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Researchers from Lund University in Sweden have identified a new layer of gene regulation mediated by changes in ribonucleic acid metabolism downstream of major oncogenes. This study, published now in the Molecular Cell journal, explains aggressive clinical features observed in triple negative breast cancers. A collaborative study between Lund Stem Cell Center (LSCC) and Lund University Cancer Cen
During her PhD studies Shelby Shrigley has been exploring patient-specific cell replacement therapy for Parkinson's disease. Defending her PhD thesis on March 12th, here Shelby tells us about her research within the Developmental and Regenerative Neurobiology research group led by Prof. Malin Parmar and her time spent at Lund Stem Cell Center. Can you tell us about your PhD research? The main focu
https://www.stemcellcenter.lu.se/article/phd-defence-interview-shelby-shrigley - 2026-01-01
In recent years, therapeutic antibodies have transformed the treatment of cancer and autoimmune diseases. Now, researchers at Lund University in Sweden have developed a new, efficient method based on the genetic scissors CRISPR-Cas9, that facilitates antibody development. The discovery is published in Nature Communications. Antibody drugs are the fastest growing class of drug, and several therapeu
https://www.stemcellcenter.lu.se/article/new-method-developing-antibody-based-drugs - 2026-01-01
The fight against COVID-19 continues. In Lund, researchers are working to identify a compound that could be used to prevent viral infection, and thus save lives. “This model that has been developed with our collaborators will fill an important gap for current and future drug screening efforts for the upper or lower airways using human airway cells”, says Sinem Tas, associate researcher. The most r
https://www.stemcellcenter.lu.se/article/new-model-human-airways-speeds-battle-against-covid-19 - 2026-01-01
The Chinese National Twin Registry (CNTR) currently includes data from 61 566 twin pair from 11 provinces or cities in China. Of these, 31 705, 15 060 and 13 531 pairs are monozygotic, same‐sex dizygotic and opposite‐sex dizygotic pairs, respectively, determined by opposite sex or intrapair similarity. Read more here.
https://www.lupop.lu.se/article/chinese-national-twin-registry-gold-mine-scientific-research - 2026-01-01
Application to epidemiological record data in a large-scale biobank (Tohoku Medical Megabank Organization, Japan) shows that a combination of kurPCA and RAMP effectively detects known errors or inconsistent patterns. Read more here.
https://www.lupop.lu.se/article/outlier-detection-questionnaire-data-biobanks - 2026-01-01
Socioeconomic status has a negative impact on swimming ability in Swedish children, a new BlueHealth study has found. Read more here.
https://www.lupop.lu.se/article/new-study-highlights-disparity-swimming-skills - 2026-01-01
A pan-European enterprise to provide a catalogue (https://bio.tools) of tools and databases that can be used in these workflows. bio.tools not only lists where to find resources, but also provides a wide variety of practical information. Read more here.
https://www.lupop.lu.se/article/biotools-registry-software-tools-and-data-resources-life-sciences - 2026-01-01
This Glossary, rooted primarily in the Canadian context but drawing on lessons from elsewhere, describes environmental public health regulatory practice in relation to health equity, including approaches that practitioners can use to contribute to addressing the social determinants of health. Read more here.
https://www.lupop.lu.se/article/glossary-health-equity-context-environmental-public-health-practice - 2026-01-01
Mediation analysis is a powerful tool for understanding mechanisms, but conclusions about direct and indirect effects will be invalid if there is unmeasured confounding of the mediator–outcome relationship. Read more here.
https://www.lupop.lu.se/article/approximate-sensitivity-analysis-unmeasured-mediator-outcome-confounding - 2026-01-01
Over the past decade, several large registries of patients with idiopathic pulmonary fibrosis (IPF) have been established. These registries are collecting a wealth of longitudinal data on thousands of patients with this rare disease. The data collected in these registries will be complementary to data collected in clinical trials because the patient populations studied in registries have a broader
https://www.lupop.lu.se/article/patient-registries-idiopathic-pulmonary-fibrosis - 2026-01-01
The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and a unique research platform and network to obtain substantial knowledge about several important risk and prognostic factors in major chronic diseases. A random sample of 45,000 participants between 45 and 74 years of age from the general population of Hamburg, Germany, are taking part in an ex
https://www.lupop.lu.se/article/rationale-and-design-hamburg-city-health-study - 2026-01-01
Surgical quality registries are important tools for both performing research and improving clinical practice. The Swedish National Knee Ligament Registry (SNKLR) has collected patient-reported and surgical data on more than 90% of the anterior cruciate ligament (ACL) reconstructions in Sweden. There has year-by-year been an increasing number of publications using data from SNKLR and the Scandinavi
Self-selection into prospective cohort studies and loss to follow-up can cause biased exposure-outcome association estimates. Previous investigations illustrated that such biases can be small in large prospective cohort studies. The structural approach to selection bias shows that general statements about bias are not possible for studies that investigate multiple exposures and outcomes, and that
https://www.lupop.lu.se/article/bias-self-selection-and-loss-follow-prospective-cohort-studies - 2026-01-01
Comorbidity in stroke is common, but comprehensive reports are sparse. We describe prevalence of comorbidity and the prognostic impact on mortality and functional outcome in a large national ischemic stroke cohort. New publication in SAGE Journals
Multiple asthma patient registries have been established globally to provide valuable information on current clinical management, including treatment patterns, adherence, and the long-term outcomes that are important to patients, providers, and other decision makers. New publication in Immunology
https://www.lupop.lu.se/article/step-right-direction-harmonizing-measures-use-asthma-patient-registries - 2026-01-01
An increasing number of patients with central nervous system (CNS) tumor could survive to reproductive age. However, it is largely unknown whether the history of CNS tumor might affect pregnancy outcome. We aimed to explore the risk of being born preterm among children of CNS tumor survivors. New publication in International Journal of Cancer
To inform evidence-based practice in health care, guidelines and policies require accurate identification, collation, and integration of all available evidence in a comprehensive, meaningful, and time-efficient manner. Approaches to evidence synthesis such as carefully conducted systematic reviews and meta-analyses are essential tools to summarize specific topics. Unfortunately, not all systematic
Nu finns ett nytt nyhetsbrev från SND att läsa online, med bland annat ledare av Monica Lassi vid LU. Läs nyhetsbrevet här.
https://www.lupop.lu.se/article/natverksnytt-fran-snd - 2026-01-01
The European Society of cardiology (ESC) EURObservational Research Programme (EORP) Chronic Ischemic Cardiovascular Disease registry Long Term (CICD) aims to study the clinical profile, treatment modalities and outcomes of patients diagnosed with CICD in a contemporary environment in order to assess whether these patients at high cardiovascular risk are treated according to ESC guidelines on preve
