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There are a few studies that report cognitive impairment as a complication of treatment with beta- blockers. We aimed to evaluate the longitudinal association between use of beta-blockers, as a class, and incident risk of all-cause dementia, vascular dementia, Alzheimer's and mixed dementia in the prospective population-based Malmö Preventive Project. We included 18,063 individuals (mean age 68.2,

https://www.lupop.lu.se/article/beta-blocker-therapy-and-risk-vascular-dementia-population-based-prospective-study - 2025-12-29

Preeclampsia (PE) is a common pregnancy-related disorder associated with cardiovascular long-term disease. Eighty percent are late-onset PE, occurring after 34 gestational weeks, and can present with severe symptoms. Magnitude and reversibility rate of maternal cardiovascular changes after severe late-onset PE have not been characterized. This study therefore evaluated longitudinal dynamics of mat

https://www.lupop.lu.se/article/cardiovascular-effects-severe-late-onset-preeclampsia-are-reversed-within-six-months-postpartum - 2025-12-29

Ovarian cancer (OC) is usually detected in late clinical stages, and imaging at diagnosis is crucial. Peritoneal carcinomatosis (PC) and cardio phrenic lymph nodes (CPLN) are pathological findings of computed tomography (CT) and are relevant for surgical planning. Furthermore, mammographic breast density (BD) has shown an association with OC risk and might be prognostically relevant. However, it i

https://www.lupop.lu.se/article/ovarian-cancer-subtypes-and-survival-relation-three-comprehensive-imaging-parameters - 2025-12-29

The discrepancy between social and biological clock due to sleep and wake up time difference across weekdays and weekends is referred as social jetlag. The overall aim of this study is to test whether there is an association between both screen time and nighttime texting and social jetlag among 13- to 15-year-old adolescents in Sweden. This study included a cross-sectional survey in which data wer

https://www.lupop.lu.se/article/social-jetlag-and-its-association-screen-time-and-nighttime-texting-among-adolescents-sweden-cross - 2025-12-29

The study population included all adults with diagnosed AF (n = 156,104) aged ≥ 45 years in Sweden without an earlier recorded diagnosis of dementia. Individuals with a dispensed prescription of levothyroxine on two or more occasions between July 1 2005 and December 31 2006 in Sweden were considered exposed (n = 12,978; 8.3%), and were compared to all other patients with AF without this treatment.

https://www.lupop.lu.se/article/levothyroxine-treatment-and-incident-dementia-adults-atrial-fibrillation - 2025-12-29

Winner of the Poster Session at RDA (Research Data Alliance) Virtual Plenary Meeting! Read more, and see the poster at https://www.rd-alliance.org/missing-data-relationship-between-legal-req…!

https://www.lupop.lu.se/article/missing-data-relationship-between-legal-requirements-and-open-research-data - 2025-12-29

LUPOP is running a matchmaking initiative, connecting clinically active researchers with non-clinicians who are willing to help out with research during the corona-pandemic. Today, the team of researchers who are willing to help can provide expertise in these areasAgeingBioinformaticsBiology (molecular, computational)BiomarkersCardiometabolic risksData management (data mining, data compilation, da

https://www.lupop.lu.se/article/do-you-need-help-your-research-while-working-covid-19-patients - 2025-12-29

Loss to follow-up in dementia studies is common and related to cognition, which worsens over time. We aimed to describe dropout and missing cognitive data in the Swedish dementia registry, SveDem; identify factors associated with dropout; and estimate propensity scores and use them to adjust for dropout. New publication in Alzheimers Dement

https://www.lupop.lu.se/article/controlling-selective-dropout-longitudinal-dementia-data-application-svedem-registry - 2025-12-29

Male hypogonadism is associated with higher risk of co-morbidity and premature mortality. It is, therefore, of utmost importance to identify young men who are at the highest risk of testosterone deficiency and who may benefit from preventive measures. In this context, infertile men constitute a high-risk group. The extent of testosterone replacement therapy (TRT) among infertile men, defined as me

https://www.lupop.lu.se/article/testosterone-replacement-therapy-men-who-conceived-intracytoplasmic-sperm-injection-nationwide - 2025-12-29

C-reactive protein (CRP) is not included in the major intensive care unit (ICU) prognostic tools such as the Simplified Acute Physiology Score (SAPS). We assessed CRP on ICU admission as a SAPS-3 independent risk marker for short-term mortality and length of stay (LOS) in ICU patients with sepsis. New publication in Journal of Critical Care

https://www.lupop.lu.se/article/c-reactive-protein-prognostic-factor-intensive-care-admissions-sepsis-swedish-multicenter-study - 2025-12-29

The cognitive components of subjective well-being can be measured with the Satisfaction with life scale (SWLS) and the Harmony in life scale (HILS), which both comprise five items each. The aim of this article is to abbreviate these scales and examine their psychometric properties and validity. Three datasets including test-retest data are used (N = 787; N = 860; N = 343). New publication in Journ

https://www.lupop.lu.se/article/abbreviated-three-item-versions-satisfaction-life-scale-and-harmony-life-scale-yield-strong - 2025-12-29

The West Sweden Asthma Study (WSAS) is a population-representative longitudinal study established to: generate data on prevalence trends, incidence and remission of asthma, allergy and respiratory conditions, elucidate on the risk and prognostic factors associated with these diseases, characterise clinically relevant phenotypes of these diseases and catalyse relevant mechanistic, genomic, genetic

https://www.lupop.lu.se/article/cohort-profile-west-sweden-asthma-study-wsas-multidisciplinary-population-based-longitudinal-study - 2025-12-29

Treatment options for peritoneal metastases (PM) from colorectal cancer (CRC) have increased, their efficiency should be monitored. For this purpose, register-based data on PM can be used, if valid. Purpose: We aimed to evaluate the completeness and positive predictive value (PPV) of synchronous peritoneal metastases (S-PM) registered among CRC patients in the Danish National Patient Register (DNP

https://www.lupop.lu.se/article/validity-registered-synchronous-peritoneal-metastases-colorectal-cancer-danish-medical-registries - 2025-12-29

Carotid-femoral pulse wave velocity (cfPWV) and its risk factors may differ between various populations. Few studies have compared the risk profiles associated with cfPWV in different ethnic populations. The study population included 4321 subjects from Shanghai, China (n = 1272, age 75.0 ± 6.5 years, female 57.3%) and Malmö, Sweden (n = 3049, age 72.5 ± 5.5 years, female 60.4%). cfPWV was measured

https://www.lupop.lu.se/article/difference-risk-profiles-carotid-femoral-pulse-wave-velocity-results-two-community-based-studies - 2025-12-29

The Systemic Anti-Cancer Therapy (SACT) database is a population-based resource of SACT activity reported routinely by National Health Service (NHS) trusts in England. Data are collected on the SACT treatments of adult and paediatric patients, delivered in secondary and tertiary settings with the intention of improving survival, delaying further cancer progression or development and improving dise

https://www.lupop.lu.se/article/data-resource-profile-systemic-anti-cancer-therapy-sact-dataset - 2025-12-29

Statusrapport i Vetenskapsrådets uppdrag – summering av arbetet 2017–2019 och fortsatt arbete Läs mer här.

https://www.lupop.lu.se/article/samordning-av-oppen-tillgang-till-forskningsdata - 2025-12-29

There are limited data regarding efficacy of abatacept treatment for rheumatoid arthritis (RA) outside clinical trials. Quality registers have been useful for observational studies on tumor necrosis factor inhibition in clinical practice. The aim of this study was to investigate clinical efficacy and tolerability of abatacept in RA, using a national register. New publication in BMC Arthritis Resea

https://www.lupop.lu.se/article/abatacept-rheumatoid-arthritis-survival-drug-clinical-outcomes-and-their-predictors-data-large - 2025-12-29

The National Cancer Registration and Analysis Service (NCRAS), part of Public Health England (PHE), is the population-based cancer registry for England. It collects, quality assures and analyses data on all people living in England who are diagnosed with malignant and pre-malignant neoplasms, with national coverage since 1971. It produces the national cancer registration dataset for England. The p

https://www.lupop.lu.se/article/data-resource-profile-national-cancer-registration-dataset-england - 2025-12-29

Lecturer: Tyler J. VanderWeele, Ph.D., Professor of Epidemiology in the Departments of Epidemiology and Biostatistics at the Harvard T.H. Chan School of Public, Boston, MA, USA Find more information here.

https://www.lupop.lu.se/article/workshop-causal-mediation-and-interaction-analysis - 2025-12-29

A circumferential resection margin (CRM) of 1·0 mm or less after rectal cancer surgery is thought to increase the risk of local recurrence (LR). This retrospective population‐based study examined how CRM distance affects the LR risk. New publication in BJS Society

https://www.lupop.lu.se/article/risk-local-recurrence-rectal-cancer-and-circumferential-resection-margin-population-based-cohort - 2025-12-29