest grounds

MHC and kin discrimination in juvenile Arctic charr, Salvelinus alpinus (L.)

Kin recognition and discrimination ale thought to occur in several species of various taxonomic groups. In salmonid fish, juveniles can discriminate between odours of siblings and nonsiblings from the same population even if the odour donors and the test fish have been reared separately since fertilization. This indicates that some genetic factor is important in the recognition process. The mechan

Cloud-nucleating properties of the Amazonian biomass burning aerosol: Cloud condensation nuclei measurements and modeling

The cloud-nucleating properties of the atmospheric aerosol were studied in an area under strong influence of vegetation burning. The measurements were part of Large-Scale Biosphere Atmosphere Experiment in Amazonia-Smoke Aerosols, Clouds, Rainfall and Climate (LBA-SMOCC) and were carried out at a ground site located in the state of Rondonia in southwestern Amazonia, Brazil, September to November 2

Physicochemical characterization of PEG1500-12-acyloxy-stearate micelles and liquid crystalline phases

PEG 12-acyloxy-stearates are used as drug delivery carriers that have low cell damage effects. The mechanical and physical properties surrounding these processes and surfactants are still however not known. In this study, the physicochemical micellar properties of PEG 12-acyloxy-stearates were characterized by optical microscopic, nuclear magnetic resonance, and small-angle X-ray scattering techni

An easy-to-use method for detecting fetal hemoglobin-A test to identify bleeding from vasa previa.

Background: Vasa previa is a rare but potentially dangerous fetal condition that may occur during pregnancy. Ideally, all cases such cases are detected antenatally, but many present as late vaginal hemorrhaging. At the current time, there is no test for fetal hemoglobin (HbF) in general use. Methods: A modified method of identifying HbF is presented. Five milliliters of 0.14 M NaOH was combined wi

Association between laminin-8 and glial tumor grade, recurrence, and patient survival

BACKGROUND. The authors previously sought to identify novel markers of glioma invasion and recurrence. Their research demonstrated that brain gliomas overexpressed a subset of vascular basement components, laminins, that contained the alpha4 chain. One of these laminins, laminin-8, was found to be present in highly invasive and malignant glioblastoma multiforme (GBM) (Grade 4 astrocytoma); its exp

The effects of antiglaucoma and systemic medications on ocular blood flow

Based on the body of evidence implicating ocular blood flow disturbances in the pathogenesis of glaucoma, there is great interest in the investigation of the effects of antiglaucoma drugs and systemic medications on the various ocular vascular beds. The primary aim of this article was to review the current data available on the effects of antiglaucoma drugs and systemic medications on ocular blood

The US Examination of Nonobviousness After KSR v. Teleflex with Special Emphasis on DNA-Related Inventions

The year 2007 was an extraordinary year for the U.S. patent system. In a response to far-reaching proposals for significant changes in substantive and procedural patent law, the House of Representatives adopted the 2007 Patent Reform Act in September, heating up the debate over crucial issues that are now being discussed in the U.S. Senate.(1) Moreover, the U.S. Supreme Court also turned its atten

Study of Functional Variants of the BANK1 Gene in Rheumatoid Arthritis

Objective. To investigate 1 functional (rs17266594) and 2 potentially functional (rs10516487 and rs3733197) BANK1 variants, which were previously identified as systemic lupus erythematosus (SLE) susceptibility markers, to test whether they are associated with rheumatoid arthritis (RA). Methods. Four different cohorts were included in the study: 1,080 RA patients and 1,368 healthy controls from Spa

Upregulation of gap junction protein connexin43 in alveolar epithelial cells of rats with radiation-induced pulmonary fibrosis

The degree of immunoreactive connexin43 (C x 43) in rat lung was evaluated during the development of radiation-induced pulmonary fibrosis in rat by a double immunofluorescence technique using polyclonal antisera to Cx43 and monoclonal antibodies to cytokeratins on cryostat sections. In normal rat lungs, Cx43 was detected in pneumocytes type II and I, in large blood vessel endothelia, in peribronch

The late posterior negativity in ERP studies of episodic memory: Action monitoring and retrieval of attribute conjunctions

The focus of the present paper is a late posterior negative slow wave (LPN) that has frequently been reported in event-related potential (ERP) studies of memory. An overview of these studies suggests that two broad classes of experimental conditions tend to elicit this component: (a) item recognition tasks associated with enhanced action monitoring demands arising from response conflict and (b) me

Electroconvulsive seizures induce angiogenesis in adult rat hippocampus

Background: Electroconvulsive seizure (ECS)-treatment, a model for electroconvulsive therapy (ECT) has been shown to induce proliferation of endothelial cells in the dentate gyrus (DG) of adult rats. Here we quantified the net angiogenic response after hypoxia a known inducer of aniogenesis. Therefore we also examined the effect of oxygenation on ECS-induced proliferation of endothelial cells. Met