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Manually adjusted versus vendor-preset definition of metabolite boundaries impact on proton metabolite ratios

RATIONALE AND OBJECTIVES: Metabolite peak boundary definition is an important postprocessing step in proton magnetic resonance spectroscopy (1H-MRS). We compare metabolite ratios calculated using three different postprocessing strategies: software-rendered default peak boundaries, manually adjusted peak boundaries and a curve-fitting program. The first two of these methods are commercially availab

Compounds for deactivating phospholamban function on Ca-ATPase (phospholamban inhibitors)

This invention relates to determining the three-dimensional structure of the cytosolic domain of phospholamban (PLB) and its active site from NMR data of sufficiently high resolution for the three-dimensional structure determination. The invention also relates to methods for rational drug design enabling the design of phospholamban inhibitors based on using the three-dimensional structure data pro

Abnormalities on brain MR images during the course of familial haemophagocytic lymphohistocytosis in a child. A case report

PURPOSE: To describe and report the neuroradiological findings and clinical features in a patient with familial haemophagocytic lymphohistocytosis (FHL), a rare hereditary immune dysregulation in early childhood characterised by multisystem involvement, including in approximately 30% of cases also the central nervous system (CNS).MATERIAL AND METHODS: Serial brain MR examinations were carried out

Two-Phase Flow Analysis in a Cathode Duct of PEFCs

A three-dimensional calculation method has been further developed to include two-phase, multi-component gas and heat transport processes. A set of momentum, heat transport and gas species equations have been solved for the whole duct by coupled source terms and variable thermophysical properties. The effects of the electrochemical reactions on the heat generation and mass consumption/generation ha

Neural tolerance of the non-ionic dimers iodixanol and iotrolan and the non-ionic monomer iopamidol during myelography in non-anaesthetised rabbits

PURPOSE: The neural tolerance of the recently introduced dimer iodixanol (320 g I/l) was compared with that of the dimer iotrolan (300 g I/l) and of the monomer iopamidol (300 g I/l), both used in clinical myelography.MATERIAL AND METHODS: Non-anaesthetised rabbits were injected into the cisterna magna with Ringer's solution (control) or contrast media (CM) at doses of 1.0 or 0.5 ml/kg b.w. The be

Value of radiography in the management of possible fishbone ingestion

A retrospective study was performed on 42 consecutive patients to examine the value of radiography in the management of complaints of fishbone ingestion. All patients underwent an oral examination followed by radiographic examination with plain films, barium swallows, barium and water swallows, and an endoscopic examination. All radiographs were reviewed by two unbiased, experienced radiologists.

Elevation of the larynx on normal and abnormal cineradiogram

The relationship between bolus volume (2.5, 5, 10 and 20 ml) and larynx elevation during swallowing was assessed in 10 non-dysphagic and 10 dysphagic individuals without pharyngeal dysfunction. Laryngeal elevation in different types of pharyngeal dysfunction was assessed in 60 non-dysphagic and 75 dysphagic patients. All subjects were examined with liquid barium and cineradiography at 50 frames/s.

Relaxation dynamics of SF6 studied by energy resolved electron ion coincidence technique

The mass spectra from the SF6 molecule acquired by energy-resolved electron ion coincidence (EREICO) technique using (1t1g + [5t1u,1t2u]), (3eg + 1t2g), 4t1u, and 5a1g electrons after both valence and S 2p−1 6a1g core excitation reveal a strong selectivity in the dissociation from these states. From the comparison of the obtained spectra, the influence of the core-excited state in the relaxation p

Influence from geometrical features on the growth rate of a micro-structurally short fatigue crack

The influence on the crack growth rate on a micro-structurally short edge crack subjected to fatigue loading from changes in crack length, distance to grain boundaries and applied load has been investigated. The crack is assumed to grow in a single shear mechanism due to nucleation, glide and annihilation of dislocations along preferred slip planes in the material. The external geometry is modelle

Phospholamban inhibitors and a method for increasing coronary flow

A method for obtaining direct dilatation of the coronary arteries by administering a therapeutically effective amount of a phospholamban inhibitor is described. Compounds which are effective in relieving the inhibitory effects of phospholamban on cardiac sarcoplasmic reticulum Ca2+ -ATPase are also described.

Catechol-o-methyltransferase, polypeptide sequences and dna molecule coding therefor

A novel isolation procedure was developed that allowed the purification of rat liver and human placenta catechol-O-methyltransferase (EC 2.1.1.6, COMT) enzyme from rat and human sources to a degree sufficient to allow the amino acid sequencing of the enzyme. Recombinant clones directed against the rat liver and human placenta COMT are identified and sequenced. The isolation of pure and recombinant

One algorithm to rule them all? : An evaluation and discussion of ten eye movement event-detection algorithms

Almost all eye-movement researchers use algorithms to parse raw data and detect distinct types of eye movement events, such as fixations, saccades, and pursuit, and then base their results on these. Surprisingly, these algorithms are rarely evaluated. We evaluated the classifications of ten eye-movement event detection algorithms, on data from an SMI HiSpeed 1250 system, and compared them to manua

Conflicting Approaches to User Information Seeking Education in Scandinavian Web-Based Tutorials

The purpose of this paper is to make visible different approaches to university librarians' professional expertise such as they are mediated through user information seeking education. The empirical basis of the study consists of an analysis of 31 web-based tutorials in information literacy accessible via Scandinavian university libraries' web-sites. The results make apparent four, sometimes confl

Experimental investigation of the stability limits of premixed syngas-air flames at two moderate swirl numbers

This article presents an investigation of the swirl number effects on the stability limits of various syngas compositions in an atmospheric premixed variable-swirl burner. Lean blowout (LBO) and flashback (FB) experiments were performed using fuel mixtures containing varying amounts of H2, CO and CH4 at two swirl numbers. Reducing the swirl number from 0.66 to 0.53, reduced the flashback propensit

Role of Parental Expectations in Determining Child Labour and Schooling

The paper shows how parental expectations about child’s future income affect the incidence of child labour and schooling. We present a theoretical framework where parents decide on the optimal amount of time invested in child education in presence of uncertainty about returns to education. Here, the uncertainty is captured using the probability that parents attach to higher returns after education