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PURPOSE: Direct Saturation Dynamic Glucose Enhanced (DS-DGE) MRI is a novel technique that utilizes low B 1 strength and short saturation pulse duration to measure the effect of enhanced T 2 relaxation caused by the infusion of D-glucose, resulting in linewidth broadening of the direct water saturation (DS) signal in the water saturation spectrum (Z-spectrum). In this simulation-supported protoc
INTRODUCTION: Treatment response in high grade gliomas (HGG) is influenced by O6-methylguanine-DNA methyltransferase promoter methylation (MGMTpm). Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) is a non-invasive approach for potential molecular tumor characterization, although previous studies have reported inconsistent results for MGMTpm. This study investigates fl
Using nationwide register data, individuals aged 15–60 years registered as suspects of firearm homicide, attempted firearm homicide, or conspiracy/preparation to commit such offenses (firearm homicide+) between 2000 and 2020 were matched to population controls. Conditional logistic regression examined the association between immigrant background and registered suspicion of firearm homicide+, adjus
PURPOSE: Patients with the traditional definition of multimorbidity, with 2 or more chronic diseases, are a very large and heterogeneous group who differ considerably depending on which set of disorders they suffer from. This paper describes the baselines characteristics of the GerMoT cohort and investigates if the GerMoT inclusion criteria could be used to identify a subgroup of multimorbid patie
INTRODUCTION: Although there are more women than men working in the healthcare system in Europe, reports of gender-related inequities within the healthcare workforce are still emerging. Our study aimed to gather insights from women, representing different healthcare professions, who work in the field of geriatric medicine and gerontology, to better understand their perspectives and experiences.MET
Medan opinionsmätningarna duggade tätt låg en annan fråga och skvalpade under ytan i valrörelsen: om framtiden för AI-bolagen och hur datacenter ska byggas och förses med el i det svenska landskapet. Här finns en skiljelinje som kan ha påverkat valutgången och kommer göra det framöver.
En av valrörelsens stora snackisar var om Liberalerna skulle klara spärren. Mycket tyder på att L åtnjöt en lika strid ström av taktiska röster från Moderatsympatisörer som Kristdemokraterna gjorde vid valet 2010.
Gene therapy with AAV vectors carrying genes for neuropeptide Y and its receptor Y2 has been shown to inhibit seizures in multiple animal models of epilepsy. It is however unknown how the AAV serotype or the sequence order of these two transgenes in the expression cassette affects the actual parenchymal gene expression levels and the seizure-suppressant efficacy. To address these questions, we com
Epilepsy is a central nervous system disorder causing uncontrollable seizures. One-third of patients do not respond to current medications, necessitating new treatments. This study targeted epileptogenesis, the process leading to chronic epilepsy, using human mesenchymal stem cells (MSCs) in a rodent model. MSC transplantation can positively affect neurodegenerative diseases by modifying inflammat
Bacteria deploy virulence factors to subvert host immunity; yet the molecular details of these interactions often remain limited. Here, we reveal the structure and host interactome of the Streptococcus pyogenes nuclease A (SpnA). We characterize the structure and dynamics of SpnA using hydrogen-deuterium exchange mass spectrometry and single-particle electron cryo microscopy, yielding the first st
Educational change is not simply a matter of reform. The political project of changing education may itself turn education into a site of struggle over what education should be, what kinds of human beings – and, by extension, what kind of society – it is expected to produce, and what futures it should make possible. This thesis explores the Iranian state’s policy project of changing education afte
Climate change represents a major threat to global biodiversity and associated ecosystem functions, including pollination. In both natural and agricultural environments, semi-natural grasslands represent crucial foraging and nesting habitats for wild pollinators such as bumblebees, for which temporal population trends in these habitats remain understudied. Here, we use data from a large-scale syst
Background – Trastuzumab deruxtecan (T-DXd) is effective in HER2-expressing metastatic breast cancer (mBC), yet inter-patient benefit varies. The current reference biomarker—HER2 immunohistochemistry (IHC) on tumor biopsies—is insufficient as a sole predictor of response. HER2-targeted PET/CT offers non-invasive, whole-body, real-time assessment of target expression. We hypothesize that HER2-targe
The use of ground-source heat pump systems for heating and cooling of buildings is becoming increasingly widespread throughout the world. The most common application of ground-source heating and cooling systems uses vertical boreholes. The primary function of a ground heat exchanger is to efficiently transfer heat between the ground and an above-ground heating and/or cooling load. The heat transfe
Twenty-five years ago, the book The Ecology of Adaptive Radiation by Dolph Schluter presented a testable framework that integrated ecology, genetics, and natural history to explain the mechanisms driving adaptive radiation, the rapid diversification of a single lineage into multiple species occupying distinct ecological niches. One important contribution was to re-orientate the study of adaptive r
The purpose of this study was to contribute to the development of a model including parameters for matching health-care services to patients. Inspired by ‘engaged scholarship’, the researchers practised continuous and close collaboration with practitioners at Region Skane in Sweden. The agenda was based on questions and experiences that evolved from theory and experience gained during previous res
Pedal acceleration time (PAT) has recently attracted clinical interest for assessing peripheral arterial disease (PAD), particularly in patients in whom ankle–brachial index (ABI) or toe pressure measurements are unreliable or not feasible, yet its diagnostic worth has not been systematically evaluated. We searched MEDLINE, Embase, ScienceDirect, and the Cochrane Library from inception to January
The European Court of Human Rights (ECtHR) has reiterated that states have discretion regarding what means to use to fulfil their positive obligations under the European Convention on Human Rights (ECHR). Given the “wide range of possible measures” that could be taken to ensure compliance with positive rights, these rights have a disjunctive structure since an omission has no definitive counterpar
Hairy cell leukemia (HCL) and HCL variant (HCLv) are distinct, rare, and chronic splenic B-cell lymphomas/leukemias that partially overlap in clinicopathologic presentation but differ in genetic basis, prognosis, and management. HCL is caused by the BRAF-V600E kinase–activating mutation in >95% of the patients, usually has excellent responses to chemotherapy with purine analogues, and is also amen
Animal manure from livestock production serves as a valuable organic fertilizer for agriculture as it provides nutrients, improves soil structure and increases the water retention capacity of the soil. However, animal manure is also the primary source of atmospheric ammonia emissions from Swedish agriculture, causing severe damage to the environment and health. To date, Sweden remains non-complian
