Chronic lymphocytic leukemia (CLL) is preceded by monoclonal B-cell lymphocytosis (MBL), a CLL precursor state with a prevalence of up to 12% in aged individuals; however, the duration of MBL and the mechanisms of its evolution to CLL remain largely unknown. In this study, we sequenced the B-cell receptor (BcR) immunoglobulin heavy chain (IGH) gene repertoire of 124 patients with CLL and 118 match

Cool flame has an important impact on the performance and emission of advanced low-temperature combustion (LTC) internal combustion engines (ICEs) in which the liquid fuel is injected earlier at a lower ambient temperature (Tam) than that in the conventional diesel combustion engines. However, the cool flame characteristics of spray combustion under ICEs conditions are not fully understood, e.g.,

The inorganic platinum complexes currently in clinical use for cancer treatment have severe side effects, and complexes with fewer side effects are required. One option is to use complexes that are inactive until they are light-activated. Theoretical chemistry can contribute to the design of these complexes, but most current theoretical methods lack explicit treatment of relativistic effects (sinc

Characteristic modes are formulated using the scattering dyadic, which maps incident plane waves to scattered far fields generated by an object of arbitrary material composition. Numerical construction of the scattering dyadic using arbitrary full-wave electromagnetic solvers is demonstrated in examples involving a variety of dielectric and magnetic materials. Wrapper functions for computing chara

Sodium fluoroacetate (FA) is a metabolic poison that systemically inhibits the tricarboxylic acid (TCA) cycle, causing energy deficiency and ultimately multi-organ failure. It poses a significant threat to society because of its high toxicity, potential use as a chemical weapon and lack of effective antidotal therapy. In this study, we investigated cell-permeable succinate prodrugs as potential tr

Halecania pannarica is reported for the first time in Fennoscandia from the provinces of Dalsland, Närke, Jämtland, Värmland and Västergötland in Sweden. It was found to contain pannarin rather than pannaric acid which was reported in the protologue.

Chemical conversion of carbon dioxide (CO2) into value-added products is an attractive industrial process because it offers several economic and environmental advantages. This review presents advances and challenges in the CO2 and propylene oxide (PO) co-polymerization using heterogeneous catalysts to form poly (propylene carbonate) (PPC), an environmentally friendly polymer with several applicati

The Cherenkov Telescope Array (CTA) will be the next generation very-high-energy gamma-ray observatory. CTA is expected to provide substantial improvement in accuracy and sensitivity with respect to existing instruments thanks to a tenfold increase in the number of telescopes and their state-of-the-art design. Detailed Monte Carlo simulations are used to further optimise the number of telescopes a

Joint 2D cardiac segmentation and 3D volume reconstruction are fundamental in building statistical cardiac anatomy models and understanding functional mechanisms from motion patterns. However, due to the low through-plane resolution of cine MR and high inter-subject variance, accurately segmenting cardiac images and reconstructing the 3D volume are challenging. In this study, we propose an end-to-

Background and purpose — A doubling of arthroscopic meniscal procedures was observed in Denmark from 2000 to 2011, but arthroscopic meniscal procedures for degenerative meniscal tears are no longer recommended. We performed an updated investigation of Danish meniscal procedure trends in the private and public healthcare sectors in Denmark from 2006 to 2018, including trends for other arthroscopic

This book is a collection of essays that are concerned with major figures and central topics of the history of early modern philosophy. Most of these essays are studies on the philosophy of David Hume, one of the great figures in the history of philosophy. One central theme, connecting many of the essays, concerns Hume's fundamental irreligious intentions. Russell argues that a proper appreciation

Antinuclei found in cosmic rays could provide a smoking gun signal for dark matter as this signal is virtually background free. The study of 3He cosmic rays requires the knowledge of their production, propagation in the galaxy and annihilation cross-section. While the former two have been already estimated with data-driven methods, there were no experimental data available for the 3He inelastic cr

We measured a set of π±Σ∓, π0Σ0, and π−Σ0 invariant mass spectra below and above the K¯N mass threshold in K−-induced reactions on deuteron. The measured πΣ mass spectral shape is well reproduced via the two-step mechanism, i.e., a neutron knocked out at a forward angle from a deuteron by an incident K−, with the K¯ recoiled backward reacting with the residual nucleon to produce π and Σ. We deduce

Objective: Correct diagnosis of early rheumatoid arthritis (RA) is essential for optimal treatment choices. No pathognomonic test is available, and diagnosis is based on classification criteria, which can result in misdiagnosis. Here, we examined the differences between actual and misdiagnosed RA cases in a long-term cohort of patients included based on the ACR-1987 classification criteria. Method

The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of multi-modal data makes integration and inference a non-trivial task. We developed a deep-learning-based framework, multi-omics variational autoencoders (MOVE), to integrate suc

Background: The global community has committed to achieving universal access to sexual and reproductive health and rights (SRHR) services, but how to do it remains a challenge in many low-income countries. Capacity development is listed as a means of implementation for Agenda 2030. Although it has been a major element in international development cooperation, including SRHR, its effectiveness and

The Cherenkov Telescope Array (CTA) is a next generation ground-based very-high-energy gamma-ray observatory that will allow for observations in the >10 GeV range with unprecedented photon statistics and sensitivity. This will enable the investigation of the yet-marginally explored physics of short-time-scale transient events. CTA will thus become an invaluable instrument for the study of the phys

Tenosynovial giant cell tumour (TGCT) is a rare, locally aggressive, mesenchymal tumor arising from the joints, bursa and tendon sheaths. TGCT comprises a nodular- and a diffuse-type, with the former exhibiting mostly indolent course and the latter a locally aggressive behavior. Although usually not life-threatening, TGCT may cause chronic pain and adversely impact function and quality of life (Qo