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In 2024–2025, the Cystic Fibrosis Foundation (US) and Cystic Fibrosis Trust (UK) hosted an International CFRD Consortium round-table webinar series for basic science, translational, and clinical researchers with the goal of sharpening mechanistic understanding of CFRD pathogenesis and prioritizing therapeutic development. This review summarizes the research priorities identified in the Internation
Snow flies ( Chionea ) are wingless crane flies uniquely adapted to extreme cold environments. Adults remain active throughout winter and move rapidly across the snow, even at temperatures below freezing. To investigate the molecular adaptations that make this possible, we sequenced and annotated the genome of Chionea alexandriana and compared it with related species and with the cold-adapted midg
Neurodegenerative diseases have traditionally been defined in vivo based on clinical symptoms. However, the development of biomarkers has enabled a shift towards in vivo biological definitions. There is now a need to characterize memory clinic populations using multi-dimensional biomarker information. Here, we employed a data-driven approach to develop a biological framework for categorizing indiv
The study of clines, or geographical variations of a given trait, can help understand how the interactions of genetics and local environments determine phenotypic diversity. The marine snail Littorina saxatilis (Olivi, 1792) exhibits a gradual change in the relative frequencies of shell color morphs across populations in the estuary system of the Rias Baixas (Galicia, NW Iberian Peninsula). A cons
The JPL rover Perseverance's investigations of Jezero crater's floor reveal that the ultramafic Séítah formation and the overlying mafic Máaz formation are deformed into a broad, low-amplitude structural dome. Mastcam-Z stereo images processed into digital outcrop models, together with RIMFAX ground-penetrating radar profiles, were used to reconstruct the three-dimensional stratal geometry of both
Background: Obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity; however, its relationship with subclinical coronary atherosclerosis detected incidentally on routine chest computed tomography (CT) remains incompletely defined. We aimed to evaluate the association between questionnaire-based OSA risk and moderate-to-severe coronary artery calcification (CAC) in patie
Corporate misconduct is a persistent feature of contemporary organizational life, yet corporations rarely acknowledge wrongdoing when confronted with allegations of harm. Instead, they rely on discursive strategies that protect legitimacy, organizational identity, and moral credibility. This chapter examines how corporations employ techniques of neutralization to defend themselves against accusati
Persistent circulating tumor DNA (ctDNA) during neoadjuvant treatment (NAT) of early breast cancer (EBC) indicates high-risk disease. Similarly, detection of ctDNA post-resection indicates molecular residual disease (MRD) and impending relapse. For ctDNA to be integrated into EBC management, accessible and scalable diagnostics are required. Here we apply an ultrasensitive, personalized tumor-infor
Minnesord över Eva Österbergs gärning som historiker, hennes forskningsinsatser och värdefulla arbete som handledare.
The David Jonas Festschrift is a collection of 67 contributions that cover the latest developments and applications in multidimensional and ultrafast spectroscopies, spanning a wide range of topics. The editorial provides background and summarizes the contributions to the special issue across the areas of experimental advances, theory and computation, proteins and biological systems, nanomaterials
Recent advances in the field of wild avian microbiome research have significantly deepened our understanding of the eco-evolutionary dynamics of bird–microbe interactions. Consequently, the field is now approaching a pivotal moment in uncovering the ultimate factors shaping avian microbiome structure, especially in relation to birds' ecological, evolutionary, and dietary diversity. Yet, avian micr
The digitalization of learning environments during the last decades has changed education at its core. At the same time as computers in the classroom offer multiple advantages, they also allow for multitasking and off-task behavior, undermining students’ attention and affecting their knowledge gains. In today’s highly digitalized classrooms, the challenge of maintaining student focus amidst pervasDue to an increase in unverified information that reaches people, data literacy, i.e. the understanding of how to interact with, and interpret information, becomes increasingly important for informed citizenship and responsible decision-making in a democratic society. Central to data literacy is the ability to draw conclusions based on existing data, as well as to interpret and evaluate numerical
A university student in China today might find himself or herself taking a “golden course” that blends practical and academic training. The student earns degree credit while gaining direct exposure to industry. The course might even be sponsored by Alibaba, the online retail giant, or another large firm.
We present a synthesis route for solid-state nanocatalysts composed of gallium phosphide nanowire supports decorated with catalytic palladium nanoparticles. Through precise control of fabrication conditions, we were able to tune the nanowire morphology, density, and crystal structure. The resulting catalysts were highly active and selective in the partial hydrogenation of phenylacetylene to styren
Bioenergy is the largest energy source in the Swedish energy system, where it consists mainly of domestic forest-based biomass in the form of residues and by-products. Today, there is a general discussion about the need for changes in national forest management policies and new European Union (EU) directives and regulations for forestry and bioenergy to better fulfil biodiversity and climate targe
