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Identification of core T cell network based on immunome interactome.

Data-driven studies on the dynamics of reconstructed protein-protein interaction (PPI) networks facilitate investigation and identification of proteins important for particular processes or diseases and reduces time and costs of experimental verification. Modeling the dynamics of very large PPI networks is computationally costly.

High Critical-Current Superconductor-InAs Nanowire-Superconductor Junctions

We report on the fabrication of InAs nanowires coupled to superconducting leads with high critical current and widely tunable conductance. We implemented a double lift off nanofabrication Method to get very short nanowire devices with Ohmic contacts. We observe very high critical. currents of up to 800 nA in a wire with a diameter of 80 nm. The current- voltage characteristics of longer and suspen

Light triggered release of solutes from covalent DNA gels

DNA gels were prepared by cross-linking and were examined with respect to the release of DNA as well as macromolecular cosolutes introduced into the gels. In particular the effect of exposure to ultraviolet light was examined for these photodegradable gels. Different cross-linker densities (0.5%, 1%, 3% and 5% ethylene glycol diglycidyl ether) of the DNA gels were used. Network mesh size and the e

Anthropogenic aerosol effects on convective cloud microphysical properties in southern Sweden

In this study, we look for anthropogenic aerosol effects in southern Scandinavia's clouds under the influence of moderate levels of pollution and relatively weak dynamic forcing. This was done by comparing surface aerosol measurements with convective cloud microphysical profiles produced from satellite image analyses. The results show that the clouds associated with the anthropogenic-affected air

Dissipative particle dynamics approach for nano-scale membrane structure reconstruction and water diffusion coefficient estimation

The membrane is often considered as the heart of the proton exchange membrane fuel cell (PEMFC), and it is of pivotal importance for the involved transport phenomena and performance of the entire PEMFC. The Nafion(R) membrane is the most commonly used type of membrane in PEMFCs. In this paper, the nano-scale structure of the Nafion(R) membrane is reconstructed using dissipative particle dynamics.

How should women with pre-eclampsia be followed up? New insights from mechanistic studies

Understanding of the maternal syndrome of pre-eclampsia has greatly improved over the past 5 years. Specifically, the notion has emerged that the placenta is a source of antiangiogenic factors, such as soluble fms-like tyrosine kinase 1, that can progressively impair the mother's vascular and glomerular function throughout pregnancy. This impairment can be harmless during normal pregnancy, but in

Excessive milk production during breast-feeding prior to breast cancer diagnosis is associated with increased risk for early events.

Breast-feeding is a known protective factor against breast cancer. Breast-feeding duration is influenced by hormone levels, milk production, and lifestyle factors. The aims were to investigate how breast-feeding duration and milk production affected tumor characteristics and risk for early breast cancer events in primary breast cancer patients. Between 2002 and 2008, 634 breast cancer patients in

An experimental and theoretical core-level study of tautomerism in guanine

The core level photoemission and near edge X-ray photoabsorption spectra of guanine in the gas phase have been measured and the results interpreted with the aid of high level ab initio calculations. Tautomers are clearly identified spectroscopically, and their relative free energies and Boltzmann populations at the temperature of the experiment (600 K) have been calculated and compared with the ex

Mycophenolic Acid Exposure after Administration of Mycophenolate Mofetil in the Presence and Absence of Ciclosporin in Renal Transplant Recipients

Background and objective: The pharmacokinetics of mycophenolic acid (MPA) are complex, with large interindividual variability over time. There are also well documented interactions with ciclosporin, and assessment of MPA exposure is therefore necessary when reducing or stopping ciclosporin therapy. Here we report on the pharmacokinetic and pharmacodynamic behaviour of MPA in renal transplant patie

S’Villanorvm de Malmøghae. Landskap, urbanitet, aktörer och Malmö

The title of the article: S’Villanorum de Malmøghae, refers to an inscription on a seal from a letter written in the year of 1350, sent by the council of Malmö to their colleagues in Rostock. The motif depicts a Romanesque church flanked by the moon and a star, and the inscription states that the letter was sent on behalf of the burghers of Malmö. The seal reveals a message that Malmö should be re

Co-digestion of grease trap sludge and sewage sludge.

Redirection of organic waste, from landfilling or incineration, to biological treatment such as anaerobic digestion is of current interest in the Malmö-Copenhagen region. One type of waste that is expected to be suitable for anaerobic digestion is sludge from grease traps. Separate anaerobic digestion of this waste type and co-digestion with sewage sludge were evaluated. The methane potential was

Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes

Popular Abstract in Chinese 概括 II型糖尿病的發展趨勢在全世界範圍內非常迅速。我國目前有超過九千萬II型糖尿病患者,另外有大量血糖不正常的糖尿病高危人群。其中只有三成病人對自己的病情有所了解。II型糖尿病的病人與日俱增。 說到糖尿病,自然就會想到胰島素,以及血糖和胰島素的關系。胰島素是人體中非常重要的激素(荷爾蒙)。人體所需要的糖分主要是從食物中的澱粉類食物(米飯,面食)中來的,肉類也含有一部分的糖分。糖分從小腸吸收進入血液循環。胰島素的功能是讓身體細胞把血液中的糖分吸收進入細胞(比如肌肉細胞)加以使用,同時降低血液中的血糖成份。如果胰島素分泌不足,或者人體細胞對胰島素的敏感性降低會引起血糖升高,長期高血糖會損害血管和臟器的健康,最終導致糖尿病並發癥的發生。糖尿病並發癥是一種常見的慢性並發癥,後果相當嚴重,足部壞疽、腎功能衰竭、尿毒癥、視力模糊不清、失明、腦血Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with a multifactorial aetiology comprising of genetic and environmental factors. The common variant most highly associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the development of T2DM was unclear. Clinical, animal and in vitro studies have revealed an association of the risk T-all

Klassrummet som muntlig arena. Att bygga och etablera ethos.

Popular Abstract in Swedish Ett grundantagande för avhandlingen Klassrummet som muntlig arena. Att bygga och etablera ethos är att en människa som med trovärdighet vill kunna verka som en demokratisk medborgare i olika kommunikationssituationer måste besitta kommunikativ kompetens. Följaktligen hänger demokrati och kommunikativ kompetens tätt samman. En viktig trovärdighetsfaktor i sammanhanget ärThe Class Room as an Oral Arena: Building and Establishing Ethos starts with the premise that every person who wants to act credibly as a democratic citizen must have a communicative competence. Democracy and communicative competence are closely linked. To communicate credibly is to communicate with ethos. The purpose of this dissertation is to study how students in Swedish gymnasium build and est

Framing problems in radical innovation

The challenge of managing radical innovation is partly about dealing with higher levels of uncertainty as organisations seek to extend their exploration into new technological and market spaces. Innovation management routines for dealing with this differ from those around incremental innovation — the well-established exploit/explore dilemma. But it can be argued that there is a second challenge as