Purpose: To describe the clinical expressions, with emphasis on electrophysiological examinations, in two Swedish families with Stargardt's macular dystrophy (STGD1). Methods. Two pairs of siblings with STGD1, for whom diagnosis had been confirmed by genetic linkage to the ABCA4 gene region, were examined regarding visual acuity, kinetic perimetry, fundus photography, full-field ERG and multifocal

During 1995-97, many head nurses stated that they had perceived an increase in patients' need of nursing care. A questionnaire was designed to determine the reasons for this. The purpose of the investigation was to answer two questions, 'What were the reasons for head nurses perception of an increase in patients need of nursing care from 1995 to May 1997?' and, 'Does patient classification in the

We fabricate a single billiard, a double billiard array, and a triple billiard array by etching a GaInAs/InP heterostructure, and perform a fractal analysis of the low-temperature magneto-conductance fluctuations measured in the billiards to facilitate an empirical study of how fractals combine in a physical system. We compare our results to simulated fractal traces, and find for both experiment a

Release of glycerol and free fatty acids (FFA) was investigated in human skeletal muscle strips. In the basal state, glycerol and FFA were released at almost equimolar rates (0.3 nmol/ng tissue.90 min). A nonselective beta-adrenoceptor agonist, isoprenaline, caused a concentration-dependent stimulation of glycerol release, whereas FFA release was unaffected. Basal and isoprenaline-induced glycerol

The determination of accurate and precise ages for the timing of collision between oceanic plateaus and continental crust requires an understanding of how the indenting and buttressing plates respond to the collision. We present geochronological, thermochronological, geochemical and isotopic analyses of magmatic rocks from the Ecuadorian Andes, which relate to the collision of the Late Cretaceous

Analys av den svartlistade Abraham Polonskys arbeta som manusförfattare och regissör inom amerikansk kriminalfilm på 1940- och 1950-talen, film noir.

Tens of thousands of man-made chemicals are in regular use and discharged into the environment. Many of them are known to interfere with the hormonal systems in humans and wildlife. Given the complexity of endocrine systems, there are many ways in which endocrine-disrupting chemicals (EDCs) can affect the body's signaling system, and this makes unraveling the mechanisms of action of these chemical

The homolytic Co-C bond dissociation energy (BDE) is central to the understanding of the function of vitamin B12, an important coenzyme of many proteins. We investigate why earlier density functional (B3LYP) estimations of the BDE in methylcobalamin have given so poor results (91-117 kJ/mol) compared to the experimental estimate (155 ± 13 kJ/mol). Improving the basis set increases the discrepancy,

Intracellular lipolysis is a major pathway of lipid metabolism that has roles, not only in the provision of free fatty acids as energy substrate, but also in intracellular signal transduction. The latter is likely to be particularly important in the regulation of insulin secretion from islet beta-cells. The mechanisms by which lipolysis is regulated in different tissues is, therefore, of considera

Exit of recycling cholesterol from late endosomes is defective in Niemann-Pick C1 (NPC1) and Niemann-Pick C2 (NPC2) diseases. The traffic route of the recycling proteoglycan glypican-1 (Gpc-1) may also involve late endosomes and could thus be affected in these diseases. During recycling through intracellular compartments, the heparan sulfate (HS) side chains of Gpc-1 are deaminatively degraded by

Popular Abstract in Swedish "Varje text hur utan värde än / blir lysande som död och sol och stränder, / när jag spelar er förväntan, / detta ojämförligt rika instrument" Så säger Harlequin till sin publik i Paul Anderssons Berättarna från 1955. Spelar med publikens förväntan gör också diktverkets upphovsman. I diktens spegel iscensätts den författargestalt som hade blivit ett fenomen i den litteBeing one of the central poets in the Swedish neo-Romantic movement of the early 1950's, Paul Andersson (1930-1976) was surrounded by a bright authorial aura even before he published his first poems at the age of 21. In 1953, Andersson's reputation became nationwide when the influential poet and critic Karl Vennberg declared him to be a genius. Three years later, Andersson had published his last b

A manikin test probe has been developed to simulate the thermal behaviour of human skin when exposed to thermal conditions likely to occur in fires. The threshold for second-degree burn injuries is evaluated from the temperature readings using a damage integral. The probe has been exposed to different radiation fluxes and the calculated damage criterion for second-degree burn injuries is in agreem

We present a complete Monte Carlo simulation of the transport properties of a Si/SiGe quantum well. The scattering mechanisms, viz. intervalley phonons, acoustic phonons, interface roughness and impurity scattering (including resonant scattering), are considered in detail, and we derive analytic expressions for the scattering rates, in each case properly taking the quantized electron wave function

Doppler shift attenuation lifetime measurements have been carried out for the 3qp and isomeric rotational bands in Y-83 using the reaction (Ni(Si,3p))-Ni-58-Si-28. While the transitional quadrupole moments in the 3qp bands are slightly lower than in the 1 qp bands, we found evidence for a strong reduction in \Q(t)\ for the isomeric band.

Artikeln är en populärvetenskapligt orienterad presentation av forskningsprojektet med samma namn.

An experiment utilizing a double fragmentation reaction was performed to study isobaric analogue states in A similar to 50 nuclei approaching the proton drip-line. gamma-ray spectroscopy will be used to identify excited states in the neutron-deficient nuclei produced in the second fragmentation reaction. Excited state level schemes will be obtained, through comparison with states in their well-kno