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An engineered combinatorial module of transcription factors boosts production of monoterpenoid indole alkaloids in Catharanthus roseus

To fend off microbial pathogens and herbivores, plants have evolved a wide range of defense strategies such as physical barriers, or the production of anti-digestive proteins or bioactive specialized metabolites. Accumulation of the latter compounds is often regulated by transcriptional activation of the biosynthesis pathway genes by the phytohormone jasmonate-isoleucine. Here, we used our recentl

Patterns and Drivers of Regional Crop Production in Chad

Jordbruk utgör den största ekonomiska sektorn och har den högsta sysselsättningsgraden i Tchad. Samtidigt så genomgår den hastiga förändringar på grund av populationsökning, institutionella reformer, konflikter i grannländerna, ökande globaliserade handelsnätverk, samt miljöförändringar. Men trots dess betydelse för lokala uppehällen och ekonomisk tillväxt, så är de specifika förändringsmönstrena Agriculture constitutes the largest economic sector and professional occupation in Chad, and is undergoing rapid changes due to processes of population increase, institutional reforms, conflicts in neighbouring countries, increasingly globalized trade networks, and environmental changes. But despite their importance for livelihoods and economic growth, the specific patterns and drivers of change i

The peer context of dieting : The relationship between young adults’ dieting frequency and their friends’ weight-related characteristics

Previous research found that weight-related behaviors and body weight tends to be similar between individuals and peers. Rather little is known how different domains of weight-related behaviors co-evolve in peer networks. Hence, this study explores how young adults’ self-reported dieting relates to perceived body weight and weight control behaviors of their peers. A Swedish two-wave panel survey w

Comprehensive comparison between APOGEE and LAMOST : Radial velocities and atmospheric stellar parameters

Context. In the era of massive spectroscopy surveys, automated stellar parameter pipelines and their validation are extremely important for an efficient scientific exploitation of the spectra. Aims. We undertake a critical and comprehensive comparison of the radial velocities and the main stellar atmosphere parameters for stars in common between the latest data releases from the Apache Point Obser

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent

Operation and performance of the ATLAS Tile Calorimeter in Run 1

The Tile Calorimeter is the hadron calorimeter covering the central region of the ATLAS experiment at the Large Hadron Collider. Approximately 10,000 photomultipliers collect light from scintillating tiles acting as the active material sandwiched between slabs of steel absorber. This paper gives an overview of the calorimeter’s performance during the years 2008–2012 using cosmic-ray muon events an

Armeniens »sammetsrevolution» 2018 och varför den dröjde så länge

In early April 2018 Armenia completed the transition from semi-presidential rule to a parliamentary republic. Under the slogan ‘More power to the people’, the ruling Republican Party had paved the way for the incumbent president, Serzh Sargsyan, to continue in power, now as prime minister as his second and final term of presidency was drawing to an end. However, the ensuing events ended with popul

Phonon-induced linewidths of graphene electronic states

The linewidths of the π and σ bands originating from the electron-phonon coupling in graphene are analyzed based on model calculations and experimental angle-resolved photoemission spectroscopy (ARPES) data. We find evidence for crucial contributions to the lifetime broadening from interband scattering π→σ and σ→π, respectively, driven by the out-of-plane ZA acoustic phonons. The essential feature

Pseudorapidity Dependence of Particle Production and Elliptic Flow in Asymmetric Nuclear Collisions of p+Al, p+Au, d+Au, and 3He+Au at √sNN=200 GeV

Asymmetric nuclear collisions of p+Al, p+Au, d+Au, and 3He+Au at √sNN=200 GeV provide an excellent laboratory for understanding particle production, as well as exploring interactions among these particles after their initial creation in the collision. We present measurements of charged hadron production dNch/dη in all such collision systems over a broad pseudorapidity range and as a function of co

Mitotic activity and survival in advanced non-Hodgkin's lymphoma of unfavourable histology

The number of mitoses per high power field (mitotic index, MI) was assessed in 2 νm sections of lymph node biopsies from 58 adults with non-Hodgkin's lymphoma. All had diffuse nodal lymphomas of unfavourable histology and stage II-IV disease. The patients were treated with chemotherapy and followed for a minimum of 3 years or until death. None out of 29 patients with a MI ≥ 3.0 survived for 3 year

Multiple interferon regulatory factor and NF-κB sites cooperate in mediating cell-type- and maturation-specific activation of the human CD83 promoter in dendritic cells

CD83 is one of the best-known surface markers for fully mature dendritic cells (mature DCs), and its cell-type- and maturation-specific regulation makes the CD83 promoter an interesting tool for the genetic modulation of DCs. To determine the mechanisms regulating this DC- and maturation-specific CD83 expression, chromatin immunoprecipitation (ChIP)-on-chip microarray, biocomputational, reporter,

Late age at first full-term pregnancy as a risk factor for women with malignant lymphoma

Women with malignant lymphoma, non-Hodgkin's lymphoma and Hodgkin's disease were of a significantly later age at first full-term pregnancy (AFFP) than controls without malignant disorders. The odds ratio (OR) of having the first pregnancy at 30 years of fertility was 6.4 for women with malignant lymphoma. This ratio was higher than the ratio of 3.9 in a group of breast cancer patients. A low parit

Software-based data acquisition and processing for neutron detectors at European Spallation Source - Early experience from four detector designs

European Spallation Source (ESS) will deliver neutrons at high flux for use in diverse neutron scattering techniques. The neutron source facility and the scientific instruments will be located in Lund, and the Data Management and Software Centre (DMSC), in Copenhagen. A number of detector prototypes are being developed at ESS together with its European in-kind partners, for example: SoNDe, Multi-G

Heat production rate in blood lymphocytes as a prognostic factor in non‐Hodgkin's lymphoma

Abstract: The heat production rate in peripheral blood lymphocytes was evaluated by direct calorimetry in 76 untreated adults with non‐Hodgkin's lymphoma (NHL). Elevated values were recorded for 20 out of 54 patients with lymphomas of high or intermediate malignancy grade (37%) and for 1 out of 22 patients (5%) with low grade lymphomas (p = 0.01). Median survival was 39 months for patients with no

Country of ownership change in the premium segment : consequences for brand image

Purpose: This paper aims to explore how the ownership transfer from a highly industrialised country to less industrialised countries influences consumers’ brand perceptions. Design/methodology/approach: Three acquisition cases of premium car brands (Jaguar, Land Rover and Volvo) are investigated using qualitative data from online brand communities. Findings: When country of ownership (COOW) for br

Rising incidence of breast cancer among young women in Sweden

The national Swedish cancer registry was used to analyse the age-specific time trends in breast cancer incidence in Sweden from 1970 to 1984. The analysis included both a calendar year and a birth cohort approach to estimate time trends in disease occurrence. According to the birth cohort approach there was a statistically significant increase in the incidence with an average annual increase of th

Deletion of 14q in non‐Hodgkin's lymphoma

Abstract: 6 patients with non‐Hodgkin's lymphoma [3 with small cell lymphocytic lymphoma of B‐cell type (SL), and 1 each with follicular centroblastic/centrocytic, centroblastic, and immunoblastic lymphoma] and with the acquired cytogenetic abnormalities del(14) (q22) or del(14) (q24) are described. An evaluation of these 6 cases and 41 other lymphatic neoplasms with 14q deletion known from the li