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Previous evidence has shown that stromal cell-derived inducing activity (SDIA), produced by the mouse PA6 stromal cell line, promotes dopaminergic differentiation of mouse, monkey and human embryonic stem cells in vitro. To examine whether PA6 stromal cells can enhance the yield of dopaminergic differentiation from neural progenitors, we generated neurospheres from embryonic day 11.5 (E11.5) (midb
Mitt paper handlar om den amerikanska tv-serien Six Feet Under, och i fokus för min framställning står berättelsens behandling av föreställningar om döden som knuten till naturen och som något ”naturligt” – satt i relation till kultur och estetik. I Six Feet Under behandlas en rad ämnen centrala för det västerländska samhällets diskurser om natur, kultur, moral och existens. Serien fick ett stort
Birds and bats have evolved powered flight independently, which makes a comparison of evolutionary 'design' solutions potentially interesting. In this paper we highlight similarities and differences with respect to flight characteristics, including morphology, flight kinematics, aerodynamics, energetics and flight performance. Birds' size range is 0.002-15 kg and bats' size range is 0.002-1.5 kg.
Lymphomas are one of the few cancers that have been increasing in incidence over the past decades. So far, only a few established risk factors have been identified, including immunosuppression and viral infections. Recent evidence suggests etiologic heterogeneity of different lymphoma subtypes. Smoking may affect risk differently, depending on the lymphoma entity. The European Prospective Investig
Bacterial and viral abundances were measured in 24 lakes with dissolved organic carbon (DOC) concentrations ranging from 3 to 19 mg of C liter(-1). In addition, a laboratory experiment was performed to test the effects of different sources of carbon (i.e., glucose and fulvic acids) and nutrients on the dynamics of viruses and bacteria. In the lake survey, no correlation was found between virus abu
The antiproliferative activity of the 14 isomeric monoxylosylated dihydroxynaphthalenes has been tested in vitro toward normal HFL-1 and 3T3 A31 cells as well as transformed T24 and 3T3 SV40 cells. The antiproliferative effect toward HFL-1 cells was correlated with the polarity of the compounds. However, in the case of transformed T24 cells, some compounds showed a clearly different behavior resul
Individual forager behaviors should affect per capita intake rates and thereby population and consumer-resource properties. We consider and incorporate conspecific facilitation and interference during the separate foraging-cycle stages in a functional response model that links individual behavioral interactions with consumer-resource processes. Our analyses suggest that failing to properly conside
Kaposi's sarcoma-associated herpesvirus (KSHV) is closely associated with Kaposi's sarcoma and certain B-cell lymphomas. The fourth open reading frame of the KSHV genome encodes a protein (KSHV complement control protein (KCP, previously termed ORF4)) predicted to have complement-regulating activity. Here, we show that soluble KCP strongly enhanced the decay of classical C3-convertase but not the
In order to improve the understanding of food-web interactions in sub-Antarctic freshwater systems, we complemented earlier experimental studies with analyses of differences in stable isotopes (N-15 and C-13) among organisms in two lakes with contrasting productivity. The distribution of the stable isotopes showed that the small copepod Boeckella michaelseni feeds mainly on pelagic POM (particulat
The moderate halophile Halomonas boliviensis, isolated from a Bolivian saline soil sample, was able to accumulate poly(P-hydroxybutyrate) (PHB) when grown under conditions of nutrient limitation and excess carbon source. The concentration of sodium chloride in the medium influenced the cell-growth, -size, and rate of PHB accumulation. Cultivation in shake flasks led to a PHB accumulation of about
Candida albicans, an important pathogenic yeast, activates all three pathways of the complement system. To understand how this yeast evades the effects of the activated system, we have analyzed the binding of the classical pathway inhibitor C4b-binding protein (C4BP) by C. albicans. Purified native as well as recombinant C4BP bound dose dependently to the yeast and hyphal forms, as shown by multip
Evidence from sedimentology and conodont biostratigraphy is used to reinterpret the mid-Homerian (Late Wenlock) succession on Gotland, Sweden. A new conodont zonation includes from below: the Ozarkodina bohemica longa Zone (including five subzones), the Kockelella ortus absidata Zone and the Ctenognathodus murchisoni Zone (two taxa are named, Ozarkodina bohemica longa and Pseudooneotodus linguicor
We report on the design and fabrication of a channel structure for high precision guidance and achieving excellent confinement properties for motor-propelled molecular shuttles. The techniques used to manufacture the channel structure are mainly e-beam lithography and selective monolayer functionalization. The structure consists of two lateral layers of concentric channels on a SiO2 surface made b
We reviewed the literature on urothelial carcinoma in the prostatic urethra and prostate. We concluded that the incidence of urothelial carcinoma in the prostatic urethra and prostate is probably underestimated. This fact warrants thorough follow-up of patients with high-risk bladder cancers and also whole-mount examination of the prostate after cystectomy to recognize the true incidence and exten
The identification of novel tumour-associated antigens (TAAs) is pivotal for progression in the fields of tumour immunotherapy and diagnosis. In the present study, we have developed, based on flow cytometric evaluation and use of a mini-library composed of specific antibody clones linked to different antibiotic resistance markers, methods for positive and subtractive selection of phage antibodies
We characterize attosecond pulses in a train using both the well established "reconstruction of attosecond beating by interference of two-photon transitions" (RABITT) technique and the recently demonstrated in situ method, which is based on a weak perturbation of the harmonic generation process by the second harmonic of the laser field. The latter technique determines the characteristics of the si
This article is based upon "The management of diabetic foot osteomyelitis - a progress report on diagnosing and a consensus on treating osteomyelitis". The principle of treatment is to administer antibiotics while providing a local environment in which the medication can work. This typically involves the removal of dead, soft tissue and accessible dead bone during the wound care process. These int
We have investigated the possibility of using carbon nanotubes as flexible, mobile electrical probes able to electrically contact nanometre- scaled objects. Configurations with metal electrodes evaporated on top of multi-, few- and single-wall carbon nanotubes have been studied. Scanning probe manipulation was used to create nano-mechanical switches by first cutting the various tubes, and then mov
